Evaluation of a New Macrocyclic Antibiotic as a Chiral Selector for Use in Capillary Electrophoresis

Sharp, V. Scott; Risley, Donald S.; Mccarthy, S.; Huff, Bret E.; Strege, Mark A.

doi:10.1080/10826079708013660

Cited by 28 publications

(12 citation statements)

References 34 publications

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“…Thus, the positively charged selector moves to the cathode, clearing the detection window, and the analytes can be detected without interferences at the anodic side. Further macrocyclic antibiotics of the glycopeptide type investigated as chiral selectors are A 82846B [404], LY307599 [405], Actaplanin A [406], Avoparcin [407], Hepta-tyr [408] and A 35512B [409].…”

Section: Neutral CD Derivatives a Great Variety Of Neutral Derivativmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

225

135

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This review gives a survey of different chiral separation principles and their use in high-performance liquid chromatography (HPLC), gas chromatography (GC), supercritical fluid chromatography (SFC), thin-layer chromatography (TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC) highlighting new developments and innovative techniques. The mechanisms of the different separation principles are briefly discussed and some selected applications are shown.

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Section: Neutral CD Derivatives a Great Variety Of Neutral Derivativmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

225

135

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“…The pZ value was estimated to be around 9, reflecting its basic character. The macrocyclic antibiotic LY307599, which is a derivative of A82846B and only differing in an additional biphenyl moiety, was evaluated for the separation of flurbiprofen [300]. Optimum resolution within a reasonable migration time was achieved by varying several parameters such as buffer pH, selector concentration and methanol concentration.…”

Section: Macrocyclic Glycopeptide Antibioticsmentioning

confidence: 99%

Separation of chiral compounds by capillary electrophoresis

1998

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This review presents the different chiral selectors used in capillary electrophoresis (CE) for the separation of enantiomers. The use of charged cyclodextrins, crown ethers, polysaccharides, proteins, natural and synthetic micelles, macrocyclic antibiotics and ergot alkaloids is discussed in detail. Neutral native and derivatized cyclodextrins are not treated because several review articles have already been published on this topic. Recent developments like the application of two chiral selectors in the same background electrolyte are highlighted.

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“…LY307599, a derivative of A 82846B, which differs from the latter compound by an additional biphenyl moiety, was evaluated using flurbiprofen [121]. Actaplanin A [122] represents a further member of this family which also found application to the chiral separation of NSAIDs of the profen type.…”

Section: Macrocyclic Antibioticsmentioning

confidence: 99%

Recent progress in chiral separation principles in capillary electrophoresis

2000

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This review summarizes recent developments in the field of chiral separations by electromigration techniques including capillary zone electrophoresis (CZE), capillary gel electrophoresis (CGE), isotachophoresis (ITP), electrokinetic chromatography (EKC), and capillary electrochromatography (CEC). This overview focuses on the development of new chiral selectors and the introduction of new techniques rather than applications of already established selectors and methods. The mechanisms of the different chiral separation principles are discussed.

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Evaluation of a New Macrocyclic Antibiotic as a Chiral Selector for Use in Capillary Electrophoresis

Cited by 28 publications

References 34 publications

Chiral separation by chromatographic and electromigration techniques. A Review

Chiral separation by chromatographic and electromigration techniques. A Review

Separation of chiral compounds by capillary electrophoresis

Recent progress in chiral separation principles in capillary electrophoresis

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