Evaluation of a New Software Version of the RTVue Optical Coherence Tomograph for Image Segmentation and Detection of Glaucoma in High Myopia

Holló, Gábor; Shu-wei, Hsu; Naghizadeh, Farzaneh

doi:10.1097/ijg.0000000000000290

Cited by 6 publications

(6 citation statements)

References 22 publications

(36 reference statements)

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“…All subjects were examined with an RTVue-100 Fourier-domain OCT instrument (Optovue Inc., Fremont, CA, USA) using the scanning protocol “GCC” (ganglion cell complex). The FD-OCT system imaging was performed as described in previous studies [ 29 ]. Briefly, the macular GCC (mGCC) scanning protocol consisted of a 7 mm × 7 mm area, which measured the retinal thickness from the ILM to the IPL posterior boundary.…”

Section: Methodsmentioning

confidence: 99%

Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults

Yang

Zhou

et al. 2017

Journal of Ophthalmology

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Purpose To quantify macular vascular density using optical coherence tomography angiography (OCTA) and to investigate its relationship with retinal thickness in myopic eyes of young adults. Methods In this cross-sectional study, 268 myopic eyes without pathological changes were recruited and divided into three groups: mild myopia (n = 81), moderate myopia (n = 117), and high myopia (n = 70). Macular vascular density was quantified by OCTA and compared among three groups. Average retinal thickness, central subfield thickness, and macular ganglion cell complex (mGCC) thickness were also evaluated and compared. Correlations among these variables were analyzed. Results There was no statistical difference in superficial (62.3 ± 5.7% versus 62.7 ± 5.9% versus 63.8 ± 5.5%) and deep macular vascular densities (58.3 ± 9.6% versus 59.2 ± 9.3% versus 60.9 ± 7.9%) among mild-myopia, moderate-myopia, and high-myopia groups (both P > 0.05). Superficial and deep macular vascular densities both had correlations with mean arterial pressure. Furthermore, superficial macular vascular density was significantly correlated with mGCC thickness. Conclusions Varying degrees of myopia did not affect macular vascular density in young healthy adults. In addition, superficial macular vascular density, as an independent factor, was positively correlated with mGCC thickness.

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Section: Methodsmentioning

confidence: 99%

Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults

Yang

Zhou

et al. 2017

Journal of Ophthalmology

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“…There has been some research on improving the software to increase GCC segmentation; however, this did not significantly improve the softwareprovided classification for glaucoma with high myopia. 20 A previous study showed that the cp-RNFL led to false-positive high detection for glaucoma with high myopia. A more accurate diagnosis for HM-G could be made if a normative database in highly myopic eyes were created.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia

Zhang

Wen

Sun

2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Zhang Y, Wen W, Sun X. Comparison of several parameters in two optical coherence tomography systems for detecting glaucomatous defects in high myopia. Invest Ophthalmol Vis Sci. 2016;57:4910-4915. DOI:10.1167/iovs.16-19104 PURPOSE. To compare the diagnostic powers of parameters of the RTVue and Cirrus-HD optical coherence tomography (OCT) systems in detecting glaucoma in highly myopic eyes.METHODS. For this study, 28 glaucoma patients with high myopia (HM-G) and 28 high-myopia controls (HM-C) were enrolled. The circumpapillary retinal nerve fiber layer (cp-RNFL) and ganglion cell complex (GCC) parameters in the RTVue-OCT, and the ganglion cell-inner plexiform layer (GCIPL) and cp-RNFL parameters in the Cirrus HD-OCT, were obtained for each subject. The receiver operating characteristics curve (ROC) was used to assess the diagnostic ability of each parameter, and the areas under the curves (AUROCs) of those parameters were compared.RESULTS. In both OCTs, the macular parameters showed significantly higher diagnostic power than the cp-RNFL thickness. The minimum GCIPL (0.977), inferotemporal GCIPL (0.947), and vertical cup/disc (C/D) ratio (0.968) showed the best performances among all of the Cirrus HD-OCT parameters. The focal loss volume (FLV) (0.964), global loss volume (GLV) (0.899), and vertical C/D ratio (0.899) showed the best performances among all of the RTVue-OCT parameters. Among the parameters with high diagnostic ability in each protocol of the two OCTs, the superior sector of the cp-RNFL had significantly lower abilities than the FLV and the minimum of the GCIPL (P < 0.05) in detecting glaucoma in high myopia.CONCLUSIONS. The macular measurements had significantly better glaucoma detection abilities than the cpRNFL thickness in the high-myopia subjects in both RTVue-OCT and Cirrus HD-OCT, with no significant differences in the diagnostic ability between the two macular parameters.

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“…Recent software updates have reduced GCC segmentation errors in patients with macular degeneration, which should allow these patients to be evaluated for glaucoma with more confidence. 133 , 134 Posterior pole asymmetry analysis (PPAA) combines mapping of the posterior pole retinal thickness with asymmetry analysis between eyes and between hemispheres of each eye. 135 Posterior pole asymmetry analysis, although not presently having a built-in normative database, is highly reproducible and matches circumpapillary RNFL measurements in terms of diagnostic accuracy of early glaucoma.…”

Section: Diagnosis Of Glaucomamentioning

confidence: 99%

Clinical Utility of Optical Coherence Tomography in Glaucoma

Dong

Wollstein

Schuman

2016

Invest. Ophthalmol. Vis. Sci.

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Optical coherence tomography (OCT) has established itself as the dominant imaging modality in the management of glaucoma and retinal diseases, providing high-resolution visualization of ocular microstructures and objective quantification of tissue thickness and change. This article reviews the history of OCT imaging with a specific focus on glaucoma. We examine the clinical utility of OCT with respect to diagnosis and progression monitoring, with additional emphasis on advances in OCT technology that continue to facilitate glaucoma research and inform clinical management strategies.

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Evaluation of a New Software Version of the RTVue Optical Coherence Tomograph for Image Segmentation and Detection of Glaucoma in High Myopia

Abstract: Although GCC segmentation was improved with software version 6.12 compared with the current version in highly myopic eyes, this did not result in a significant change of the average RNFLT and GCC values, and did not significantly improve the software-provided classification for glaucoma.

Cited by 6 publications

References 22 publications

Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults

Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults

Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia

Clinical Utility of Optical Coherence Tomography in Glaucoma

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