Evaluation of Acute Physiology and Chronic Health Evaluation III predictions of hospital mortality in an independent database

Zimmerman, Jack E.; Wagner, Douglas P.; Draper, Elizabeth A.; Wright, Leslie; Alzola, Carlos; Knaus, William A.

doi:10.1097/00003246-199808000-00012

Cited by 240 publications

(137 citation statements)

References 55 publications

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“…Mortality outside the ICU was regrettably much higher, up to 53% (28). This has been confirmed by other reports (29)(30)(31)(32)(33)(34)(35), and it strongly suggests that all patients with severe sepsis and septic shock should be admitted to the ICU.…”

Section: Discussionsupporting

confidence: 69%

Epidemiología de la sepsis en unidades de cuidado intensivo en Colombia

Ortíz¹,

Dueñas²,

Rodríguez

et al. 2013

biomedica

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Section: Discussionsupporting

confidence: 69%

Epidemiología de la sepsis en unidades de cuidado intensivo en Colombia

Ortíz¹,

Dueñas²,

Rodríguez

et al. 2013

biomedica

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“…The APACHE(Acute Physiology, Age, Chronic Health Evaluation) scoring system, a prototype of a classification system for disease severity, has continued to evolve into newer versions over the last twenty years through validations of discrimination and calibration regarding prognosis (4)(5)(6). The APACHE III scoring system as a methodology of risk prediction of hospital mortality (6) is currently used in many studies worldwide (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Current Practice of Management of Bacteremic Sepsis: A Study in a Tertiary Care Teaching Hospital in Japan.

et al. 2000

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Objective To investigate how patients with bacteremic sepsis are managedin a tertiary care teaching hospital. Patients and Methods Prospective observational study on patients with bacteremic sepsis. Clinical and microbiological characteristics of bacteremicsepsis were analyzed in relation to prognosis. Severity of the illness was quantitatively analyzed by the APACHE(Acute Physiology, Age, Chronic Health Evaluation) III scoring system. Also investigated was how closely physicians paid attention to acute physiological alterations in patients. Results The 28-day mortalities in fifty hemodynamically stable patients and in twenty-three septic shock patients were 26% and 52%, respectively (p=0.028). Grampositive organisms accounted for 54 %of all organisms, with the mortality and incidence of septic shock being the same as with Gram-negative infections. The mean APACHE III score was 42.9 in survivors, and 76.5 in non-survivors (p < 0.001). Although serum levels of C-reactive protein and acute physiology score (APS) was significantly higher in non-survivors than in survivors, the correlation with APACHE III score was more prominent in APS. The number of vital signs recorded was 1.67 in physicians and 3.6 in nurses (p < 0.001). Conclusions The present study proved that the APACHE III score accurately discriminates between survivors and non-survivors of patients with sepsis. By addressing the need for an objective evaluation of severity of illness, it strongly recommendsthat physicians should be madeaware of physiologically defined sepsis and that they should pay closer attention to patients' physiological alterations to identify the development of sepsis in critically ill patients. (Internal Medicine 39: 901-909, 2000)

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“…Zimmerman ve ark. 'nın (4) yaptıkları çalışmada toplam 285 hastanenin verileri incelenmiş olup yoğun bakım mortalitesi %12 olarak saptamışken, bir diğer çalışmada ise bu oran %26,7 olarak bulunmuştur (4,5 Bilindiği üzere serum albümini beslenmenin en önemli göstergelerinden biri olması yanında kronik sistemik bir hastalığın varlığında da düzeyi azalan negatif bir akut faz göstergesidir. Dolayısı ile albümin düzeyi düşük hastalarda mortalitenin yüksek bulunması beklenir ki bizim çalışmamızda da regresyon analizinde bu gösterilmiştir (Tablo 3).…”

Section: Discussionunclassified

Effect of Baseline Datas on the Survival of Intensive Care Unit Patients

Akkoç¹,

Alpay²,

Toptaş³

et al. 2017

Haseki

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AnahtarSözcükler: Mortalite, sağkalım, yoğun bakım ünitesi Aim: We investigated demographic features and systemic diseases which affect mortality and the importance of the biochemical analyzes on admission in patients admitted to intensive care unit (ICU). Methods:We included 1748 patients (55% male) who were admitted to the ICU at our hospital between 2012 and 2014. The mean age of the patients was 61.8±19.2 years. Data on age, gender, presence of systemic diseases and surgery, duration of hospitalization and biochemical parameters on admission were analyzed. Results:The mean length of hospitalization was 18.4±34.3 (median=6) days. 32.1% of patients were postoperative patients. 45.7% of patients died. The rate of presence of multiple diseases, nervous system, cerebrovascular, and cardiovascular diseases and laboratory parameters including urea, creatinine, lactate dehydrogenase (LDH), and leucocytes were significantly higher and the mean albumin level was lower in patients who died compared to those in patients who were discharged from the hospital. Age, creatinine, albumin and LDH values were found to be significantly important factors by multivariate analysis conducted to examine predictors of mortality while gender, presence of multiple diseases, diagnostic code and being postoperative or not were found to have no significant importance. Conclusion:Baseline evaluation of pathologies that may play a role in mortality of ICU patients may be important for survival prediction. Evaluation of these factors on admission may contribute to development of different approaches to high-risk patients.

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Evaluation of Acute Physiology and Chronic Health Evaluation III predictions of hospital mortality in an independent database

Cited by 240 publications

References 55 publications

Epidemiología de la sepsis en unidades de cuidado intensivo en Colombia

Epidemiología de la sepsis en unidades de cuidado intensivo en Colombia

Current Practice of Management of Bacteremic Sepsis: A Study in a Tertiary Care Teaching Hospital in Japan.

Effect of Baseline Datas on the Survival of Intensive Care Unit Patients

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