Evaluation of adverse drug reactions reported to a poison control center between 2000 and 2007

Summary Aim: The aim of this systematic review was to critically evaluate the evidence regarding the adverse effects (AEs) of homeopathy. Method: Five electronic databases were searched to identify all relevant case reports and case series. Results: In total, 38 primary reports met our inclusion criteria. Of those, 30 pertained to direct AEs of homeopathic remedies; and eight were related to AEs caused by the substitution of conventional medicine with homeopathy. The total number of patients who experienced AEs of homeopathy amounted to 1159. Overall, AEs ranged from mild‐to‐severe and included four fatalities. The most common AEs were allergic reactions and intoxications. Rhus toxidendron was the most frequently implicated homeopathic remedy. Conclusion: Homeopathy has the potential to harm patients and consumers in both direct and indirect ways. Clinicians should be aware of its risks and advise their patients accordingly.

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“…e.g. (52); in this retrospective analysis of cases, homeopathy had the second highest hospitalisation index with a total of 255 AEs reported.…”

Section: Discussionmentioning

confidence: 74%

Adverse effects of homeopathy: a systematic review of published case reports and case series

Posadzki

Alotaibi

Ernst

2012

International Journal of Clinical Practice

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“…Based on previous studies, our study included 12 high-risk medication categories including: diabetic agents57101315, diuretics11131415, nonsteroidal anti-inflammatory drugs (NSAIDs)81011121319, anticoagulants5711121314151719, antiplatelets711121314, antihypertensives1113, antiarrhythmics1719, anticonvulsants9, antipsychotics891214, antidepressants912, benzodiazepine(BZD)/Z-hypnotics914, and narcotics571219, reimbursed by Taiwan’s NHI. In addition, subgroup analyses of the association between individual medication classes and unplanned hospitalization were performed for each category except anticoagulants and antiplatelets.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have adopted different approaches to identify ADE-related hospitalizations, such as analysis of spontaneous reporting data9, medical chart review5781011121314, and screening diagnostic codes from electronic medical databases151617. However, these methods are plagued with under-reporting issues and reporting bias.…”

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confidence: 99%

“…In addition, some of the methods are personnel-costly and time-consuming, resulting in studies with small sample sizes that cannot be generalized10121314. Furthermore, it is difficult to interpret the results between different medication categories in existing studies, since most studies only provide descriptive data on the frequency of ADE-related hospitalizations and do not consider the medication exposure prevalence within the population579111314151617.…”

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confidence: 99%

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Potentially high-risk medication categories and unplanned hospitalizations: a case–time–control study

Lin

Wen

Chen

et al. 2017

Sci Rep

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Empirical data of medication-related hospitalization are very limited. We aimed to investigate the associations between 12 high risk medication categories (diabetic agents, diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), anticoagulants, antiplatelets, antihypertensives, antiarrhythmics, anticonvulsants, antipsychotics, antidepressants, benzodiazepine (BZD)/Z-hypnotics, and narcotics) and unplanned hospitalizations. A population-based case-time-control study was performed using Taiwan Adverse drug events (ADEs) and their associated morbidity and mortality 1 represent a significant burden on the healthcare system 2 . Systemic reviews have estimated that approximately 5-10% of total hospital admissions are related to an ADE 3,4 . For the years 2004-2005 in the US, there were more than 700,000 ADE-related emergency department visits annually, and 1 of every 6 led to subsequent hospitalizations 5 . The annual cost of ADE in the US has been estimated at more than $ 136 billion 6 . In addition, the elderly are the most vulnerable to ADE-associated unplanned hospitalization 7 . For the elderly, the percentage of hospitalization attributed to ADE is estimated at 3.4-16.6% 8 . Since a great proportion of ADE-related hospitalizations are preventable 4 , efficient identification of ADE-related hospitalizations is therefore crucial to help highlight area which clinicians and policy-makers can put efforts in. Previous studies have adopted different approaches to identify ADE-related hospitalizations, such as analysis of spontaneous reporting data 9 , medical chart review 5,7,8,[10][11][12][13][14] , and screening diagnostic codes from electronic medical databases [15][16][17] . However, these methods are plagued with under-reporting issues and reporting bias. In addition, some of the methods are personnel-costly and time-consuming, resulting in studies with small sample sizes that cannot be generalized 10,[12][13][14] . Furthermore, it is difficult to interpret the results between different medication categories in existing studies, since most studies only provide descriptive data on

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“…Since the first poison control and drug information centers were established in the 1950s in North America and Europe, with measures of surveillance of poisoning incidents established on a national level, through population database implementation 3,25,26 . Similarly, the Jordan National Drug and Poison Information Center (JNDPIC) was established at the University of Jordan, Amman, Jordan in 2006, with the aim of providing a comprehensive collection of the most updated data and toxicology resources in the country 27 .…”

Section: Introductionmentioning

confidence: 99%

Retrospective assessment of acute poisoning incidents by nonpharmaceutical agents in Jordan: Data from Pharmacy One™ Poison Call Center, 2014 to 2018—Part I

Yehya

Albals

Issa

et al. 2020

Pharmacology Res & Perspec

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The Pharmacy One™ Poising Call Center (P 1 PCC), located in Amman, Jordan, was created to address deficiencies identified by the pharmacy service, including in the management of poisoning cases. The aims of this study were to analyze the patterns of poisoning cases reported to the P 1 PCC and to describe the role of the P 1 PCC pharmacist in ensuring preparedness and managing the response to poisoning cases. In addition, the information from these interventions was used to survey human poisoning in Jordan. This is a retrospective descriptive study of acute poisoning incidents in the Jordanian population, as recorded by the P 1 PCC during the period 2014-2018.Inquiries received by the P 1 PCC were recorded on a predesigned form. The year, patient demographics, toxic agent involved, and circumstances of the poisoning event were all fully documented utilizing Oracle and Excel spreadsheets. A total of 1992 poisoning incidents were reported to the P1PCC, predominately (68.59%) via 911 phone calls. Reports were predominantly from males (1.67:1). Children were the second most common age group after adolescents (22.62% and 42.49%, respectively). The most frequent causative nonpharmaceutical agents were household products (17%) in preschool children and animal bites (20%) in adolescents. Most of the poisoning incidents (74.63%) occurred at home. Unintentional poisoning (54.12%), with mild medical outcomes (61.45%), accounted for most of the poisoning incidents caused by exposure to household products. These data may represent the most recent picture of poisoning incidents in Jordan. Emergency medical services were provided by experienced pharmacy practitioners at the P 1 PCC, to respond to emergency needs in the community in a professional manner. Therefore, the need for unnecessary hospitalization and the cost of ambulance dispatch were minimized, which are highly valuable outcomes. K E Y W O R D SJordan, pharmacist, Pharmacy One™, poison control center

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Evaluation of adverse drug reactions reported to a poison control center between 2000 and 2007

Cited by 25 publications

References 37 publications

Adverse effects of homeopathy: a systematic review of published case reports and case series

Adverse effects of homeopathy: a systematic review of published case reports and case series

Potentially high-risk medication categories and unplanned hospitalizations: a case–time–control study

Retrospective assessment of acute poisoning incidents by nonpharmaceutical agents in Jordan: Data from Pharmacy One™ Poison Call Center, 2014 to 2018—Part I

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