Evaluation of a water-resistant and biocompatible adhesive with potential use in bone fractures

Cedano-Serrano, Francisco J; Pinzón, L. M.; Narváez, Diana; Paez, Cristian; Moreno-Serrano, Constanza L.; Tabima, Diana M.; Salcedo, Felipe; Briceño, Juan Carlos; Casas-Rodríguez, Juan Pablo

doi:10.1080/01694243.2016.1263055

Cited by 11 publications

(8 citation statements)

References 29 publications

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“…An effective bone adhesive would have a number of advantages, either as a complement to, or even as a replacement for, standard metallic implants. Tissue adhesives can directly bond to weak or osteoporotic bone surfaces, facilitate realignment and fixation of tissue fragments and reduce surgical time [ 9 ], facilitate early load bearing, and avoid detrimental stress related effects [ 8 , 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…The preclinical efficacy of calcified tissue adhesives has been evaluated using mechanical test models that include: shear force, on cubed bone tissue (i.e. cubes cut from fresh bone, and tested in shear by gluing the cube surfaces together before applying a shear force [ 12 , 17 , 26 ]; tensile loading [ 8 , 10 ]; or push-out, which is a commonly used test for adhesive bonding in dental applications [ 27 ]. In these studies the mechanical testing regimen did not reflect physiological loading, which is complex and may include bending, compression, shear and torsion [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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A biomechanical test model for evaluating osseous and osteochondral tissue adhesives

et al. 2019

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Background: Currently there are no standard models with which to evaluate the biomechanical performance of calcified tissue adhesives, in vivo. We present, herein, a pre-clinical murine distal femoral bone model for evaluating tissue adhesives intended for use in both osseous and osteochondral tissue reconstruction. Results: Cylindrical cores (diameter (Ø) 2 mm (mm) × 2 mm depth), containing both cancellous and cortical bone, were fractured out from the distal femur and then reattached using one of two tissue adhesives. The adhesiveness of fibrin glue (Tisseel tm ), and a novel, biocompatible, calcium phosphate-based tissue adhesive (OsStic tm ) were evaluated by pullout testing, in which glued cores were extracted and the peak force at failure recorded. The results show that Tisseel weakly bonded the metaphyseal bone cores, while OsStic produced > 30-fold higher mean peak forces at failure (7.64 Newtons (N) vs. 0.21 N). The failure modes were consistently disparate, with Tisseel failing gradually, while OsStic failed abruptly, as would be expected with a calcium-based material. Imaging of the bone/ adhesive interface with microcomputed tomography revealed that, for OsStic, failure occurred more often within cancellous bone (75% of tested samples) rather than at the adhesive interface.Conclusions: Despite the challenges associated with biomechanical testing in small rodent models the preclinical ex-vivo test model presented herein is both sensitive and accurate. It enabled differences in tissue adhesive strength to be quantified even for very small osseous fragments (<Ø4mm). Importantly, this model can easily be scaled to larger animals and adapted to fracture fragment fixation in human bone. The present model is also compatible with other long-term in vivo evaluation methods (i.e. in vivo imaging, histological analysis, etc.).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A biomechanical test model for evaluating osseous and osteochondral tissue adhesives

et al. 2019

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“…Although different approaches in terms of biomimetic synthetic and hybrid concepts have been pursued to prepare bone adhesives [24,46,47,48], to this date, there has been no commercially available bone adhesive that meets all the above-mentioned requirements [49], but we are getting closer to wide clinical applications and are curious for mid- and long term results.…”

Section: Necessary Properties For Bone Adhesivesmentioning

confidence: 99%

“…It formed hydrogels and revealed increased underwater strength over time in the presence of calcium carbonate while simultaneously showing excellent adhesions at all times tested. Finally, it was observed that the hydrogel lead to normal cell growth and good cell differentiation on the adhesive surface, making it a promising candidate for the treatment of bone fractures [46].…”

Section: Development Of Approaches For the Generation Of Bone Adhementioning

confidence: 99%

Current State of Bone Adhesives—Necessities and Hurdles

et al. 2019

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The vision of gluing two bone fragments with biodegradable and biocompatible adhesives remains highly fascinating and attractive to orthopedic surgeons. Possibly shorter operation times, better stabilization, lower infection rates, and unnecessary removal make this approach very appealing. After 30 years of research in this field, the first adhesive systems are now appearing in scientific reports that may fulfill the comprehensive requirements of bioadhesives for bone. For a successful introduction into clinical application, special requirements of the musculoskeletal system, challenges in the production of a bone adhesive, as well as regulatory hurdles still need to be overcome. In this article, we will give an overview of existing synthetic polymers, biomimetic, and bio-based adhesive approaches, review the regulatory hurdles they face, and discuss perspectives of how bone adhesives could be efficiently introduced into clinical application, including legal regulations.

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“…In particular, in the first case, the adhesive material must not impair fracture healing by forming a rigid barrier, which is enabled while applying the bone adhesive only selectively or by using biodegradable materials. Recent approaches to create bone adhesives include cyanoacrylates [3,4], methacrylates [5,6,7], fibrin glue [8], mussel proteins and dopamine hydrogels [9,10,11], or polysaccharides [12,13,14]. Most synthetic materials that have been tested as bone-bonding agents, are either mechanically weak with insufficient adhesion to the bone surface or do not fulfill the requirement of biodegradability, as for example poly(methyl methacrylate) (PMMA), cyanoacrylates and its associated formulations [15].…”

Section: Introductionmentioning

confidence: 99%

Magnesium Phosphate Cement as Mineral Bone Adhesive

et al. 2019

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Mineral bone cements were actually not developed for their application as bone-bonding agents, but as bone void fillers. In particular, calcium phosphate cements (CPC) are considered to be unsuitable for that application, particularly under moist conditions. Here, we showed the ex vivo ability of different magnesium phosphate cements (MPC) to adhere on bovine cortical bone substrates. The cements were obtained from a mixture of farringtonite (Mg3(PO4)2) with different amounts of phytic acid (C6H18O24P6, inositol hexaphosphate, IP6), whereas cement setting occurred by a chelation reaction between Mg2+ ions and IP6. We were able to show that cements with 25% IP6 and a powder-to-liquid ratio (PLR) of 2.0 g/mL resulted in shear strengths of 0.81 ± 0.12 MPa on bone even after 7 d storage in aqueous conditions. The samples showed a mixed adhesive–cohesive failure with cement residues on the bone surface as indicated by scanning electron microscopy and energy-dispersive X-ray analysis. The presented material demonstrated appropriate bonding characteristics, which could enable a broadening of the mineral bone cements’ application field to bone adhesives.

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Evaluation of a water-resistant and biocompatible adhesive with potential use in bone fractures

Cited by 11 publications

References 29 publications

A biomechanical test model for evaluating osseous and osteochondral tissue adhesives

A biomechanical test model for evaluating osseous and osteochondral tissue adhesives

Current State of Bone Adhesives—Necessities and Hurdles

Magnesium Phosphate Cement as Mineral Bone Adhesive

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