Evaluation of a Wobbling Method Applied to Correcting Defective Pixels of CZT Detectors in SPECT Imaging

Abstract

In this paper, we propose a wobbling method to correct bad pixels in cadmium zinc telluride (CZT) detectors, using information of related images. We build up an automated device that realizes the wobbling correction for small animal Single Photon Emission Computed Tomography (SPECT) imaging. The wobbling correction method is applied to various constellations of defective pixels. The corrected images are compared with the results of conventional interpolation method, and the correction effectiveness is evaluated quantitatively using the factor of peak signal-to-noise ratio (PSNR) and structural similarity (SSIM). In summary, the proposed wobbling method, equipped with the automatic mechanical system, provides a better image quality for correcting defective pixels, which could be used for all pixelated detectors for molecular imaging.

Visualization of Fluoride Ions In Vivo Using a Gadolinium(III)-Coumarin Complex-Based Fluorescence/MRI Dual-Modal Probe

“…The disease biomarkers are often detected at all stages during diseases diagnostic and treatment, while such detection remains a challenge currently [3,4]. Molecular imaging enables visualization of disease biomarkers and their metabolisms in living systems in real time at various levels from molecules and single cells, to tissues, and organs, which allows detection and differential diagnosis of diseases [5,6]. Over the past decades, a variety of molecular imaging techniques, such as positron emission tomography (PET), X-ray computed tomography (CT), magnetic resonance imaging (MRI) and fluorescence imaging (FI), have been widely used in clinical diagnostics, biomedical research and molecular imaging fields [7,8,9,10].…”