Evaluation of a novel index by tissue Doppler imaging in patients with advanced heart failure: relation to functional class and prognosis

Abstract

The EAS index, which reflects systolic and diastolic performances, is a highly effective means of differentiating between patients with functional class I-II and those with III-IV. The index also correlates with cardiac mortality and hospitalisation for worsening heart failure, thus providing additional value to conventional echocardiographic measures.

Additional Prognostic Value of EAS index in predicting the occurrence of rehospitalizations in chronic heart failure: data from the Daunia Heart Failure Registry

“…In a prior study, Lee et al . demonstrated that EAS index correlates with NYHA class and may identify subjects with HF at risk for mortality and hospitalization for HF . In a large prospective study, EAS index was an independent predictor of death in the general population even in the subgroup with normal conventional echocardiography .…”

Assessment of no-reflow phenomenon by myocardial blush grade and pulsed wave tissue doppler imaging in patients with acute coronary syndrome

“…[19] Recently, in patients with significant LV dysfunction, EAS index has been considered as an independent predictor of NYHA functional class, and it has been also associated with cardiac mortality and hospitalization for heart failure. [20]…”

The Effects of Prolonged Acute Hypobaric Hypoxia on Novel Measures of Biventricular Performance

“…The EAS index is a new, yet increasingly, validated marker of combined LV systolic and diastolic performance . Its use was based on previous reports of the interdependence of myocardial velocities and the assumption that standardizing the E′ wave for the prior S′ wave would be a better measure of LV function than the E′/A′ ratios alone.…”

“…The E′/(A′×S′) (EAS) index is a recently described and novel marker of global cardiac function using PWTDI . Its premise is based on the linked responses of LV systolic and diastolic function.…”

“…Previous work has shown that a positive correlation between mitral annular peak systolic S′ velocity and early diastolic E′ velocities (as systolic performance is influenced by diastolic performance) and negative correlation between E′ velocity and late diastolic filling A′ velocity (related to atrial contraction) . Hence, combing E′ and its relationship to A′ and S′ in a single measure (E′/[A′x S′]) allows for a collective measure of systolic and diastolic function . A high EAS index is indicative of increased preload with systolic dysfunction, diastolic dysfunction, or both and has been linked to increasing brain natriuretic peptide (BNP) levels, even in patients without overt heart failure …”