Evaluation of Acute Oral Toxicity, Brine Shrimp Lethality, and Antilymphoma Activity of Geranylgeraniol and Annona macroprophyllata Leaf Extracts

Calzada, Fernando; Ramírez-Santos, Jesica; Valdés, Miguel Ángel Serra; García-Hernández, Normand; Pina-Jiménez, Emmanuel; Ordóñez-Razo, Rosa María

doi:10.1007/s43450-020-00014-8

Cited by 9 publications

(19 citation statements)

References 5 publications

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“…The WHO estimated that the number will increase to 9.9% of the population (629 million people) by 2045 [2,3]. The chronic hyperglycemia of diabetes is associated with Annona diversifolia Safford is a common tree indigenous in Mexico known by many local names such as "Ilama", "Ilama Zapote", "Ilamazapotl", "Izlama", "Hilama", "Papauce", "Papausa", "Anona blanca", and "Zapote de vieja" [36][37][38][39][40][41]. The fruit of this plant is used as food; its leaves are employed as anticonvulsant, analgesic, anti-inflammatory, and antidiabetic agents in Mexican traditional medicine [37][38][39].…”

Section: Introductionmentioning

confidence: 99%

“…The fruit of this plant is used as food; its leaves are employed as anticonvulsant, analgesic, anti-inflammatory, and antidiabetic agents in Mexican traditional medicine [37][38][39]. Several pharmacological studies reported its anxiolytic [37], antilymphoma [38], antinociceptive [39], anticonvulsant [40,41], antimicrobial [42], antiproliferative [43], antiepileptic [44], anxiolytic [45], and antihyperglycemic effects [36,46]. The ethanolic extract from the leaves of A. diversifolia and farnesol, an acyclic sesquiterpene isolated from this plant, showed antihyperglycemic activity in female mice [36].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Annona diversifolia Safford is a common tree indigenous in Mexico known by many local names such as “Ilama”, “Ilama Zapote”, “Ilamazapotl”, “Izlama”, “Hilama”, “Papauce”, “Papausa”, “Anona blanca”, and “Zapote de vieja” [ 36 , 37 , 38 , 39 , 40 , 41 ]. The fruit of this plant is used as food; its leaves are employed as anticonvulsant, analgesic, anti-inflammatory, and antidiabetic agents in Mexican traditional medicine [ 37 , 38 , 39 ]. Several pharmacological studies reported its anxiolytic [ 37 ], antilymphoma [ 38 ], antinociceptive [ 39 ], anticonvulsant [ 40 , 41 ], antimicrobial [ 42 ], antiproliferative [ 43 ], antiepileptic [ 44 ], anxiolytic [ 45 ], and antihyperglycemic effects [ 36 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

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Antihyperglycemic Effects of Annona diversifolia Safford and Its Acyclic Terpenoids: α-Glucosidase and Selective SGLT1 Inhibitiors

et al. 2020

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Annona diversifolia Safford and two acyclic terpenoids were evaluated to determine their antihyperglycemic activity as potential α-glucosidase and selective SGLT-1 inhibitiors. Ethanolic extract (EEAd), chloroformic (CHCl3Fr), ethyl acetate (EtOAcFr), aqueous residual (AcRFr), secondary 5 (Fr5) fractions, farnesal (1), and farnesol (2) were evaluated on normoglycemic and streptozocin-induced diabetic mice. EEAd, CHCl3Fr, Fr5, (1) and (2) showed antihyperglycemic activity. The potential as α-glucosidase inhibitors of products was evaluated with oral sucrose and lactose tolerance (OSTT and OLTT, respectively) and intestinal sucrose hydrolysis (ISH) tests; the potential as SGLT-1 inhibitors was evaluated using oral glucose tolerance (OGTT), intestinal glucose absorption (IGA), and urinary glucose excretion (UGE) tests. In OSTT and OLTT, all treatments showed significant activity at two and four hours. In ISH, half maximal effective concentrations (CE50) of 565, 662 and 590 μg/mL, 682 and 802 μM were calculated, respectively. In OGTT, all treatments showed significant activity at two hours. In IGA, CE50 values of 1059, 783 and 539 μg/mL, 1211 and 327 μM were calculated, respectively. In UGE Fr5, (1) and (2) showed significant reduction of the glucose excreted compared with canagliflozin. These results suggest that the antihyperglycemic activity is mediated by α-glucosidase and selective SGLT-1 inhibition.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antihyperglycemic Effects of Annona diversifolia Safford and Its Acyclic Terpenoids: α-Glucosidase and Selective SGLT1 Inhibitiors

et al. 2020

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“…In 2015, nearly 4.3 million people around the world were reported with NHL, which accounted for 231,400 deaths. In Mexico until 2017, NHL were the fourth cause of mortality between patients with cancer [ 1 ]. The anticancer drugs commonly used alone or combined for the treatment of NHL include cyclophosphamide, prednisone, cisplatin, methotrexate, and doxorubicin as well as vincristine and etoposide.…”

