Evaluation of a new system for self blood glucose monitoring

Clarke, William L.; Becker, Dorothy J.; Cox, Daniel J.; Santiago, Julio V.; White, Neil H.; Betschart, Jean; K, Eckenrode; Levandoski, Lucy A.; Prusinski, Elizabeth A.; Simineiro, Linda M.; Snyder, Andrea; Tideman, Ann M.; Yaeger, Terri

doi:10.1016/s0168-8227(88)80020-2

Cited by 40 publications

(18 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first one is inconvenience and the required compliance by patients, while the second is that this is not a continuous monitoring method. Despite intensive efforts [1][2][3][4][5][6][7][8][9][10][11], no method is currently available for the continuous non-invasive monitoring of blood glucose.…”

Section: Introductionmentioning

confidence: 99%

A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring

Badugu

Lakowicz

Geddes

2003

Journal of Fluorescence

105

View full text Add to dashboard Cite

We have developed a range of glucose sensing contact lenses, using a daily, disposable contact lens embedded with newly developed boronic acid containing fluorophores. Our findings show that our approach may be suitable for the continuous monitoring of tear glucose levels in the range 50-1000 µM, which typically track blood glucose levels, which are ≈5-10 fold higher. Our non-invasive approach may well offer an alternative solution to current invasive glucose monitoring techniques for diabetes, such as "finger pricking."

show abstract

Section: Introductionmentioning

confidence: 99%

A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring

Badugu

Lakowicz

Geddes

2003

Journal of Fluorescence

105

View full text Add to dashboard Cite

show abstract

“…Noninvasive measurements of blood glucose have been a long-standing research goal. To date, a wide variety of methods have been described in the literature, including near-infrared spectroscopy (3)(4)(5), optical rotation (6, 7), amperometric (8,9), colorimetric (10,11), and fluorescence detection (12)(13)(14)(15)(16). Despite some promising results, these methods show limitations.…”

mentioning

confidence: 99%

Evaluation of Two Synthetic Glucose Probes for Fluorescence-Lifetime-Based Sensing

DiCesare

Lakowicz

2001

Analytical Biochemistry

View full text Add to dashboard Cite

We evaluated two anthracene derivatives with covalently attached boronic acid groups for fluorescence-lifetime-based sensing of glucose. These anthracene derivatives also contained alkyl amino groups, which quenched the anthracene emission by photo-induced electron transfer. Both anthracene derivatives displayed increased intensities and lifetime in the presence of glucose, as seen from the frequency-domain measurements. A fluorescence lifetime change from 9.8 to 12.4 and 5.7 to 11.8 ns is observed, after the addition of glucose, for the anthracene substituted with one and two boronic acid groups, respectively. This results in a change in the phase angle up to 15 degrees and 30 degrees and in the modulation up to 12 and 25% at 30 MHz for these compounds, respectively. Titration curves in the presence of BSA and micelles are also presented to show the potential interferences from biomolecules. Dissociation constants were evaluated for both compounds, and association with glucose was found to be reversible. Importantly, the apparent glucose binding constants are about 5- to 10-fold smaller with phase, modulation, or mean lifetime than with intensities measurements, shifting the glucose-sensitive range to physiological values. Combining these results and the use of a simple UV-LED as excitation source, the results show an interesting potential of these two compounds in the development of lifetime base devices using synthetic probes for glucose.

show abstract

“…To add this error, an approximate model was created using the data available. Specifically, 78% of the measurements are within 20% of the actual value, defining the A range on the Clarke Error Grid [25], and the correlation between actual and the approximated blood glucose values is around 0.88 [11]. In addition, maximum errors in the literature are no greater than 40% based on observation of the results presented.…”

Section: B Modeling Noise For the Cgms Sensormentioning

confidence: 77%

Integral-based filtering of continuous glucose sensor measurements for glycaemic control in critical care

Chase

Hann

Jackson

et al. 2006

Computer Methods and Programs in Biomedicine

View full text Add to dashboard Cite

Hyperglycaemia is prevalent in critical illness and increases the risk of further complications and mortality, while tight control can reduce mortality up to 43%.Adaptive control methods are capable of highly accurate, targeted blood glucose regulation using limited numbers of manual measurements due to patient discomfort and labour intensity. Therefore, the option to obtain greater data density using emerging continuous glucose sensing devices is attractive. However, the few such

show abstract

Evaluation of a new system for self blood glucose monitoring

Cited by 40 publications

References 5 publications

A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring

A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring

Evaluation of Two Synthetic Glucose Probes for Fluorescence-Lifetime-Based Sensing

Integral-based filtering of continuous glucose sensor measurements for glycaemic control in critical care

Contact Info

Product

Resources

About