Evaluation of a New Noninvasive Glucose Monitoring Device by Means of Standardized Meal Experiments

Abstract

After appropriate individual calibration of the NI technology, both the NI and the invasive CoG components reliably tracked tissue and blood glucose values, respectively. This may enable patients with diabetes to monitor their glucose levels frequently, reliably, and most of all pain-free.

Device and Method for Noninvasive Glucose Assessment

“…The results of a recent study in patients with type 1 diabetes, type 2 diabetes, and healthy subjects, where a standardized meal experiment was used to evaluate the noninvasive CoG performance in comparison to several comparators and a standard reference method, are reported by Pfützner et al in the same journal. 31 Our goal was to develop a noninvasive device for an accurate prediction of capillary tissue glucose with a good and reliable performance as compared to common invasive methods. Initial clinical studies have already provided encouraging results, and more confirmatory studies are currently under way in different patient populations.…”

“…A clinical study was performed recently at the Pfützner Science & Health Institute, the study summary can be found in this journal. 31 All studies were performed in accordance with applicable legal and ethical standards. The respective ethical review boards approved the study protocols, and participants signed informed consent prior to any study procedure.…”

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

“…In order to counter these effects, multi-technology and multi-sensors can be implemented and tailored to design a non-invasive sensor that is most sensitive to glucose molecules and independent of the many factors that contribute to false readings [65,147,166,167,211]. Artificial intelligence and data analytics is necessary to analyze the data collected and to incorporate it into a prediction model to accurately quantify glucose levels [235].…”

“…Glucose reading is based on the analysis of six-dimensional signal (position [x, y], time [t], color [red green blue]) which correlates with blood glucose concentration. The performance of the sensor was investigated in [65,66] by conducting a study on 14 healthy subjects, six T1D patients and 16 T2D patients. Based on the consensus error grid, 100% of data were demonstrated to be in zone A (96.6%) and B (3.4%) [65].…”

Assessment of potential drug and substance interference on the performance of the CNOGA TensorTip blood glucose measuring device

“…In preparation of regular operations, the device needs a comprehensive calibration procedure with frequent comparator measurements between the NI readings and an incorporated regular invasive glucoseoxidase-based blood glucose meter module. In a previous clinical trial, the CoG device was shown to accurately track glucose changes in standardized meal experiment in healthy subjects and in people with type 1 and type 2 diabetes after a calibration period of one week [3].…”