Evaluation of a new point of care automated complete blood count (CBC) analyzer in various clinical settings

Rao, Lokinendi V.; Ekberg, Björn; Connor, Diane; Jakubiak, Felice; Vallaro, Guy M.; Snyder, Michael L.

doi:10.1016/j.cca.2007.12.006

Cited by 44 publications

(27 citation statements)

References 5 publications

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“…The HemoScreen imprecision values were found to be within the allowable total errors as defined by CLIA guidelines14 and are acceptable in accordance with desirable specifications for imprecision as determined by different models 15 16. The observed CV percentages are also equivalent to those previously reported for several FDA-cleared haematology POC analysers 17 18. The HemoScreen provides CBC results, which are comparable with the reference method with r values of 0.92 or greater.…”

Section: Discussionsupporting

confidence: 77%

The HemoScreen, a novel haematology analyser for the point of care

Ben-Yosef¹,

Marom

Hirshberg

et al. 2016

J Clin Pathol

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The HemoScreen employs innovative technologies of viscoelastic focusing and microfluidics within a disposable cartridge for an image-based blood cell analysis. By providing accurate and repeatable CBC and five-part differential results within minutes and maintaining the simplicity of operation, the HemoScreen could have far-reaching implications for use at POC. Further extended evaluation is in progress.

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Section: Discussionsupporting

confidence: 77%

The HemoScreen, a novel haematology analyser for the point of care

Ben-Yosef¹,

Marom

Hirshberg

et al. 2016

J Clin Pathol

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show abstract

“…It measures a 3 part differential WBC, RBC and platelet counts with a single disposable cartridge. [7][8][9] All these devices have been CE marked (Europe) and 510k approved (US), which allows their use in the clinical environment by trained professionals. They are not, however, approved for 'self-testing' use by the patient.…”

mentioning

confidence: 99%

Integrated systems for rapid point of care (PoC) blood cell analysis

et al. 2011

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Counting the different subpopulations of cells in a fingerprick of human blood is important for a number of clinical point-of-care (PoC) applications. It is a challenge to demonstrate the integration of sample preparation and detection techniques in a single platform. In this paper we demonstrate a generic microfluidic platform that combines sample processing and characterisation and enumeration in a single, integrated system. Results of microfluidic 3-part differential leukocyte (granulocyte, lymphocyte and monocyte) counts, together with erythrocyte and thrombocyte (platelet) counts, in human blood are shown and corroborated with results from hospital clinical laboratory analysis.

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“…Optical detection was chosen for particle detection and characterization because of the range of inexpensive optical sources and detectors 22-24 and the ability to carry out a wide range of assays including fluorescence. While electrical impedance methods are attractive due to their small size and reduced system complexity 25-28 , impedance based methods are limited in assay menus for a generalized clinical measurement platform. To extend the simplicity of the inertial focusing chip, we sought to decrease the complexity and the size of the optical system by incorporating optical elements within the microfluidic chip that contains the flow cell.…”

Section: Discussionmentioning

confidence: 99%

Inertial focusing cytometer with integrated optics for particle characterization

et al. 2013

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Microfluidic inertial focusing has been shown as a simple and effective method to localize cells and particles within a flow cell for interrogation by an external optical system. To enable portable point of care optical cytometry, however, requires a reduction in the complexity of the large optical systems that are used in standard flow cytometers. Here, we present a new design that incorporates optical waveguides and focusing elements with an inertial focusing flow cell to make a compact robust cytometer capable of enumerating and discriminating beads, cells, and platelets.

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Evaluation of a new point of care automated complete blood count (CBC) analyzer in various clinical settings

Cited by 44 publications

References 5 publications

The HemoScreen, a novel haematology analyser for the point of care

The HemoScreen, a novel haematology analyser for the point of care

Integrated systems for rapid point of care (PoC) blood cell analysis

Inertial focusing cytometer with integrated optics for particle characterization

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