Evaluation of a small flat rectangular therapeutic ultrasonic transducer intended for intravascular use

Papadopoulos, N.; Menikou, Georgios; Yiannakou, Marinos; Yiallouras, Christos; Ioannides, Kleanthis; Damianou, Christakis

doi:10.1016/j.ultras.2016.10.014

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Atherosclerosis causes noninflammatory, degenerative, and proliferative lesions of blood vessels, increasing the incidence of cardiovascular and cerebrovascular diseases [2][3][4]. Pathological diagnosis showed that intravascular thrombosis and stenosis are the main characteristics of atherosclerosis [5]. In recent years, percutaneous coronary intervention (PCI) is often applied to treat patients with coronary artery stenosis caused by atherosclerosis [6].…”

Section: Introductionmentioning

confidence: 99%

Delivery of miR-654-5p via SonoVue Microbubble Ultrasound Inhibits Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells and Arterial Thrombosis and Stenosis through Targeting TCF21

Wang

Tang

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Background. Abnormal proliferation of vascular smooth muscle cells (VSMCs) is an important cause of vascular stenosis. The study explored the mechanism of inhibition of vascular stenosis through the molecular mechanism of smooth muscle cell phenotype transformation. Methods. Coronary heart disease-related genes were screened by bioinformatics, and the target genes of miR-654-5p were predicted by dual-luciferase method and immunofluorescence method. miR-654-5p mimic stimulation and transfection of TCF21 and MTAP into cells. SonoVue microbubble sonication was used to deliver miR-654-5p into cells. Cell proliferation, migration, and invasion were detected by CCK-8, wound scratch, and Transwell. HE and IHC staining were performed to study the effect of miR-654-5p delivery via SonoVue microbubble ultrasound on vessel stenosis in a model of arterial injury. Gene expression was determined by qRT-PCR and WB. Results. TCF21 and MTAP were predicted as the target genes of miR-654-5p. Cytokines induced smooth muscle cell proliferation, migration, and invasion and promoted miR-654-5p downregulation; noticeably, downregulated miR-654-5p was positively associated with the cell proliferation and migration. Overexpression of TCF21 promoted proliferation, invasion, and migration, and mimic reversed such effects. miR-654-5p overexpression delivered by SonoVue microbubble ultrasound inhibited proliferation, migration, and invasion of cells. Moreover, in arterial injury model, we found that SonoVue microbubble ultrasound transmitted miR-654-5p into the arterial wall to inhibit arterial thrombosis and stenosis, while TCF21 was inhibited. Conclusion. Ultrasound delivery of miR-654-5p via SonoVue microbubbles was able to inhibit arterial thrombosis and stenosis by targeting TCF21.

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Section: Introductionmentioning

confidence: 99%

Delivery of miR-654-5p via SonoVue Microbubble Ultrasound Inhibits Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells and Arterial Thrombosis and Stenosis through Targeting TCF21

Wang

Tang

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…In our previous studies, we used oleic acid modified Fe 3 O 4 to construct nanoparticles (NPs), and these NPs had good MR negative contrast enhancement for arterial thrombosis. , Phase-transition agents have been successfully used in US molecular imaging to enhance the imaging effect. In addition, a series of biological effects, such as sonoporation and cavitation effects, are generated in the process of the phase transition and have the potential to treat tumors and cardiovascular diseases. , Zhu et al successfully developed a novel NP combining low-intensity focused ultrasound (LIFU) with an intracellular “explosion effect” caused by the acoustic droplet vaporization (ADV) effect, realizing precise tumor therapy . In the process of ADV, a series of violent dynamic processes such as oscillation, expansion, contraction, and even the collapse of tiny bubbles in the liquid under the action of sound waves are generated, thereby generating phenomena such as chemical reactions, luminescence, and subharmonics.…”

Section: Introductionmentioning

confidence: 99%

SR-A-Targeted Phase-Transition Nanoparticles for the Detection and Treatment of Atherosclerotic Vulnerable Plaques

Ye¹,

Zhou²,

Zhong³

et al. 2019

ACS Appl. Mater. Interfaces

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Atherosclerosis is a major cause of sudden death and myocardial infarction, instigated by unstable plaques. Thus, the early detection of unstable plaques and corresponding treatment can improve the prognosis and reduce mortality. In this study, we describe a protocol for the preparation of nanoparticles (NPs) combined with the phase transitional material perfluorohexane (PFH) and with dextran sulfate (DS) targeting class A scavenger receptors (SR-A) for the diagnosis and treatment of atherosclerotic vulnerable plaques. The results showed that the Fe-PFH-poly(lactic-co-glycolic acid) (PLGA)/chitosan (CS)-DS NPs were fabricated successfully, with the ability to undergo phase transition by low-intensity focused ultrasound (LIFU) irradiation to achieve ultrasound imaging; a high carrier rate of Fe 3 O 4 had a good negative enhancement effect on magnetic resonance imaging (MRI). The NPs had a high binding affinity for activated macrophages and could be endocytosed by the macrophages and notably induced apoptosis under LIFU irradiation by an acoustic droplet vaporization effect in vitro. Furthermore, in an ex vivo atherosclerotic plaque model of apolipoprotein E knockout (KO) (apoE −/− ) mice induced by high cholesterol, the NPs selectively accumulated at the sites of SR-A expressed on the activated macrophages of the aortic region. This result was also confirmed by MRI in vivo, where the NPs could be targeted to the aortic plaque and reduced the T 2 * signal. The LIFU-induced phase transition could lead to the apoptosis of macrophages on plaques in vivo. In summary, Fe-PFH-PLGA/CS-DS NPs may be applied as multimodal and multifunctional probes and are expected to enable the specific diagnosis and targeted therapy of vulnerable plaques.

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Multifunctional pathology-mapping theranostic nanoplatforms for US/MR imaging and ultrasound therapy of atherosclerosis

Gao

Zhou

et al. 2021

Nanoscale

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Evaluation of a small flat rectangular therapeutic ultrasonic transducer intended for intravascular use

Cited by 4 publications

References 30 publications

Delivery of miR-654-5p via SonoVue Microbubble Ultrasound Inhibits Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells and Arterial Thrombosis and Stenosis through Targeting TCF21

Delivery of miR-654-5p via SonoVue Microbubble Ultrasound Inhibits Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells and Arterial Thrombosis and Stenosis through Targeting TCF21

SR-A-Targeted Phase-Transition Nanoparticles for the Detection and Treatment of Atherosclerotic Vulnerable Plaques

Multifunctional pathology-mapping theranostic nanoplatforms for US/MR imaging and ultrasound therapy of atherosclerosis

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