Background-Minute ventilation sensors of cardiac pacemakers measure ventilation by means of transthoracic impedance changes between the pacemaker case and the electrode tip. We investigated whether this technique might detect sleep-related breathing disorders. Methods and Results-In 22 patients, analog waveforms of the transthoracic impedance signal measured by the pacemaker minute ventilation sensor over the course of a night were visualized, scored for apnea/hypopnea events, and compared with simultaneous polysomnography. Analysis of transthoracic impedance signals correctly identified the presence or absence of moderate to severe sleep apnea (apnea/hypopnea index, AHI Ͼ20 h Ϫ1 ) in all patients (receiver operating characteristics, ROCϭ1.0). The ROC for AHI scores of Ն5 h Ϫ1 and Ն10 h Ϫ1 showed an area under the curve of 0.95, PϽ0.005, and 0.97, PϽ0.0001, respectively. Accuracy over time assessed by comparing events per 5-minute epochs was high (Cronbach ␣ reliability coefficient, 0.85; intraclass correlation, 0.73). Event-by-event comparison within Ϯ15 seconds revealed agreement in 81% (, 0.77; PϽ0.001). Conclusions-Detection of apnea/hypopnea events by pacemaker minute ventilation sensors is feasible and accurate compared with laboratory polysomnography. This technique might be useful to screen and monitor sleep-related breathing disorders in pacemaker patients.