Evaluation of acquired color vision deficiency in retinal vein occlusion using the Rabin cone contrast test

Matsumoto, Riko; Saishin, Yoshitsugu; Ohji, Masahito

doi:10.1007/s00417-021-05171-7

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Regarding ERM, our data demonstrated statistically significant worsened CCT scores across S, M, and L cones compared to healthy controls, however there was no statistically significant differences in scores across worsening ERM grades. Finally, we found worsened S, M, and L cone CCT scores in eyes affected by RVO compared to unaffected fellow eyes, which agrees with published studies [ 44 ].…”

Section: Discussionsupporting

confidence: 93%

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Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases

et al. 2023

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Background Cone contrast threshold testing (CCT) provides quantitative measurements of color and contrast function to reveal changes in vision quality that are not standard endpoints in clinical trials. We utilize CCT to measure visual function in patients with multiple sclerosis (MS), age-related macular degeneration (AMD), epiretinal membrane (ERM), and retinal vein occlusion (RVO). Methods Retrospective data was gathered from 237 patients of the Gavin Herbert Eye Institute. Subjects included 17 patients with MS, 45 patients with AMD, 41 patients with ERM, 11 patients with RVO, and 123 healthy controls. Patients underwent the primary measurement outcome, CCT testing, as well as Sloan visual acuity test and spectral domain optical coherence tomography during normal care. Results Color and contrast deficits were present in MS patients regardless of history of optic neuritis. AMD with intermediate or worse disease demonstrated reduced CCT scores. All 3 stages of ERM demonstrated cone contrast deficits. Despite restoration of visual acuity, RVO-affected eyes demonstrated poorer CCT performance than unaffected fellow eyes. Conclusions CCT demonstrates color and contrast deficits for multiple retinal diseases with differing pathophysiology. Further prospective studies of CCT in other disease states and with larger samples sizes is warranted.

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Section: Discussionsupporting

confidence: 93%

“…al. [ 44 ], who demonstrated similar findings in statistically significant loss of all S, M, and L cones testing in eyes affected by RVO when compared to the healthy eye.…”

Section: Discussionmentioning

confidence: 62%

Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases

et al. 2023

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“… 29 , 30 Other computerized color vision tests are also available, such as the CAD test from the City University London which has been extensively used and is approved for testing 19 , 31 of aviation pilots and other tests as ColorDx CCT HD 32 and Rabin cone contrast test. 33 …”

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confidence: 99%

The Association Between Acquired Color Deficiency and PET Imaging of Neurodegeneration in Mild Cognitive Impairment and Alzheimer Disease

Vidal

Decleva

Barboni

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose To evaluate color vision changes and retinal processing of chromatic and luminance pathways in subjects with Alzheimer disease (AD) and mild cognitive impairment (MCI) compared with a matched control group and whether such changes are associated with impaired brain glucose metabolism and β-amyloid deposition in the brain. Methods We evaluated 13 patients with AD (72.4 ± 7.7 years), 23 patients with MCI (72.5 ± 5.5 years), and 18 controls of comparable age ( P = 0.44) using Cambridge color test and the heterochromatic flicker ERG (HF-ERG). The Cambridge color test was performed using the trivector protocol to estimate the protan, deutan and tritan color confusion axes. HF-ERG responses were measured at a frequency of 12 Hz, which ERGs reflect chromatic activity, and at 36 Hz, reflecting luminance pathway. A study subsample was performed using neuropsychological assessments and positron emission tomography. Results Patients with AD presented higher mean values indicating poorer color discrimination for protan ( P = 0.04) and deutan ( P = 0.001) axes compared with the controls. Along the tritan axis, both patients with AD and patients with MCI showed decreased color vision ( P = 0.001 and P = 0.001) compared with controls. The analyses from the HF-ERG protocol revealed no differences between the groups ( P = 0.31 and P = 0.41). Diffuse color vision loss was found in individuals with signs of neurodegeneration (protan P = 0.002, deutan P = 0.003 and tritan P = 0.01), but not in individuals with signs of β-amyloid deposition only (protan P = 0.39, deutan P = 0.48, tritan P = 0.63), regardless of their clinical classification. Conclusions Here, patients with AD and patients with MCI present acquired color vision deficiency that may be linked with impaired brain metabolism.

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Cone-isolation contrast sensitivity – do pupil and stimulus sizes matter?

Cisarik,

Kampwerth

2023

Clinical and Experimental Optometry

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Evaluation of acquired color vision deficiency in retinal vein occlusion using the Rabin cone contrast test

Cited by 5 publications

References 19 publications

Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases

Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases

The Association Between Acquired Color Deficiency and PET Imaging of Neurodegeneration in Mild Cognitive Impairment and Alzheimer Disease

Cone-isolation contrast sensitivity – do pupil and stimulus sizes matter?

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