Evaluation of a Porcine Dermal Collagen (Permacol) Implant for Abdominal Wall Reconstruction in a Pediatric Multitrauma Patient

Melnik, Idit; Mnouskin, Y.; Kurzbart, E.; Yoffe, Boris

doi:10.1155/2014/585723

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…Biological prosthesis seems to have long-term durability with no incisional hernia on short and medium-term follow-up [123–127] (EL 4). The three articles selected assert that Permacol was effective for the reconstruction of the abdominal wall defect in particular cases: multi-trauma, conjoined twin, and in assisting abdominal wall closure of pediatric renal transplant recipient [124, 128, 129] (EL 4).…”

Section: Resultsmentioning

confidence: 99%

“Complex abdominal wall” management: evidence-based guidelines of the Italian Consensus Conference

Piccoli

Agresta²,

Attinà³

et al. 2018

Updates Surg

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To date, there is no shared consensus on a definition of a complex abdominal wall in elective surgery and in the emergency, on indications, technical details, complications, and follow-up. The purpose of the conference was to lay the foundations for a homogeneous approach to the complex abdominal wall with the primary intent being to attain the following objectives: (1) to develop evidence-based recommendations to define “complex abdominal wall”; (2) indications in emergency and in elective cases; (3) management of “complex abdominal wall”; (4) techniques for temporary abdominal closure. The decompressive laparostomy should be considered in a case of abdominal compartment syndrome in patients with critical conditions or after the failure of a medical treatment or less invasive methods. In the second one, beyond different mechanism, patients with surgical emergency diseases might reach the same pathophysiological end point of trauma patients where a preventive “open abdomen” might be indicated (a temporary abdominal closure: in the case of a non-infected field, the Wittmann patch and the NPWT had the best outcome followed by meshes; in the case of an infected field, NPWT techniques seem to be the preferred). The second priority is to create optimal both general as local conditions for healing: the right antimicrobial management, feeding—preferably by the enteral route—and managing correctly the open abdomen wall. The use of a mesh appears to be—if and when possible—the gold standard. There is a lot of enthusiasm about biological meshes. But the actual evidence supports their use only in contaminated or potentially contaminated fields but above all, to reduce the higher rate of recurrences, the wall anatomy and function should be restored in the midline, with or without component separation technique. On the other site has not to be neglected that the use of monofilament and macroporous non-absorbable meshes, in extraperitoneal position, in the setting of the complex abdomen with contamination, seems to have a cost effective role too. The idea of this consensus conference was mainly to try to bring order in the so copious, but not always so “evident” literature utilizing and exchanging the expertise of different specialists.

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Section: Resultsmentioning

confidence: 99%

“Complex abdominal wall” management: evidence-based guidelines of the Italian Consensus Conference

Piccoli

Agresta²,

Attinà³

et al. 2018

Updates Surg

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“…Mitchell et al reported no recurrences in patients treated with Permacol comparatively with 28% recurrence rate in those repaired with Gore-Tex in a case series of 37 neonates who underwent a patch repair of congenital diaphragmatic hernia [ 26 ]. Moreover, there is a case report with the application of Permacol for a traumatic abdominal wall repair in an 8-year-old boy with a favorable outcome [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Repair of Postoperative Abdominal Hernia in a Child with Congenital Omphalocele Using Porcine Dermal Matrix

Lambropoulos

Mylona

Mouravas

et al. 2016

Case Reports in Medicine

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Introduction. Incisional hernias are a common complication appearing after abdominal wall defects reconstruction, with omphalocele and gastroschisis being the most common etiologies in children. Abdominal closure of these defects represents a real challenge for pediatric surgeons with many surgical techniques and various prosthetic materials being used for this purpose. Case Report. We present a case of repair of a postoperative ventral hernia occurring after congenital omphalocele reconstruction in a three-and-a-half-year-old child using an acellular, sterile, porcine dermal mesh. Conclusion. Non-cross-linked acellular porcine dermal matrix is an appropriate mesh used for the reconstruction of abdominal wall defects and their postoperative complications like large ventral hernias with success and preventing their recurrence.

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“…Biological prosthesis seems to have long term durability with no incisional hernia on short and medium term follow-up [5] , [15] , [16] , [17] , [18] . 3 articles selected in our meta-analysis assert that Permacol was effective for the reconstruction of the abdominal wall defect in particular cases: multitrauma, conjoined twin, and in assisting abdominal wall closure of pediatric renal transplant recipient [5] , [6] , [7] . Also in the treatment of giant omphalocele biologic mesh was applied as a primary abdominal fascia substitute with good results, no fascial dehiscence or infections were reported [19] , [20] , [21] , [22] , [23] , [24] .…”

Section: Discussionmentioning

confidence: 99%

“…Research in recent years has developed biological dermal scaffolds made from a sheet of acellular matrix that can provide the desired support and reduce the occurrence of complications from non-absorbable implant (Permacol, Alloderm, Surgisis). Since 2001 Permacol™ Biological Implant has been successfully used in some pediatric and neonatal surgical cases, in particular to repair abdominal wall defects and congenital diaphragmatic hernia [4] , [5] , [6] , [7] . It is a sterile acellular sheet derived from porcine dermal collagen, indicated for reconstruction, recontouring and reformation of human soft connective tissue particularly where loss of dermis has occurred, and as a supporting tissue in surgical procedures such as abdominal wall hernias and defects.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and properties of the biological prosthesis Permacol™ in pediatric surgery: A large single center experience

Filisetti

Costanzo

Marinoni

et al. 2016

Annals of Medicine &Amp; Surgery

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IntroductionThe use of prosthetic patches of non-absorbable materials represents a valid tool in the treatment of abdominal wall and diaphragmatic defects in pediatric age. In recent years research has developed biological dermal scaffolds made from a sheet of acellular matrix that can provide the desired support and reduce the occurrence of complications from non-absorbable implant. We present our experience and a systematic review to evaluate the use of biologic prosthesis for abdominal wall closure in pediatric patients.MethodsThe study from January 2009 to January 2015 involved 20 patients treated with Permacol™ implant. We observed postoperative complications only in patients treated for abdominal wall closure, which is the major indication for the use of Permacol™. We conducted a systematic review and meta-analysis (according to PRISMA) on PubMed/Medline, Scopus and EMBASE regarding the use of biological prosthesis in pediatric population considering the incidence of complications as the primary outcome.Results3/20 patients experienced complications: 2 patients with skin necrosis healed conservatively and 1 of them developed laparocele. Thus only 1 patient with incisional hernia had significant surgery complication. In patients who were permanently implanted with Permacol™ it has not determined adverse reactions with optimal functional outcome.ConclusionsIn accordance with the few data (case reports and case series) reported in literature about pediatric patients, our experience in different pathologies and applications has shown the effectiveness of Permacol™, in particular for the non-occurrence of infections, that often affect the use of prosthesis.

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Evaluation of a Porcine Dermal Collagen (Permacol) Implant for Abdominal Wall Reconstruction in a Pediatric Multitrauma Patient

Cited by 6 publications

References 20 publications

“Complex abdominal wall” management: evidence-based guidelines of the Italian Consensus Conference

“Complex abdominal wall” management: evidence-based guidelines of the Italian Consensus Conference

Repair of Postoperative Abdominal Hernia in a Child with Congenital Omphalocele Using Porcine Dermal Matrix

Effectiveness and properties of the biological prosthesis Permacol™ in pediatric surgery: A large single center experience

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