Evaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome X

Güler, Ekrem; Güler, Gamze Babur; Kızılırmak, Filiz; Batgerel, Ulankhuu; Demir, Gültekin Günhan; Güneş, Hacı Murat; Karaca, Oğuz; Özcan, Özgür; Barutçu, İrfan; Türkmen, Muhsin; Esen, Ali Metin

doi:10.1007/s00059-014-4191-1

Cited by 10 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adiponectin levels were measured in 2 studies and were significantly lower in subjects with CMD compared with those without CMD. 68 , 69 Lipoprotein(a) levels were significantly higher is subjects with CMD compared with controls, and lipoprotein(a) was an independent predictor of CMD. 68 Last, in one small study, investigators found that circulating levels of adrenomedullin, a vasodilatory peptide that reduces oxidative stress, correlated with CFR and coronary flow–mediated dilation.…”

Section: Resultsmentioning

confidence: 92%

“… 68 , 69 Lipoprotein(a) levels were significantly higher is subjects with CMD compared with controls, and lipoprotein(a) was an independent predictor of CMD. 68 Last, in one small study, investigators found that circulating levels of adrenomedullin, a vasodilatory peptide that reduces oxidative stress, correlated with CFR and coronary flow–mediated dilation. 61 Among the biomarkers of endothelial function, data supporting endothelin‐1 appear the most convincing.…”

Section: Resultsmentioning

confidence: 92%

See 1 more Smart Citation

Circulating Biomarkers in Coronary Microvascular Dysfunction

Chakrala

Prakash

Valdes

et al. 2023

JAHA

View full text Add to dashboard Cite

Coronary microvascular dysfunction is an underdiagnosed pathologic process that is associated with adverse clinical outcomes. Biomarkers, molecules measurable in the blood, could inform the clinician by aiding in the diagnosis and management of coronary microvascular dysfunction. We present an updated review of circulating biomarkers in coronary microvascular dysfunction representing key pathologic processes, including inflammation, endothelial dysfunction, oxidative stress, coagulation, and other mechanisms.

show abstract

Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 92%

Circulating Biomarkers in Coronary Microvascular Dysfunction

Chakrala

Prakash

Valdes

et al. 2023

JAHA

View full text Add to dashboard Cite

show abstract

“…With the development of endothelial dysfunction, decrease in microvascular vasodilatation, increase in intracoronary pressure, and decrease in subendocardial perfusion occur, and the patient experiences angina pectoris ( 23 ). Moreover, decreased endogenous nitric oxide and adiponectin, increased plasma endothelin-1, and lipoprotein (a) were observed in CSX patients, and these are all thought to be indicators of endothelial dysfunction and premature atherosclerosis ( 24 , 25 ). We believe that the relationship between vitamin D deficiency and endothelial dysfunction is an explanation to our finding that vitamin D is associated with CSX and the abnormal response to exercise in patients with CSX.…”

Section: Discussionmentioning

confidence: 99%

Assessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome X

Güler

Hatipoğlu³

et al. 2016

Anatol J Cardiol

View full text Add to dashboard Cite

Objective:Vitamin D deficiency is associated with coronary artery disease, hypertension, heart failure, endothelial dysfunction, and metabolic syndrome. The pathophysiology of cardiac syndrome X (CSX) involves many pathways that are influenced by vitamin D levels. This study aimed to investigate the relationship between vitamin D deficiency and abnormal blood pressure response to exercise in patients with CSX.Methods:This was a cross-sectional and observational study. Fifty females with normal epicardial coronary arteries who presented with typical symptoms of rest or effort angina and 41 healthy age-matched female controls, were included. Patients with cardiomyopathy, severe valvular disease, congenital heart disease, and left ventricular hypertrophy were excluded. All patients underwent stress electrocardiography examination and 25-hydroxy (OH) vitamin D level measurements.Results:Levels of 25-OH vitamin D were significantly lower in CSX patients (9.8±7.3 ng/mL vs. 18.1±7.9 ng/mL; p<0.001). Systolic blood pressure (SBP) (188±15 mm Hg vs. 179±17 mm Hg; p=0.013) and diastolic blood pressure (DBP) (98±9 mm Hg vs. 88±9 mm Hg; p<0.001) during peak exercise were higher in CSX patients. Levels of 25-OH vitamin D were negatively correlated with peak SBP (r=–0.310, p=0.004) and peak DBP (r=–0.535, p<0.001) during exercise. To discard the multicollinearity problem, two different models were used for multivariate analyses. In the first model, metabolic equivalents (METs) (p=0.003) and 25-OH vitamin D levels (p=0.001) were independent predictors. METs (p=0.007), 25-OH vitamin D levels (p=0.008), and peak DBP were determined as independent predictors in the second multivariate model.Conclusion:In patients with CSX, 25-OH vitamin D levels were lower than those in controls; moreover, 25-OH vitamin D deficiency was also associated with higher levels of peak DBP during exercise. (Anatol J Cardiol 2016; 16: 961-6)

show abstract

“…Studies have shown that the content of lipoprotein an in patients with microvascular angina is significantly higher than that in normal people, while apolipoprotein a is significantly lower. Apolipoprotein a may be a protective factor [13][14][15][16] . Some studies have also confirmed that lipoprotein associated Phospholipase A2 (Lp PLA 2) can promote the release of inflammatory factors, reduce the production of nitric oxide, and lead to dysfunction of coronary microvascular endothelial cells.…”

Section: Risk Factorsmentioning

confidence: 99%

Rethinking on the pathogenesis, diagnosis and treatment of microvascular angina disease based on Chinese and foreign guidelines

2023

FMSR

View full text Add to dashboard Cite

Microvascular angina is a common non obstructive coronary artery ischemic heart disease in clinical practice. Its diagnosis is often empirical and can be mistaken for symptoms caused by non-cardiac factors, leading to delayed progression. With the development and upgrading of modern diagnostic and treatment technologies, the pathogenesis, diagnosis and treatment of MVA are receiving increasing attention from clinical physicians. More and more studies have confirmed that coronary microcirculation plays an important role in myocardial ischemia. This article summarizes the pathogenesis and diagnosis and treatment recommendations of microvascular angina in relevant Chinese and foreign guidelines, hoping to provide new diagnosis and treatment ideas for microvascular angina.

show abstract

Evaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome X

Abstract: We detected low adiponectin and high Lp(a) levels in patients with CSX and these findings may be related to the microvascular injury in CSX.

Cited by 10 publications

References 44 publications

Circulating Biomarkers in Coronary Microvascular Dysfunction

Circulating Biomarkers in Coronary Microvascular Dysfunction

Assessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome X

Rethinking on the pathogenesis, diagnosis and treatment of microvascular angina disease based on Chinese and foreign guidelines

Contact Info

Product

Resources

About