Evaluation of additive effect of quantitative fetal fibronectin to cervical length for prediction of spontaneous preterm birth among asymptomatic low‐risk women

Jwala, Sushma; Tran, Tino L.; Terenna, Courtney; McGregor, Ali; Andrel, Jocelyn; Leiby, Benjamin E.; Baxter, Jason K.; Berghella, Vincenzo

doi:10.1111/aogs.12907

Cited by 23 publications

(21 citation statements)

References 24 publications

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“…A study by Jwala et al. in 2016 suggested that quantitative fFN and and cervical length measurement in asymptomatic women without risk factors for PTB increase the sensitivity of fFN, but whether this is useful clinically has not been determined. A recent prospective study comparing women with a previous history of PTB with women without a history of PTB found that a positive fFN was the best predictor for recurrence of PTB, increasing the recurrence risk between two‐ to fourfold that in women without a positive fFN result .…”

Section: Discussionmentioning

confidence: 99%

Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta‐analysis

Santos

Daru

Rogozińska

et al. 2018

Acta Obstet Gynecol Scand

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Section: Discussionmentioning

confidence: 99%

Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta‐analysis

Santos

Daru

Rogozińska

et al. 2018

Acta Obstet Gynecol Scand

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“…6 There is no consensus among authors regarding the value of cervical length that is considered short and the associated risk for premature labor, the reported values varying between 20 and 25 mm. [7][8][9] The importance of cervical biometry in screening patients for preterm labor has been highlighted in several publications; however, studies that have investigated the techniques of cervical measurement are rare. The evaluation of uterine cervical morphology is important because it is technically more difficult to measure cervical length in cases of curved uterine cervices, and the best measuring method in these cases is still controversial.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Length of Maternal Cervix between 18 and 24 weeks of Gestation in a Low-Risk Brazilian Population

Andrade

Júnior

et al. 2017

Rev Bras Ginecol Obstet

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Purpose To determine cervical biometry in pregnant women between 18 and 24 weeks of gestation and the ideal mode of measurement of cervical length in cases of curved and straight cervical morphology. Methods The uterine cervices of 752 low-risk pregnant women were assessed using transvaginal ultrasound in a prospective cross-sectional study. In women with straight uterine cervices, cervical biometry was performed in a continuous manner. In women with curved uterine cervices, the biometry was performed using both the continuous and segmented techniques (in segments joining the cervical os). Polynomial regression models were created to assess the correlation between the cervical length and gestational age. The paired Student t-test was used to compare measuring techniques. Results The cervical biometry results did not vary significantly with the gestational age and were best represented by linear regression (R 2 ¼ 0.0075 with the continuous technique, and R 2 ¼ 0.0017 with the segmented technique). Up to the 21 st week of gestation, there was a predominance of curved uterine cervix morphology (58.9%), whereas the straight morphology predominated after this gestational age (54.2%). There was a significant difference between the continuous and the segmented measuring methods in all the assessed gestational ages (p < 0.001). Conclusion Cervical biometry in pregnant women between 18 and 24 weeks was represented by a linear regression, independently of the measuring mode. The ideal measuring technique was the transvaginal ultrasound performed at a gestational age !21 weeks.

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“…To date, there is little evidence to support the adoption of such screening into routine clinical practice in low-risk pregnant women (150). It may have greater utility in the screening of women with other established risk factors (151–153).…”

Section: “Omics” and Precision Public Healthmentioning

confidence: 99%

Applying Precision Public Health to Prevent Preterm Birth

Newnham

Kemp

White

et al. 2017

Front. Public Health

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Preterm birth (PTB) is one of the major health-care challenges of our time. Being born too early is associated with major risks to the child with potential for serious consequences in terms of life-long disability and health-care costs. Discovering how to prevent PTB needs to be one of our greatest priorities. Recent advances have provided hope that a percentage of cases known to be related to risk factors may be amenable to prevention; but the majority of cases remain of unknown cause, and there is little chance of prevention. Applying the principle of precision public health may offer opportunities previously unavailable. Presented in this article are ideas that may improve our abilities in the fields of studying the effects of migration and of populations in transition, public health programs, tobacco control, routine measurement of length of the cervix in mid-pregnancy by ultrasound imaging, prevention of non-medically indicated late PTB, identification of pregnant women for whom treatment of vaginal infection may be of benefit, and screening by genetics and other “omics.” Opening new research in these fields, and viewing these clinical problems through a prism of precision public health, may produce benefits that will affect the lives of large numbers of people.

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Evaluation of additive effect of quantitative fetal fibronectin to cervical length for prediction of spontaneous preterm birth among asymptomatic low‐risk women

Cited by 23 publications

References 24 publications

Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta‐analysis

Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta‐analysis

Assessment of Length of Maternal Cervix between 18 and 24 weeks of Gestation in a Low-Risk Brazilian Population

Applying Precision Public Health to Prevent Preterm Birth

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