“…15,[19][20][21][22]24 Using NCA, Davis et al 19 showed that 33%, 46%, and 63% of patients receiving conventional weight-based dosing were estimated to have achieved an AUC within the target ranges of 4800 μM*min ±10%, ±15%, and ±20%, respectively. 19 Following a PK-guided test-dose procedure, 50%, 75%, and 94% of patient AUCs were within the AUC target ±10%, ±15%, and ±20% ranges, respectively. In our study, the proportion of patient AUCs, estimated using NCA, within these ranges are consistent with the results reported by Davis et al However, we demonstrate that busulfan PK among adult allo-HCT recipients receiving MAC dosing can be reasonably described by a popPK model.…”