Evaluation of alkaline phosphatase isoenzymes in sera of hemodialysis and periton dialysis patients by agarose gel electrophoresis

Oktay, Gülgün; Fadiloğlu, Meral; Onvural, Banu; Çamsarı, Taner; Celik, Ali

doi:10.1042/bst023310s

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, one report has indicated that peritoneal dialysis per se may stimulate the intestine to secrete more intestinal ALP and intestinal variant ALP, leading to increased ALP activity in serum (3 ). I wish to report on two patients who were on long-term peritoneal dialysis and had moderately increased serum total ALP activity (2.4 and 4.4 kat/L, respectively; cutoff value Ͻ1.8 kat/L) without any biochemical signs of liver disease.…”

Section: Increased Serum Concentrations Of Intestinal Alkaline Phosphmentioning

confidence: 99%

Increased Serum Concentrations of Intestinal Alkaline Phosphatase in Peritoneal Dialysis

Zetterberg

2005

Clinical Chemistry

View full text Add to dashboard Cite

Section: Increased Serum Concentrations Of Intestinal Alkaline Phosphmentioning

confidence: 99%

Increased Serum Concentrations of Intestinal Alkaline Phosphatase in Peritoneal Dialysis

Zetterberg

2005

Clinical Chemistry

View full text Add to dashboard Cite

Serum Alkaline Phosphatase Predicts Mortality among Maintenance Hemodialysis Patients

Regidor

Kövesdy

Mehrotra³

et al. 2008

Journal of the American Society of Nephrology

219

222

View full text Add to dashboard Cite

Several observational studies have demonstrated that serum levels of minerals and parathyroid hormone (PTH) have U-or J-shaped associations with mortality in maintenance hemodialysis patients, but the relationship between serum alkaline phosphatase (AlkPhos) and risk for all-cause or cardiovascular death is unknown. In this study, a 3-yr cohort of 73,960 hemodialysis patients in DaVita outpatient dialysis were studied, and the hazard ratios for all-cause and cardiovascular death were higher across 20-U/L increments of AlkPhos, including within the various strata of intact PTH and serum aspartate aminotransferase. In the fully adjusted model, which accounted for demographics, comorbidity, surrogates of malnutrition and inflammation, minerals, PTH, and aspartate aminotransferase, AlkPhos Ն120 U/L was associated with a hazard ratio for death of 1.25 (95% confidence interval 1.21 to 1.29; P Ͻ 0.001). This association remained among diverse subgroups of hemodialysis patients, including those positive for hepatitis C antibody. A rise in AlkPhos by 10 U/L during the first 6 mo was incrementally associated with increased risk for death during the subsequent 2.5 yr. In summary, high levels of serum AlkPhos, especially Ͼ120 U/L, are associated with mortality among hemodialysis patients. Prospective controlled trials will be necessary to test whether serum AlkPhos measurements could be used to improve the management of renal osteodystrophy. 19: 219319: -220319: , 200819: . doi: 10.1681 In advanced chronic kidney disease (CKD; stages 3 through 5), secondary hyperparathyroidism (SHPT), along with renal osteodystrophy, is common and may be associated with abnormal mineral metabolism and/or abnormal serum or tissue mineral levels, vascular calcifications, and poor survival, espe- contributed to the study design and manuscript preparation and reviewed and approved the final manuscript. J Am Soc Nephrol

show abstract

Evaluation of alkaline phosphatase isoenzymes in sera of hemodialysis and periton dialysis patients by agarose gel electrophoresis

Cited by 2 publications

References 0 publications

Increased Serum Concentrations of Intestinal Alkaline Phosphatase in Peritoneal Dialysis

Increased Serum Concentrations of Intestinal Alkaline Phosphatase in Peritoneal Dialysis

Serum Alkaline Phosphatase Predicts Mortality among Maintenance Hemodialysis Patients

Contact Info

Product

Resources

About