Evaluation of a quantitative fetal fibronectin test for spontaneous preterm birth in symptomatic women

Abbott, D; Radford, Samara; Seed, Paul; Tribe, Rachel M.; Shennan, Andrew

doi:10.1016/j.ajog.2012.10.890

Cited by 108 publications

(116 citation statements)

References 12 publications

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“…We found a uniquely high proportion of women with qfFN concentration 500 ng/ml (15%), compared with other studies of qfFN where concentrations 500 ng/ml (1-5%) [10,11] or even 300 ng/ml (10%) [12] are usually rare.…”

Section: Commentcontrasting

confidence: 69%

“…For example, <2% (3/170) of those with qfFN concentrations <10 ng/ml delivered within 14 days in a group of women with a closed cervix (<2cm dilated) and symptomatic for threatened preterm labour [10], similar to our BFM cohort (0/11). In symptomatic women with fFN concentration 500 ng/ml and a closed cervix, risk of sPTB within 14 days was 46% (6/13) [10], compared to 67% (6/9) of women in our cohort with BFM.…”

Section: Commentsupporting

confidence: 62%

“…Women were enrolled in this sub-analysis at the time they had BFM noted at speculum (any degree of cervical dilatation), if they were between 18 and 32 weeks of gestation, were not contracting, and underwent both quantitative (Hologic Rapid fFN 10Q) and qualitative (single-threshold Hologic Rapid fFN TLi IQ ) fFN concentration measurements. fFN testing was M a n u s c r i p t 6 performed prior to ultrasound scan or digital examination using previously described methods, in line with the manufacturer's guidelines [10]. Briefly, during speculum examination, a swab was inserted into the posterior fornix and rotated for 10 seconds until saturated, avoiding the cervix and fetal membranes.…”

Section: Methodsmentioning

confidence: 99%

“…Our group has previously demonstrated the predictive value of quantitative fFN measurement in women presenting with symptoms of preterm labour, with added risk discrimination over and above the traditional qualitative test [10], as well as M a n u s c r i p t 11 in asymptomatic women at high risk of preterm birth [11]. However, women with bulging fetal membranes were excluded from those analyses.…”

Section: Commentmentioning

confidence: 99%

“…Prior to preterm birth, disturbance of the integrity of the maternal-fetal interface, particularly the partial separation of the decidua from the fetal membranes, is believed to result in release of fFN into the CVF fluid. More recently, enhanced prediction has been demonstrated using a quantitative bedside test (qfFN, Hologic 10Q system) which provides additional incremental thresholds to define variable risk [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Quantitative fetal fibronectin predicts preterm birth in women with bulging fetal membranes

Fiorini

Isted

Hezelgrave

et al. 2016

European Journal of Obstetrics & Gynecology and Reproductiv

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Please cite this article as: FIORINI F, ISTED A, HEZELGRAVE NL, SHENNAN AH, Quantitative fetal fibronectin predicts preterm birth in women with bulging fetal membranes, European Journal of Obstetrics and Gynecology and Reproductive Biology (2016), http://dx.doi.org/10. 1016/j.ejogrb.2016.05.046 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. CONCLUSION:Quantitative fFN has a role in predicting spontaneous preterm birth even in women with bulging fetal membranes, suggesting that fFN leakage could potentially be an active process. This may aid the clinical management of this high-risk group in the future.

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Section: Commentcontrasting

confidence: 69%

Section: Commentsupporting

confidence: 62%

Section: Methodsmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantitative fetal fibronectin predicts preterm birth in women with bulging fetal membranes

Fiorini

Isted

Hezelgrave

et al. 2016

European Journal of Obstetrics & Gynecology and Reproductiv

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Utility of cervical length and quantitative fetal fibronectin for predicting spontaneous preterm delivery among symptomatic nulliparous women

Kyozuka

Murata

Sato

et al. 2019

Intl J Gynecology & Obste

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Objective To validate the utility of fetal fibronectin (fFN) and cervical length (CL) in predicting preterm delivery among symptomatic nulliparous women. Methods A retrospective cohort study of nulliparous women who presented with uterine contractions, abdominal pain, or cervical change at 21–34 gestational weeks at Fukushima Medical University Hospital, Japan, between 2008 and 2017. fFN (categorized as <50 ng/dL, 50–199 ng/dL, >200 ng/dL) and CL (≥15 mm or <15 mm) were evaluated simultaneously. Adjusted odds ratios (aORs) and confidence intervals (CIs) for preterm delivery before 37 or 34 weeks, and delivery within 28 or 14 days were calculated (references: fFN, <50 ng/dL; CL, ≥15 mm). Result Among 285 women who met the study criteria, CL less than 15 mm was a risk factor for preterm delivery before 37 (aOR, 4.1; 95% CI, 1.1–6.7) and 34 (aOR, 6.8; 95% CI, 2.3–20.2) weeks. fFN of 200 ng/dL or higher was a risk factor for delivery within 28 (aOR, 19.8; 95% CI, 4.3–90.2) and 14 (aOR, 10.8; 95% CI, 1.7–67.6) days. Conclusion Among symptomatic nulliparous women, short CL was found to be a risk factor for preterm delivery and higher fFN levels were related to short gestational latency.

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Development and validation of a tool incorporating cervical length and quantitative fetal fibronectin to predict spontaneous preterm birth in asymptomatic high‐risk women

Kuhrt

Smout

Hezelgrave

et al. 2016

Ultrasound in Obstet & Gyne

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Evaluation of a quantitative fetal fibronectin test for spontaneous preterm birth in symptomatic women

Cited by 108 publications

References 12 publications

Quantitative fetal fibronectin predicts preterm birth in women with bulging fetal membranes

Quantitative fetal fibronectin predicts preterm birth in women with bulging fetal membranes

Utility of cervical length and quantitative fetal fibronectin for predicting spontaneous preterm delivery among symptomatic nulliparous women

Development and validation of a tool incorporating cervical length and quantitative fetal fibronectin to predict spontaneous preterm birth in asymptomatic high‐risk women

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