Evaluation of a soybean product fujiflavone P40 as an antiosteoporotic agent in rats

Abstract

The preventive effects of Fujiflavone P40 (a soybean isoflavone product) against both bone loss and periodontal alteration were evaluated using an ovariectomized rat model. Rats were divided into five groups: sham-operated (Sham), ovariectomized (OVX), OVX given Fujiflavone P40, OVX given 17beta-oestradiol, and OVX given the vehicle for 17beta-oestradiol, respectively. Fujiflavone P40 contains 46.6% isoflavones which consist of 24.1% daidzin, 16.5% glycitin and 5.9% genistin. Administration of Fujiflavone P40 to OVX rats suppressed the body weight gain until 5 weeks. Fujiflavone P40 also decreased total and high-density lipoprotein (HDL) cholesterols and triglyceride level of OVX rats, significantly. After 7 weeks, Fujiflavone P40 did not recover the coarsened fibre of the periodontal ligament. The ovariectomy decreased the uterine weight by 78%. The administration of 17beta -oestradiol recovered the weight loss by 99%, while Fujiflavone P40 restored it by 33%. The ovariectomy decreased the tibial bone mineral density (BMD) by 22%. The administration of 17beta-oestradiol to OVX rats recovered the tibial BMD decrease by 100%, while Fujiflavone P40 recovered it by 78%. The results suggest that Fujiflavone P40 may be useful as a preventive agent for osteoporosis.

Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia

“…Fujiflavone P40 (a product of isoflavone from soybeans) was kindly supplied by Fujicco (Kobe, Japan) [21]. Capsaicin was purchased from Sigma Chemical Co. (St. Louis, MO).…”

Effects of Dietary Intake of Isoflavone Aglycone-rich Fermented Soybeans on Bone Metabolism in Ovariectomized Rats

“…Deyhim et al 32) reported that at a low dose (about 0.014%), isoflavones had no effect on bone mineral contents in such a short time. Using the same dose of isoflavones as we used in the present study, Hidaka et al 33) reported that a 7-week intake improved the tibial bone density. Therefore, we extended the intake period to 8 weeks in this study and clearly confirmed the bone-sparing effects of FS.…”

Optimal parameters for lateral oblique radiographs of rat mandibles

“…3 Radiographic studies with rats have used mammography films, 5 dental radiography films, [10][11][12] intraoral 4 or oclusal, 12,13 and low kilovoltage X-ray sources. [14][15][16] These studies do not seem to have reached satisfactory results -as they were not employed in more recent studies -and other methods to obtain images, such as X-ray absorptiometry, bone densitometry [17][18][19][20][21] and micro X-ray CT [22][23][24][25] have been investigated. However, these methods require special installations for their use with animals and have a high operational cost.…”