Evaluation of a series of phenyl-type stationary phases in supercritical fluid chromatography with the linear solvation energy relationship model and its application to the separation of phenolic compounds

Jiang, Dasen; Ke, Yanxiong; Cai, Jianfeng; Zhang, Huanhuan; Fu, Qing; Liang, Xinmiao

doi:10.1016/j.chroma.2019.460700

Cited by 14 publications

(4 citation statements)

References 29 publications

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“…In 2020, Jiang et al studied the retention mechanism for a series of synthesized phenyl‐type stationary phases with different substituted benzenes using original LSER models with a set of more than 90 compounds. 161 The obtained LSER models showed a good fit to the data set with a maximum correlation coefficient value of 0.992 and a maximum standard deviation of 0.255. In addition, it was found that compared to the ODS, the phenyl‐type stationary phases were able to provide all types of interaction with different strengths, and thus can provide a wide range of selectivity.…”

Section: Psfc Retention Mechanism Studiesmentioning

confidence: 80%

“…Moreover, the proposed global model highlighted the impact of compound physicochemical properties on the retention behavior under gradient conditions. In 2020, Jiang et al studied the retention mechanism for a series of synthesized phenyl‐type stationary phases with different substituted benzenes using original LSER models with a set of more than 90 compounds 161 . The obtained LSER models showed a good fit to the data set with a maximum correlation coefficient value of 0.992 and a maximum standard deviation of 0.255.…”

Section: Psfc Retention Mechanism Studiesmentioning

confidence: 99%

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A review of retention mechanism studies for packed column supercritical fluid chromatography

Si-Hung

Bamba

2021

Analytical Science Advances

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The packed column supercritical fluid chromatography has risen as a promising alternative separation technique to the conventional liquid chromatography and gas chromatography. Although the packed column supercritical fluid chromatography has many advantages compared to other chromatographic techniques, its separation mechanism is not fully understood due to the complex combination effects of many chromatographic parameters on separation quality and the lacking of global strategies for studying separation mechanisms. This review aims to provide recent information regarding the chromatographic behaviors and the effects of the parameters on the separation, discuss the results, and point out the remaining bottlenecks in the packed column supercritical fluid chromatography retention mechanism studies.

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Section: Psfc Retention Mechanism Studiesmentioning

confidence: 80%

Section: Psfc Retention Mechanism Studiesmentioning

confidence: 99%

A review of retention mechanism studies for packed column supercritical fluid chromatography

Si-Hung

Bamba

2021

Analytical Science Advances

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“…A simple way to estimate the contribution of partitioning and adsorption to retention is to plot logk against the volume percentage of the co-solvent in the mobile phase and fit the data to the logk-φ or logk-logφ coordinates representing the partitioning and adsorption regimes respectively (64). The most popular QSRR method for processing retention data of many solutes aimed at column selection is the linear solvation energy relationship (LSER) modeling including Abraham descriptors (65,66).…”

Section: Column Chemistry: Retention and Selectivitymentioning

confidence: 99%

Leveraging the power of supercritical fluid chromatography for eco-conscious solutions in pharmaceutical analysis

Krmar,

Svrkota,

Obradović

et al. 2024

Arhiv za farmaciju

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Initially employed primarily at a preparative scale for enantiomer separation of chiral drug candidates, Supercritical Fluid Chromatography (SFC) is nowadays extensively used in the analytical mode. Recent advances in SFC separation science have emphasized its potential for modern and environmentally friendly pharmaceutical analysis. The aim of this review is to provide a deeper insight into the main fundamental and practical aspects of the SFC technique in order to familiarize readers with its versatile nature and efficiency in creating sustainable chromatographic solutions. All considerations are made primarily in the context of the most widely used mode of operation - achiral SFC. In addition, recent applications of this promising technique are presented at the end of the article to further promote its use in pharmaceutical analytical practice.

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“…A quite wide range of stationary phases has been applied to the SFC separation of TCMs. Besides traditional bare silica and modified silica‐based stationary phases like diol, amino, amide, and cyanopropyl, other types of stationary phases designed for SFC such as 2‐ethylpyridine (2‐EP), diethylamine (DEA), 2‐picolylamine (2‐PIC), and 1‐aminoanthracene (1‐AA) also performed well [14–16]. Moreover, the feasibility of using chiral stationary phases in the separation of structural analogues in TCMs was proved [17, 18].…”

Section: Introductionmentioning

confidence: 99%

Separation and characterization of phenylamides fromPiper kadsurausing preparative supercritical fluid chromatography and ultra‐high‐performance supercritical fluid chromatography‐tandem mass spectrometry

Dai

Jiang

Dai

et al. 2021

J of Separation Science

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A preparative supercritical fluid chromatography method for the separation of Piper kadsura obtained five phenylamide compounds, which had the same structural skeleton, but changed in the number and position of methoxyl substituents. To improve the separation selectivity of these structural analogues, silica, phenyl, and chiral stationary phases were screened. Only through the combination of Chiral C and phenyl columns could the separation of the five phenylamides be solved. The two‐step strategy using preparative supercritical fluid chromatography presented good orthogonality that ensured the purity of the phenylamides. Then, an ultra‐high‐performance supercritical fluid chromatography hyphened tandem mass spectrometry method was developed, and the fragmentation pattern of phenylamides was summarized. It mainly cleaved in the amide bond to produce the fragment ion, which could help to judge the substituent positions. Twenty‐eight possible molecular weights of hydroxyl and methoxyl substituted phenylamides were calculated and screened. Nine compounds were extracted in three [M + H]+ ions at m/z 284.13, 314.13, and 344.13, including five purified compounds and the other four positional or trans‐cis phenylamide isomers in low content. The methods developed in this research were useful in the separation and characterization of phenylamide analogues.

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Evaluation of a series of phenyl-type stationary phases in supercritical fluid chromatography with the linear solvation energy relationship model and its application to the separation of phenolic compounds

Cited by 14 publications

References 29 publications

A review of retention mechanism studies for packed column supercritical fluid chromatography

A review of retention mechanism studies for packed column supercritical fluid chromatography

Leveraging the power of supercritical fluid chromatography for eco-conscious solutions in pharmaceutical analysis

Separation and characterization of phenylamides fromPiper kadsurausing preparative supercritical fluid chromatography and ultra‐high‐performance supercritical fluid chromatography‐tandem mass spectrometry

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