Evaluation of acetone cyanohydrin effect in "in vitro" inativation of the Ehrlich ascites tumor cells

Ramalho, Rondon Tosta; Aydos, Ricardo Dutra; Cereda, Marney Pascoli

doi:10.1590/s0102-86502010000100022

Cited by 8 publications

(5 citation statements)

References 11 publications

(6 reference statements)

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“…by the seventh day after inoculation and showed varying shapes and The action of cyanogenic chemotherapy using AC as cyanide source in the experiment developed suggests the ability of tumor cells to irreversibly poison the action of cyanide, thereby providing a dose-and time-dependent effect 12, , as occurred in previous studies 8,9 . Cyanide toxicity occurs in two ways: ATP depletion caused by blockage of oxidative phosphorylation and production of reactive oxygen species 12 .…”

Section: All Inoculated Animals Developed Solid Ehrlich Tumor (Set)mentioning

confidence: 54%

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Histopathological evaluation of tumor necrosis and volume after cyanogenic chemotherapy

Ramalho

Aydos²,

Schettert³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To determine the percentage of tumoral necrosis and volume after cyanogenic chemotherapy. METHODS:Histopathological findings of 20 Swiss mice inoculated subcutaneously in the left abdominal wall with 0.05 ml of cell suspension containing 2.5 x 10 5 viable cells of the Ehrlich tumor were evaluated. The tumor response to cyanogenic chemotherapy was determined using a system that comprises two inhibition factors of tumor growth by calculating the percentage of necrosis in the tumor tissue and calculation of tumor volume in treated animals relative to that in control animals. The importance of this system has been validated by the correlation between tumor inhibition in the groups treated with the respective percentages of necrosis. RESULTS:While the control group presented an average of 13.48 ± 14.71% necrosis and average tumor volume of 16.18 ± 10.94, the treated group had an average of 42.02 ± 11.58 and 6.8 ± 3.57, respectively. The tumor inhibition was significantly associated with treatment (p=0.0189). The analysis of necrosis percentage showed a significant prognostic importance (p=0.0001). CONCLUSION:It is concluded that the effect of cyanogenic chemotherapy showed strong inhibitory action of tumor growth, as well as an increase in its area of necrosis.

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Section: All Inoculated Animals Developed Solid Ehrlich Tumor (Set)mentioning

confidence: 54%

“…This quite possibly occurs by a defect in the detoxification process of cyanide in tumor cells involving cell stocks of sulfur, in which they are easily intoxicated even with low doses of cyanide 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Histopathological evaluation of tumor necrosis and volume after cyanogenic chemotherapy

Ramalho

Aydos²,

Schettert³

et al. 2014

Acta Cir. Bras.

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“…The residual cyanide aspect has been addressed in recent research and these investigations have shown that this component has relevant biological activity when in low concentrations. [40] show that cyanide is a compound that is toxic to all forms of aerobic life, inasmuch as it causes the inhibition of the mitochondrial respiratory chain, even though normal human cells have as a defense to its toxicity the rhodanese enzymes, which are found in low amounts in cancer cells. The authors also show that the antineoplastic action will have an e ciency of 80% at a tumor suspension concentration of 20 µg CN mL − 1 during the incubation of 2 hours in in vitro tests.…”

Section: Bioactive Secondary Compounds and Antioxidant Activitymentioning

confidence: 99%

“…Values of residual cyanide present in the our were extremely low (Table 3), with a variation of 0.50 to 4.20 mg kg − 1 in the Dry Class our, 0.99 to 4.70 mg kg − 1 in Fermented our samples and 4.12 to 15.60 mg kg − 1 in Mixed samples. Such ndings as to the presence of this compound can act positively and give greater visibility to the product, without the risk of food poisoning [28,40].…”

Section: Bioactive Secondary Compounds and Antioxidant Activitymentioning

confidence: 99%

Processing and quality of the cassava flour produced by traditional communities in the Central Amazon Region – Brazil

Nascimento

Mundim

Narcisa-Oliveira

et al. 2022

Preprint

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Cassava flour is a Brazilian product that still deserves attention for what regards sustainability. We offer a study of production processes and nutritional aspects of the flour from the Central Brazilian Amazon. We conducted bibliometric surveys, observations and collected 30 samples, in 15 traditional communities, that need cassava as a source of income and livelihood. We found that cassava cultivation under specific edaphoclimatic conditions guarantees the maintenance of autochthonous landraces. Still, we show their influence upon the flour's physicochemical composition, especially starch, mineral and fiber contents. Further, nutritional analyses allowed a qualitative approach of human health. We propose recommendations, such as: the mitigation of effects of residual cyanide, classifying the flour as safe food; the maintenance of traditional communities, and of genetic resources. Still, we suggest the adoption of a seal of approval and origin, and the creation of a gourmet market, thus adding visibility to Brazil's intangible heritage variety.

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“…As one of the forms of tumor cell regression, cyaniding acetone (CA) has been used. It is only possible to perform this approach because of its molar equivalent of cyanide that is anchored in neoplastic cells and these cannot eliminate cyanide due to the reduction of sulphane compound (RAMALHO et al, 2013;CEREDA, 2010). According to Essers (1993 apud RAMALHO; AYDOS; CEREDA, 2010), cyanide is commonly found in the environment and both men and animals can be exposed through different forms found such as in water, plastics, acrylics, cigarette smoke and cyanogenic plants.…”

Section: Cyanogenic Substancesmentioning

confidence: 99%

Action of Cyanogenic Substances and Magnetic Field in the Reduction of Neoplasms

Jabrayan¹,

Ramalho

Nascimento

et al. 2022

Int J Innov Educ Res

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Cancer treatment has been constantly improved to cause the least possible harm to the patient. New therapies are being researched, many of them having as object of scientific-academic and pharmacological research the use of cyanogenic plants and their antitumor chemical compounds that can bring benefits to human health, having the potential to be associated with the magnetic Field and thus achieve a better benefit and with reduced adverse effects in cancer treatment. This study aimed to review the effect of cyanogenic substances and magnetic Field on tumor evolution in the literature. The integrative review of the literature was carried out in the databases EMBASE, PUBMED, LILACS, VHL, SCOPUS and MEDLINE. A final sample of 14 scientific articles, published from 2011 to 2020, was obtained, highlighting that cyanogenic substances and the magnetic Field can help reduce tumors. The most common studies were on the magnetic Field, and the studies were carried out mainly in vitro, with a frequency of 50 Hz that stood out from the others. Among the cyanogenic substances, the most prevalent was tonsillin, with the most used dosage of 10mg / ml. It was possible to conclude that both the magnetic Field and cyanogenic substances can reduce tumors.

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Evaluation of acetone cyanohydrin effect in "in vitro" inativation of the Ehrlich ascites tumor cells

Cited by 8 publications

References 11 publications

Histopathological evaluation of tumor necrosis and volume after cyanogenic chemotherapy

Histopathological evaluation of tumor necrosis and volume after cyanogenic chemotherapy

Processing and quality of the cassava flour produced by traditional communities in the Central Amazon Region – Brazil

Action of Cyanogenic Substances and Magnetic Field in the Reduction of Neoplasms

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