Evaluation of a Nondepleted Plasma Multiprotein-Based Model for Discriminating Psychiatric Disorders Using Multiple Reaction Monitoring-Mass Spectrometry: Proof-of-Concept Study
Dongyoon Shin,
Jihyeon Lee,
Yeongshin Kim
et al.
Abstract:Psychiatric
evaluation relies on subjective symptoms and behavioral
observation, which sometimes leads to misdiagnosis. Despite previous
efforts to utilize plasma proteins as objective markers, the depletion
method is time-consuming. Therefore, this study aimed to enhance previous
quantification methods and construct objective discriminative models
for major psychiatric disorders using nondepleted plasma. Multiple
reaction monitoring-mass spectrometry (MRM-MS) assays for quantifying
453 peptides in nondepleted… Show more
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