Evaluation of a protocol combining applications of Ophytrium-based shampoo and mousse in dogs with sensitive, itchy and irritated skin

Abstract

Topical formulations are key when managing skin conditions as they bring ingredients directly to the target organ. The objective of the study was to evaluate the effect of a protocol combining applications of Ophytrium-based shampoo and mousse (DOUXO® S3 CALM) in atopic dogs presenting with a skin flare. Thirty-four atopic dogs were included in the analysis of this prospective, multicentric European and US field study. Dogs received a shampoo application on D0 then mousse applications every 48–72 hours for three weeks. CADESI-04 scores were assessed by a dermatologist and pruritus by the owners (Pruritus Visual Analogue Scale score (PVAS)) on a weekly basis. On D21, veterinarian and pet owner evaluations were collected through questionnaires. Mean CADESI-04 score decreased significantly from 24.2 on D0 to 11.9 on D21 (49.4% mean improvement, P < 0.001 at all timepoints), and 61.8% of dogs achieved a ≥ 50% decrease of their CADESI-04 score on D21. Mean PVAS scores also decreased significantly between D0 and D21 (30.8% mean improvement, P < 0.001 at all timepoints) and 44.1% of the dogs showed a ≥ 50% PVAS decrease on D21. Veterinarians considered the improvement as satisfactory, good or excellent in 66.7% of cases. Pet owners were satisfied with the performance of the protocol in 72.7% of cases. In conclusion, the protocol combining applications of Ophytrium-based shampoo and mousse resulted in a quick and significant improvement in both skin health and pruritus in atopic dogs presenting with a skin flare with a high level of pet owner satisfaction.

Preliminary evaluation of a commercial shampoo and fine bubble bathing in the treatment of canine atopic dermatitis: A single‐blinded, randomised, controlled study

“…Figure 2 presents the mean ± SD (range) of CADESI-04 and PVAS scores at D0 and D28. In the FB group, the mean ± SD (range) of CADESI score decreased significantly from 16.0 ± 3.8 (1-35) at D0 to 9.4 ± 1.8 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) at D28 (paired Student's t-test, p < 0.05). However, in the shampoo group, the mean CADESI score decreased from 24.8 ± 7.2 (6-62) to 19.3 ± 6.3 (7-50), yet the difference was not significant compared to D0 (p = 0.10).…”

“…2 Treatment guidelines mention only two specific shampoo products: Allermyl (Virbac) and DOUXO Calm (Ceva Sante Animale). 3,4 Nondrug shampoos containing phytosphingosine or ophytrium-based shampoos have shown positive results in clinical evaluations. 4,5 Therefore, there is a need to explore new bathing methods for cAD treatment and their efficacy and impact on skin barrier function parameters.…”

“…3,4 Nondrug shampoos containing phytosphingosine or ophytrium-based shampoos have shown positive results in clinical evaluations. 4,5 Therefore, there is a need to explore new bathing methods for cAD treatment and their efficacy and impact on skin barrier function parameters. Loflath et al found that the use of ascending bubbles in a whirlpool can effectively lift the hairs, resulting in a more thorough cleansing of the skin surface by removing or diluting dirt, debris and inflammatory mediators.…”