Evaluation of alizarin and purpurin dyes for their ability to visualize latent fingermark on porous surfaces

Akar, Kıymet Berkil

doi:10.1016/j.scijus.2020.11.006

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…Preliminary/Pilot studies – New amino acid reagents were proposed to detect fingermarks on porous substrates: alizarin and purpurin [ 228 ]; 2-substituted-1,4-naphthoquinones and 2-substituted-1,4-anthraquinones [ 229 ]; fluorescent l -tyrosine derivatives [ 230 ]. The addition of liquid glue to a NIN solution (0.02–0.05 g/ml) was proposed to prevent the darkening of thermal papers while allowing NIN to react with fingermarks [ 231 ].…”

Section: Fingermark Visualisationmentioning

confidence: 99%

Interpol review of fingermarks and other body impressions (2019 – 2022)

Bécue

Champod

2023

Forensic Science International: Synergy

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Section: Fingermark Visualisationmentioning

confidence: 99%

Interpol review of fingermarks and other body impressions (2019 – 2022)

Bécue

Champod

2023

Forensic Science International: Synergy

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“…Alizarin (Figure 1a; 1,2-dihydroxyanthraquinone, Turkish red) is an anthraquinone reddish dye widely used for painting and textile dyeing (Berkil Akar, 2021). This compound is the main ingredient of madder lake pigments, such as rose madder and alizarin crimson (Wainwright, 2008).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the factors responsible for the low oral bioavailability of alizarin using a sensitive LC‐MS/MS method: In vitro, in situ, and in vivo evaluations

Seo

Han

Baek

et al. 2023

Drug Development Research

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Alizarin (1,2-dihydroxyanthraquinone) is an anthraquinone reddish dye widely used for painting and textile dyeing. As the biological activity of alizarin has recently attracted increasing attention from researchers, its therapeutic potential as complementary and alternative medicine is of interest. However, no systematic research has been conducted on the biopharmaceutical and pharmacokinetic aspects of alizarin. Therefore, this study aimed to comprehensively investigate the oral absorption and intestinal/hepatic metabolism of alizarin using a simple and sensitive tandem mass spectrometry method developed and validated in-house. The present method for the bioanalysis of alizarin has merits, including a simple pretreatment procedure, small sample volume, and adequate sensitivity. Alizarin exhibited pHdependent moderate lipophilicity and low solubility with limited intestinal luminal stability. Based on the in vivo pharmacokinetic data, the hepatic extraction ratio of alizarin was estimated to be 0.165-0.264, classified as a low level of hepatic extraction. In an in situ loop study, considerable fractions (28.2%-56.4%) of the alizarin dose were significantly absorbed in gut segments from the duodenum to ileum, suggesting that alizarin may be classified as the Biopharmaceutical Classification System class II. An in vitro metabolism study using rat and human hepatic S9 fractions revealed that glucuronidation and sulfation, but not NADPHmediated phase I reactions and methylation, are significantly involved in the hepatic metabolism of alizarin. Taken together, it can be estimated that the fractions of oral alizarin dose unabsorbed from the gut lumen and eliminated by the gut and liver before reaching the systemic circulation are 43.6%-76.7%, 0.474%-36.3%, and 3.77%-5.31% of the dose, respectively, resulting in a low oral bioavailability of 16.8%. Therefore, the oral bioavailability of alizarin depends primarily on its chemical degradation in the gut lumen and secondarily on first-pass metabolism.

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