Section: Introductionmentioning

confidence: 99%

Incomptine A Induces Apoptosis, ROS Production and a Differential Protein Expression on Non-Hodgkin’s Lymphoma Cells

Pina-Jiménez

Calzada

Bautista

et al. 2021

IJMS

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Sesquiterpene lactones are of pharmaceutical interest due their cytotoxic and antitumor properties, which are commonly found within plants of several genera from the Asteraceae family such as the Decachaeta genus. From Decachaeta incompta four heliangolide, namely incomptines A-D have been isolated. In this study, cytotoxic properties of incomptine A (IA) were evaluated on four lymphoma cancer cell lines: U-937, Farage, SU-DHL-2, and REC-1. The type of cell death induced by IA and its effects on U-937 cells were analyzed based on its capability to induce apoptosis and produce reactive oxygen species (ROS) through flow cytometry with 4′,6-diamidino-2-phenylindole staining, dual annexin V/DAPI staining, and dichlorofluorescein 2′,7′-diacetate, respectively. A differential protein expression analysis study was carried out by isobaric tags for relative and absolute quantitation (iTRAQ) through UPLC-MS/MS. Results reveal that IA exhibited cytotoxic activity against the cell line U-937 (CC50 of 0.12 ± 0.02 μM) and the incubation of these cells in presence of IA significantly increased apoptotic population and intracellular ROS levels. In the proteomic approach 1548 proteins were differentially expressed, out of which 587 exhibited a fold-change ≥ 1.5 and 961 a fold-change ≤ 0.67. Most of these differentially regulated proteins are involved in apoptosis, oxidative stress, glycolytic metabolism, or cytoskeleton structuration.

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Anti‐Phytopathogenic and Phytotoxic Effects of Annona glabra Lin. and Annona muricata Lin. Seed Extracts: In vitro and In vivo Assessment, Bioactive Compound Quantification, and Mechanism Involved

Le Dang,

Quoc Nguyen,

De Tran

et al. 2024

ChemistrySelect

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Building upon prior research demonstrating the excellent antifungal and nematicidal efficacy of Annona squamosa Lin. seed extracts, this study extends its scope to investigate similar properties in seed extracts from two other Annonaceae species: Annona muricata Lin. and Annona glabra Lin. The focus is on assessing their effectiveness against tomato late blight (TLB) and wheat leaf rust (WLR) diseases, as well as their broader antifungal activity against Colletotrichum sp. and Fusarium sp. The A. glabra seed extract exerted a superior control efficacy against TLB (85 % at 62.5 μg/mL) and WLR (75 % at 125 μg/mL) in vivo. The two Annonaceous extracts also exhibited in vitro antifungal inhibition against Colletotrichum sp. and Fusarium sp., as well as toxicology against pine wilt nematodes and Artemia salina. Besides, they showed phytotoxicity against Raphanus sativus seed germination. Squamocin G, a potent bioactive acetogenin, was isolated from A. glabara, which was found to occur at high contents in the following ascending order in A. glabra, A. muricata and A. squamosa dichloromethane extracts. To investigate the antifungal mechanism, molecular docking and molecular dynamic of squamocin G ligand were also performed for the first time at the active site of succinate dehydrogenase and β‐tubulin.

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Evaluation of Acute Oral Toxicity, Brine Shrimp Lethality, and Antilymphoma Activity of Geranylgeraniol and Annona macroprophyllata Leaf Extracts

Cited by 9 publications

References 5 publications

Antihyperglycemic Effects of Annona diversifolia Safford and Its Acyclic Terpenoids: α-Glucosidase and Selective SGLT1 Inhibitiors

Antihyperglycemic Effects of Annona diversifolia Safford and Its Acyclic Terpenoids: α-Glucosidase and Selective SGLT1 Inhibitiors

Incomptine A Induces Apoptosis, ROS Production and a Differential Protein Expression on Non-Hodgkin’s Lymphoma Cells

Anti‐Phytopathogenic and Phytotoxic Effects of Annona glabra Lin. and Annona muricata Lin. Seed Extracts: In vitro and In vivo Assessment, Bioactive Compound Quantification, and Mechanism Involved

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