Evaluation of a Single Dose Intravenous Paracetamol for Pain Relief After Maxillofacial Surgery: A Randomized Clinical Trial Study

Eftekharıan, Hamıd Reza; Kazemi, Hamidreza; Nili, Mahsa

doi:10.1007/s12663-013-0557-9

Cited by 4 publications

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“…Furthermore, patients who underwent mandibular surgery reported higher pain and required more analgesic drugs than those who underwent only maxillary surgery [ 23 ]. A single dose of intravenous paracetamol could relief the pain after surgery for mandibular fractures [ 19 ]. It has been reported that there was a similar efficacy between a single dose of 1 g intravenous paracetamol and 75 mg intramuscular diclofenac sodium in postoperative pain control for orthognathic surgery [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…The sample size was calculated using the formula for a randomized controlled trial [ 22 ] based on the visual analogue scale pain intensity from a previous study [ 19 ] (mean in the treatment group = 3.98, SD. in the treatment group = 0.69, mean in the control group = 4.63, SD.…”

Section: Methodsmentioning

confidence: 99%

“…ERAS encourages practitioners to decrease the use of opioid analgesics (to reduce the drug's side effects and the length of stay) and use opioid-sparing methods, such as regional anesthesia, paracetamol, NSAIDs, and other analgesic adjuvant drugs, instead [ 5 ]. There are some studies regarding using an MA strategy in orthognathic surgery [ 17 , 18 ] and the efficacy of intravenous paracetamol in orthognathic surgery and maxillofacial surgery pain control [ 19 , 20 ]. The results seemed to be effective for the pain relief and decreasing opioid usage.…”

Section: Introductionmentioning

confidence: 99%

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Single Dose Intravenous Paracetamol versus Placebo in Postorthognathic Surgery Pain: A Randomized Clinical Trial

Sumphaongern,

Jansisyanont

2024

Anesthesiology Research and Practice

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Background. The postorthognathic surgery patients experienced moderate to severe pain and could be at risk for opioid-related side effects. The aim of this study was to evaluate the efficacy of a single dose of intravenous paracetamol to control postorthognathic surgery pain and reduce opioid consumption. Methods. The patients were randomized into two groups. The study group received intravenous paracetamol and the control group received a placebo immediately postoperation. The visual analogue pain scale (VAS) at 1-, 4-, 8-, 12-, 16-, 20-, and 24 -h postoperatively, morphine consumption, side effects from morphine, and patient satisfaction were analyzed. Results. Sixty-two patients (thirty-one patients in each group) were included. The postoperative VAS in the study group was significantly lower than those in the control group (p value <0.001) at all time points. The total postoperative morphine consumption in the study group (45.1 ± 21.2 mcg/kg) was significantly lower compared with the control group (136.5 ± 49.9 mcg/kg) (p value <0.001). Patient satisfaction was significantly higher in the study group (4.7 ± 0.5 out of 5 points) than in the control group (4.1 ± 0.7 out of 5 points) (p value <0.001). The incidence of nausea and vomiting was significantly lower in the study group compared with the control group (p value <0.001 and 0.002, respectively). Conclusion. A single dose of intravenous paracetamol as part of multimodal analgesia was effective for postorthognathic surgery pain. It provided significant benefits to patients, including reduced pain scores, decreased opioid consumption, reduced nausea and vomiting, and improved satisfaction. This trial is registered with TCTR20210908002.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Single Dose Intravenous Paracetamol versus Placebo in Postorthognathic Surgery Pain: A Randomized Clinical Trial

Sumphaongern,

Jansisyanont

2024

Anesthesiology Research and Practice

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“…Parasetamol memiliki kelebihan dibandingkan Non-steroidal anti-inflammatory drugs (NSAID) karena NSAID konvensional dapat berkaitan dengan efek serius yang tidak diinginkan seperti perdarahan atau gangguan pada ginjal apabila digunakan sebelum tindakan operasi. 17 Parasetamol intravena merupakan obat pereda nyeri yang efektif dalam mengontrol rasa sakit saat keadaan darurat juga pasca operasi. 18 Tindakan operasi dilakukan dalam anestesi umum.…”

Section: Pembahasanunclassified

<p>Penatalaksanaan kegawatdaruratan medis trauma maksilofasial pada anak disertai cedera kepala</p><p>Emergency management of maxillofacial trauma in children with a head injury</p>

