Evaluation of Adipokines Among Children Infected with Some Protozoan Intestinal Parasites

Abstract

Background: Adipokines are molecules produced by adipose tissue that have involvement in the body's energy/metabolic status and inflammation. It has recently been shown that there is a relationship between these molecules and infection with some intestinal parasites. Objectives: The current research aimed to assess the effect of Cryptosporidium and Giardia lamblia on adipokines. Patients and methods: This research was conducted in Baghdad from October 2021 to March 2022. The study included 56 children of both sexes, ranging in age from 2 to 15 years. The enrolled children were divided, according their stool examination, into infected by Giardia lamblia (n=21), infected by Cryptosporidium (n=23) and apparently healthy children (n=12). All participating children were subjected to some biometric measurements (body mass index (BMI), weight for age percentile and height for age percentile) and adipokines assessment (adiponectin, leptin and IL-6). Results: A significant increase (P˂0.05) in adiponectin and leptin were observed for Cryptosporidium and G. lamblia infections versus the control group. While significant decrease (P˂0.05) in IL-6 were noticed for Cryptosporidium and G. lamblia infections compared to the control group. BMI, weight for age percentile and height for age percentile were not significantly related with each of adiponectin, leptin and IL-6 for infected patients and control groups. Conclusions: Leptin and adiponectin secretion, as well as nutrient absorption, can be interfered with by intestinal Cryptosporidium and G. lamblia. Their precise function in intestinal parasitosis requires further study.

Serum and salivary adiponectin levels as predictive markers for diabetes mellitus in children with a family history of diabetes

“…This disagrees with other studies [35][36][37] that observed a significant negative correlation between plasma adiponectin levels and BMI. Additionally, our findings disagree with Lina et al [38], who noted a non-significant correlation between adiponectin and BMI.…”

Prevalence Study of the Intestinal Protozoal Parasitic Infections Rates at Babylon and Kerbala Cities

“…The results of the study showed that the highest infection rate with the Entamoeba histolytica parasite in Babylon hospitals was in the month of July, amounting to 25.5%, while the highest infection rate in Karbala city hospitals was in the month of May, amounting to 42.3% While the lowest percentage was in the months of December and November and reached ( 9.9% , 9.3% ) in hospitals in Babylon and Karbala, respectively. It agreed with the results of [23] study, and [24] as the percentage was highest in the month of July, and May, when it reached 31.1 % and 4.66% respectively he lowest infection rate was with the [24] study, which was in December and reached 3.87%…”

Alteration of Serum Lipid Profiles among Amoebasis and Giardiasis Confirmed Patients at North West Ethiopia

“…A diseases formation of these parasite is related with effect of trophozoite attachment to upper portion of small intestine, and their protolytic enzymes (cysteine proteases and glycosidases) (10,11). This increases rate of enterocyte apoptosis, loss of barrier function, leading to lymphocyte-mediated microvillus shortening and reduction of absorptive surface area, ultimately are responsible for mal-digestion and malabsorption of nutrients (12)(13)(14). In acute clinical stages, are almost clinically overlapping that characterized by fever, watery diarrhea and other intestinal disorders (6,15).…”