Evaluation of acrylic bone cements with single and combined antibiotics: Release behavior and<i>in vitro</i>antibacterial effectiveness

Alonso, Lizette Morejón; Ruiz, Adriana Patricia Mendizábal; Flores, J.; Herrera, Dalia Lorena Rodríguez; García, Ofelia Rodríguez; Lozano, O.; García-Menocal, José Ángel Delgado; Estévez, Gastón Fuentes

doi:10.1080/00914037.2017.1383250

Cited by 4 publications

(1 citation statement)

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“…Some studies have also shown how the release of cement also depends on the type of cement used [48]. To achieve a broader spectrum of action and efficacy it is possible to combine two or more antibiotics, exploiting their synergistic effect [47,49,50]. Comparison between spacers loaded with the combination of gentamicin and vancomycin and spacers loaded with gentamicin alone has shown the higher antibacterial efficacy of the former.…”

Section: Cement With Antibacterial Activity: Antibiotic-loaded Bonmentioning

confidence: 99%

PMMA-Based Bone Cements and the Problem of Joint Arthroplasty Infections: Status and New Perspectives

et al. 2019

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Polymethyl methacrylate (PMMA)-based bone cement is a biomaterial that has been used over the last 50 years to stabilize hip and knee implants or as a bone filler. Although PMMA-based bone cement is widely used and allows a fast-primary fixation to the bone, it does not guarantee a mechanically and biologically stable interface with bone, and most of all it is prone to bacteria adhesion and infection development. In the 1970s, antibiotic-loaded bone cements were introduced to reduce the infection rate in arthroplasty; however, the efficiency of antibiotic-containing bone cement is still a debated issue. For these reasons, in recent years, the scientific community has investigated new approaches to impart antibacterial properties to PMMA bone cement. The aim of this review is to summarize the current status regarding antibiotic-loaded PMMA-based bone cements, fill the gap regarding the lack of data on antibacterial bone cement, and explore the progress of antibacterial bone cement formulations, focusing attention on the new perspectives. In particular, this review highlights the innovative study of composite bone cements containing inorganic antibacterial and bioactive phases, which are a fascinating alternative that can impart both osteointegration and antibacterial properties to PMMA-based bone cement.

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