2021

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Pendahuluan: Pasien dengan fraktur maksilofasial mempunyai risiko tinggi disertai cedera kepala karena dekatnya letak anatomi tulang wajah dan kranium. Trauma maksilofasial sering menyebabkan cedera pada jaringan lunak, gigi geligi dan komponen utama rangka wajah termasuk mandibula, maksila, zigoma, kompleks nasoorbital-ethmoid (NOE) dan struktur supraorbital. Kegawatdaruratan medis pada anak merupakan suatu kondisi yang mendesak yang membutuhkan penanganan segera pada anak untuk mengurangi resiko kematian dan kecacatan. Laporan kasus ini bertujuan agar memberikan gambaran dan mengevaluasi tindakan pasien trauma maksilofasial yang disertai cedera kepala pada anak. Laporan kasus: Seorang anak laki-laki usia 9 tahun datang dengan keluhan perdarahan dari mulut, 3 jam karena terjatuh saat mengendarai sepeda. Pasien mengalami cedera kepala dan fraktur dentoalveolar rahang atas dan rahang bawah. Diagnosis cedera kepala ringan, fraktur palatum inkomplit, fraktur dentoalveolar regio gigi 54-21, 85-32 dengan fraktur segmental dentoalveolar regio gigi 42-83 disertai avulsi gigi 11,12,53,54,21,32,31,41,84 dan mobility grade 3 gigi 42,83,85, luka laserasi pada regio frontal, labii inferior, palatum, mentale dan gingiva regio gigi 54-21 dan 85-32, serta luka punctum pada regio labiomental. Penatalaksanaan kasus ini adalah dilakukan pembersihan luka, ekstraksi gigi 83, 85, 42, alveolektomi regio gigi 54-21, 32-85 serta penjahitan pada luka laserasi dan punctum dengan melibatkan bagian bedah saraf, ilmu kesehatan anak dan anestesi. Simpulan: Penatalaksanaan kegawatdaruratan medis cedera kepala dan trauma maksilofasial pada kasus ini dilakukan penjahitan pada intra oral dan ekstra oral serta ekstraksi gigi 42,83,85 dengan anestesi umum yang melibatkan bagian bedah saraf, ilmu kesehatan anak, anestesi dapat mencegah kematian dan mengurangi resiko kecacatan yang lebih parah. Penilaian awal secara komprehensif sangat penting dalam menentukan rencana perawatan kegawat daruratan pada pasien trauma maksilofasial.Kata kunci: Cedera kepala, trauma maksilofasial, kegawatdaruratan medis anak ABSTRACTIntroduction: Patients with maxillofacial fractures are at a high risk of head injury due to the cranium and facial bones' anatomy. Maxillofacial trauma often causes injury to soft tissues, teeth, and significant facial skeleton components, including the mandible, maxilla, zygoma, nasoorbitoethmoid (NOE) complex and supraorbital structures. A paediatric medical emergency is an urgent condition that requires immediate treatment to reduce the risk of death and disability. This case report was aimed to provide an overview and evaluation of the treatment for child patient with maxillofacial trauma accompanied by head injuries. Case report: A 9-year-old male child presented with complaints of bleeding from the mouth, 3 hours after falling while riding a bicycle. The patient had head injuries and dentoalveolar fractures of the maxilla and mandible. Diagnosis of minor head injury, incomplete palatal fracture, dentoalveolar fracture of teeth number 54-21, 85-32 with segmental fracture of the dentoalveolar region of teeth number 42-83 accompanied by avulsion in teeth number 11, 12, 53, 54, 21, 32, 31, 41, 84, and mobility grade 3 of teeth number 42, 83, 85. Laceration wounds in the frontal region, inferior labii, palate, mentale, and gingiva regions of teeth number 54-21 and 85-32, and punctum wounds in the labiomental region. This case management included rinsing the wound; extracting teeth number 83, 85, 42; alveolectomy in the region of teeth number 54-21, 32-85; suturing the laceration and punctum wounds involving neurosurgery, paediatric medicine and anaesthesia. Conclusion: Management of medical emergency of head injury and maxillofacial trauma in this case is performed with intraoral and extraoral suturing and extraction of teeth number 42, 83, 85, with general anaesthesia involving the Neurosurgery and Paediatrics Division. Anaesthesia can prevent death and reduce the more severe risk of disability. A comprehensive initial assessment is essential in determining the emergency treatment plan for maxillofacial trauma patients.Keywords: Head injury, maxillofacial trauma, paediatric medical emergency.

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Medical Complications Following Maxillofacial Surgery

Ward

2017

Complications in Maxillofacial Cosmetic Surgery

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Evaluation of a Single Dose Intravenous Paracetamol for Pain Relief After Maxillofacial Surgery: A Randomized Clinical Trial Study

Abstract: Paracetamol is effective on pain relief after maxillofacial surgeries. Operation time may be an important factor for induction of pain after the surgeries.

Cited by 4 publications

References 24 publications

Single Dose Intravenous Paracetamol versus Placebo in Postorthognathic Surgery Pain: A Randomized Clinical Trial

Single Dose Intravenous Paracetamol versus Placebo in Postorthognathic Surgery Pain: A Randomized Clinical Trial

<p>Penatalaksanaan kegawatdaruratan medis trauma maksilofasial pada anak disertai cedera kepala</p><p>Emergency management of maxillofacial trauma in children with a head injury</p>

Medical Complications Following Maxillofacial Surgery

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