Evaluation of a rapid theophylline test strip assay in the emergency department setting

Hurley, William T.; Saglio, S D; Henley, Charles E.; Gatrell, Cloyd B.

doi:10.1016/s0196-0644(88)80440-2

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…We found a better correlation when the test was made by physicians than did Hurley et al (1988), but, as they did, we recommend that as few persons as possible run the test. Nevertheless, minimal training enables most medical personnel to perform the test properly.…”

Section: Discussionmentioning

confidence: 56%

“…Nevertheless, minimal training enables most medical personnel to perform the test properly. We found a better correlation when the test was made by physicians than did Hurley et al (1988), but, as they did, we recommend that as few persons as possible run the test. In addition, it is important to keep the AccuLevel kits in the refrigerator until immediately before use.…”

Section: Discussionmentioning

confidence: 56%

“…Hurley et al (1988) investigated results obtained by nonlaboratory personnel and found that physicians performed the test worst of all. However, it can also be run by nonlaboratory personnel.…”

Section: Discussionmentioning

confidence: 99%

“…The AccuLevel test assay was first developed for theophylline by Zuk et al (1985), who reported that the results correlated well with those obtained by established methods. Since then, a high degree of accuracy, convenience, potential cost savings, and time efficacy of the rapid theophylline assay have been documented (Vaughan et al, 1986;Hurley et al, 1988;Nguyen et al, 1988;Shier et al, 1988;Milavetz et al, 1989). The AccuLevel test has become available for PB, PHT, and CBZ and several reports (Cramer et al, 1986;Opheim et al, 1987;Oles et al, 1989;Wannamaker et al, 1989;Cochran et al, 1990) have obtained very good correlation with different conventional methods, and a good within-run and between-run precision.…”

Section: Discussionmentioning

confidence: 99%

“…However, it can also be run by nonlaboratory personnel. Hurley et al (1988) investigated results obtained by nonlaboratory personnel and found that physicians performed the test worst of all. However, these physicians did not attend a demonstration before using the assay and made only a few tests each.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of AccuLevel and TDx: Evaluation of On‐Site Monitoring of Antiepileptic Drugs

1992

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Therapeutic drug monitoring, an important aid in antiepileptic drug (AED) therapy, has a lag time before results are obtained from clinical laboratories. The AccuLevel test is an enzyme immunochromatographic method for quantitative measurement of AEDs including phenobarbital (PB), phenytoin (PHT), and carbamazepine (CBZ), with results available within 20 min. A comparison between AccuLevel and TDx, (fluorescence polarization immunoassay) was conducted in 233 paired blood samples from patients with AED therapy, including 12 Eskimo children receiving treatment in Greenland. Forty-five blood samples were analyzed for PB, 80 for PHT, and 108 for CBZ. Linear regression analysis showed good agreement between the two methods (r = 0.951, 0.958, and 0.945, respectively). The test is easy to perform, but care must be taken to follow the correct procedure, or inaccuracies will result. That happened in some of our results. A reduction in lag time, using on-site drug monitoring, was demonstrated. The AccuLevel is a rapid, accurate, and convenient method for use in AED monitoring.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%