Evaluation of agar films in prevention of postoperative peritoneal adhesions in animal model

Mamoudieh, Mohsen; Mirkheshti, Nooshin; Alavi, Sayyed Ali

doi:10.5505/tjtes.2011.15689

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…The alginate barrier had a higher efficacy compared with a commercialized barrier Interceed in an animal study 19 . Safety concerns for agar films were identified in an animal study, where there was an increased rate of adverse events 23 .…”

Section: Resultsmentioning

confidence: 99%

Barrier materials for prevention of surgical adhesions: systematic review

et al. 2022

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Background Postoperative surgical adhesions constitute a major health burden internationally. A wide range of materials have been evaluated, but despite constructive efforts and the obvious necessity, there remains no specific barrier widely utilized to prevent postoperative adhesion formation. The aim of this study was to highlight and characterize materials used for prevention of postoperative surgical adhesions in both animal and human studies. Methods A systematic review was performed of all original research articles presenting data related to the prevention of postoperative adhesions using a barrier agent. All available observational studies and randomized trials using animal models or human participants were included, with no restrictions related to type of surgery. PubMed and Embase databases were searched using key terms from inception to August 2019. Standardized data collection forms were used to extract details for each study and assess desirable characteristics of each barrier and success in animal and/or human studies. Results A total of 185 articles were identified for inclusion in the review, with a total of 67 unique adhesion barrier agents (37 natural and 30 synthetic materials). Desirable barrier characteristics of an ideal barrier were identified on review of the literature. Ten barriers achieved the primary outcome of reducing the incidence of postoperative adhesions in animal studies followed with positive outputs in human participants. A further 48 materials had successful results from animal studies, but with no human study performed to date. Discussion Multiple barriers showed promise in animal studies, with several progressing to success, and fulfilment of desirable qualities, in human trials. No barrier is currently utilized commonly worldwide, but potential barriers have been identified to reduce the burden of postoperative adhesions and associated sequelae.

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Section: Resultsmentioning

confidence: 99%

Barrier materials for prevention of surgical adhesions: systematic review

et al. 2022

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Drug delivery systems to prevent peritoneal metastasis after surgery of digestives or ovarian carcinoma: A review

Roy

Mignet

Pocard

et al. 2021

International Journal of Pharmaceutics

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Preliminary study with SprayShield ™ Adhesion Barrier System in the prevention of abdominal adhesions

Banasiewicz¹,

Horbacka²,

Karoń³

et al. 2013

wiitm

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IntroductionPeritoneal adhesions, the fibrotic bands that form between the surfaces in the peritoneal cavity following surgery, still pose a difficult clinical challenge.AimTo evaluate the SprayShield™ Adhesion Barrier System (PEG ester amine solution and a buffer solution) in reducing post-operative adhesion formation.Material and methodsThis was a prospective, multi-center, randomized, single blind study. A total of 11 subjects diagnosed with ulcerative colitis (UC) or familial adenomatous polyposis (FAP) were randomized: 8 to the SprayShield™ arm and 3 to the control arm. SprayShield™ was applied on the viscera directly under the midline peritoneal incision and at the site of ileostomy. During the follow-up surgery, the incidence, extent, and severity of post-operative adhesion formation were evaluated, as well as the time required to mobilize the ileal loop.ResultsIn patients who received SprayShield™ the time required to mobilize the ileal loop at the ileostomy closure was slightly shorter and the incidence and severity of adhesions were somewhat lower vs. control subjects (NS).ConclusionsSprayShield™ was found to be easy to use, safe, and quick to apply, and performed well in adherence and conformity. The incidence and severity of adhesions were lower for SprayShield™ subjects vs. control subjects, but due to the limited number of patients there are not enough data to confirm the effectiveness of the SprayShield™ Adhesion Barrier System in prevention of adhesions.

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Evaluation of agar films in prevention of postoperative peritoneal adhesions in animal model

Cited by 3 publications

References 19 publications

Barrier materials for prevention of surgical adhesions: systematic review

Barrier materials for prevention of surgical adhesions: systematic review

Drug delivery systems to prevent peritoneal metastasis after surgery of digestives or ovarian carcinoma: A review

Preliminary study with SprayShield ™ Adhesion Barrier System in the prevention of abdominal adhesions

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