Evaluation of acute kidney injury in dogs with complicated or uncomplicated Babesia rossi infection

Defauw, Pieter; Schoeman, Johan P.; Leisewitz, Andrew L.; Goddard, Amelia; Duchateau, Luc; Aresu, Luca; Meyer, Evelyne; Daminet, Sylvie

doi:10.1016/j.ttbdis.2020.101406

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…However, further study on a larger group of infected dogs is needed. Moreover, determination of other indices of kidney injury, such as kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin, which were detected in canine babesiosis, could allow for the determination of the de Ritis quotient, which indicates renal injury in azotaemic dogs [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Increased the De Ritis Quotient and Renal Azotaemia in Canine Babesiosis

Gójska-Zygner¹,

Karabowicz

Bartosik

et al. 2022

Animals

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Previous studies of azotaemia in canine babesiosis revealed pre-renal and renal azotaemia in infected dogs, and an association between an increased de Ritis quotient (aspartate aminotransferase to alanine aminotransferase activity; AST/ALT ratio) and azotaemia in affected animals. Serum activities of AST and ALT, and AST/ALT ratio were compared between azotaemic and non-azotaemic dogs infected with Babesia canis, and between affected dogs with pre-renal and renal azotaemia. Statistical analyses revealed higher AST activity and an increased AST/ALT ratio in azotaemic dogs, and an increase of these two parameters in infected dogs with renal azotaemia in comparison to dogs with pre-renal azotaemia. Moreover, AST activity and AST/ALT ratio were correlated with renal indices such as renal failure index, sodium fractional excretion, and urinary creatinine to serum creatinine ratio. The study also revealed a lack of correlation between AST and ALT activities in azotaemic dogs, although a correlation was observed when including all dogs in this study (azotaemic and non-azotaemic dogs treated as one group). The results of this study indicate that increased serum AST activity in azotaemic dogs infected with B. canis may have a renal origin, and the AST/ALT ratio could be considered as a simple and convenient renal index that is useful in the recognition of renal azotaemia in canine babesiosis.

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Section: Discussionmentioning

confidence: 99%