Evaluation of a silicon photomultiplier PET insert for simultaneous PET and MR imaging

Ko, Gyung Hyuck; Kim, Kyeong Yun; Yoon, Hyun Sun; Lee, Min Sun; Son, Jeong Whan; Im, Hyung Jun; Lee, Jae Sung

doi:10.1118/1.4937784

Cited by 50 publications

(61 citation statements)

References 37 publications

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“…The developed SiPM PET system achieves submillimeter spatial resolution in the center of the FOV (0.7 mm in-plane using iterative image reconstruction of a point source in air) desired for rodent brain imaging and high peak system sensitivity (.3%) desired for dynamic PET studies with short-lived radiotracers and short time frames (22). Our new PET system neither significantly degrades the MRI information nor is affected by MRI acquisition.…”

Section: Discussionmentioning

confidence: 99%

“…The PET insert yields superb performance for small-animal imaging (22). The radial/tangential/axial resolutions estimated from reconstructed point source images using ordered-subset expectation maximization were 0.75/0.68/1.05 mm at the center of the FOV and 1.46/0.71/ 1.22 mm at the 14-mm radial off-center.…”

Section: Mr-compatible Sipm Pet Systemmentioning

confidence: 97%

“…We also implemented a real-time gain compensation module based on the temperature monitoring and bias voltage feedback to maintain uniform performance (22). The real-time adjustment of bias voltage yielded stable photopeak positions (,0.5% variation), energy resolutions (average energy resolution was maintained at 14.2% despite the temperature variation), and prompt counting rates (,1.2% variation) over a wide temperature range (10°C-30°C).…”

Section: Mr-compatible Sipm Pet Systemmentioning

confidence: 99%

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Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging

Yoon

Kim

et al. 2016

J Nucl Med

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Visualization of biologic processes at molecular and cellular levels has revolutionized the understanding and treatment of human diseases. However, no single biomedical imaging modality provides complete information, resulting in the emergence of multimodal approaches. Combining state-of-the-art PET and MRI technologies without loss of system performance and overall image quality can provide opportunities for new scientific and clinical innovations. Here, we present a multiparametric PET/MR imager based on a smallanimal dedicated, high-performance, silicon photomultiplier (SiPM) PET system and a 7-T MR scanner. Methods: A SiPM-based PET insert that has the peak sensitivity of 3.4% and center volumetric resolution of 1.92/0.53 mm 3 (filtered backprojection/ordered-subset expectation maximization) was developed. The SiPM PET insert was placed between the mouse body transceiver coil and gradient coil of a 7-T small-animal MRI scanner for simultaneous PET/MRI. Mutual interference between the MRI and SiPM PET systems was evaluated using various MR pulse sequences. A cylindric corn oil phantom was scanned to assess the effects of the SiPM PET on the MR image acquisition. To assess the influence of MRI on the PET imaging functions, several PET performance indicators including scintillation pulse shape, flood image quality, energy spectrum, counting rate, and phantom image quality were evaluated with and without the application of MR pulse sequences. Simultaneous mouse PET/MRI studies were also performed to demonstrate the potential and usefulness of the multiparametric PET/MRI in preclinical applications. Results: Excellent performance and stability of the PET system were demonstrated, and the PET/MRI combination did not result in significant image quality degradation of either modality. Finally, simultaneous PET/MRI studies in mice demonstrated the feasibility of the developed system for evaluating the biochemical and cellular changes in a brain tumor model and facilitating the development of new multimodal imaging probes. Conclusion: We developed a multiparametric imager with high physical performance and good system stability and demonstrated its feasibility for small-animal experiments, suggesting its usefulness for investigating in vivo molecular interactions of metabolites, and cross-validation studies of both PET and MRI.Key Words: PET/MRI; silicon photomultiplier (SiPM); hybrid imaging; multi-parametric imaging; dual-modality imaging probe Asubst antial role of small-animal imaging has been pinpointed in numerous studies in terms of understanding the underlying mechanism of human diseases and elucidating the efficacy of new therapeutic approaches. Among the in vivo small-animal imaging modalities, which are scaled down to dedicated devices from clinical ones, PET is the most-sensitive technique that is readily translatable to the clinic (1). Spatial and temporal distributions of compounds labeled with a positron-emitting radionuclide are noninvasively measured by the PET scanner. Consequently, the PET scanner p...

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Section: Discussionmentioning

confidence: 99%

Section: Mr-compatible Sipm Pet Systemmentioning

confidence: 97%

Section: Mr-compatible Sipm Pet Systemmentioning

confidence: 99%

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Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging

Yoon

Kim

et al. 2016

J Nucl Med

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“…SiPM is widely believed to be the future photodetector for PET scanners . Clinic whole body PET scanners and preclinical PET scanners were already built with SiPM based detectors . But so far only a few studies were done on dual‐ended readout PET detector development with SiPMs and all of those studies used crystal size of 1.5 mm or bigger .…”

Section: Introductionmentioning

confidence: 99%

“…25,26 Clinic whole body PET scanners 27 and preclinical PET scanners were already built with SiPM based detectors. [28][29][30] But so far only a few studies were done on dual-ended readout PET detector development with SiPMs and all of those studies used crystal size of 1.5 mm or bigger. 21,[31][32][33] The focus of this work is to develop high resolution, high efficient and high DOI resolution small animal PET detectors using dual-ended readout of pixelated LYSO arrays optically coupled with SiPM arrays.…”

Section: Introductionmentioning

confidence: 99%

Development of depth encoding small animal PET detectors using dual‐ended readout of pixelated scintillator arrays with SiPMs

et al. 2017

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Systematic study on factors influencing the performance of interdetector scatter recovery in small‐animal PET

Lee

Kim

et al. 2018

Medical Physics

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As a fundamental research for real implementation of IDS recovery, we conducted a simulation study to evaluate the factors affecting sensitivity increase, recovery accuracy, and image quality. Sensitivity increase was dependent on the energy window and energy resolution, while the recovery accuracy was affected by energy window, recovery scheme, energy resolution, and DOI capability. In image quality analysis, sensitivity increase and recovery accuracy dominantly affected the noise and quantitative accuracy, respectively. Among the recovery schemes, the proportional scheme obtained the best image quality.

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Evaluation of a silicon photomultiplier PET insert for simultaneous PET and MR imaging

Abstract: The developed MR-compatible PET insert is designed for insertion into a narrow-bore magnetic resonance imaging scanner, and it provides excellent imaging performance for PET/MR preclinical studies.

Cited by 50 publications

References 37 publications

Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging

Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging

Development of depth encoding small animal PET detectors using dual‐ended readout of pixelated scintillator arrays with SiPMs

Systematic study on factors influencing the performance of interdetector scatter recovery in small‐animal PET

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