Evaluation of a new hydrogel coating for drainage tubes

Pearce, R.Scott C.; West, Linda; Rodeheaver, George T.; Edlich, Richard F.

doi:10.1016/0002-9610(84)90351-9

Cited by 10 publications

(5 citation statements)

References 1 publication

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“…Among therapeutics, adsorbent coatings for blood perfusion,208–211 hemodialysis membranes,212–216 blood oxygenators,214 degradable drug delivery systems, medicated and soft contact lenses should be mentioned 217–221. Implants include intraocular lenses,222, 223 artificial corneas,224–228 coating for drainage tubes and stents,229–232 vitreous humor replacements,233 soft tissue substitutes/replacements,126, 234, 235 burn dressing,236–241 bone ingrowth sponges,242 plastic surgery,243–245 scleral buckling implants for retinal surgery 246–249. Finally, as pure TE products, temporal artificial skin substitutes, membranes used to prevent postoperation adhesion and to promote healing,250 HGs produced in vivo by using in situ photo‐polymerization,9, 10, 35, 37, 202, 262, 263, 275, 276, 279 HGs for cell encapsulation28, 29, 45, 52, 53, 203 and consequently corporal and extra‐corporal bioartificial or biohybrid organs (e.g., artificial pancreas, artificial liver)251–260 have been produced and investigated.…”

Section: Biomedical/tissue Engineering Applicationsmentioning

confidence: 99%

Identification of Muir–Torre syndrome among patients with sebaceous tumors and keratoacanthomas

Ponti

Losi

Gregorio³

et al. 2005

Cancer

134

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The three‐dimensional architecture of the right ventricular myocardium is a major determinant of function, but as yet no investigator‐independent methods have been used to characterize either the normal or hypertrophied state. We aimed to assess and compare, using diffusion tensor magnetic resonance imaging, the normal architecture with the arrangement induced by chronic hypertrophy. We randomized 20 female 5 kg piglets into pulmonary trunk banding (N = 16) and sham operation (N = 4). Right ventricular hypertrophy was assessed after 8 weeks. The excised and fixed hearts were subject to diffusion tensor imaging to determine myocyte helical angles, and the presence of any reproducible tracks formed by the aggregated myocytes. All banding animals developed significant right ventricular hypertrophy, albeit that no difference was observed in terms of helical angles or myocardial pathways between the banded animals and sham group animals. Helical angles varied from ∼70 degrees endocardially to −50 degrees epicardially. Very few tracks were circular, with helical angles approximating zero. Reproducible patterns of chains of aggregated myocytes were observed in all hearts, regardless of group. The architecture of the myocytes aggregated in the walls of the right ventricle is comparable to that found in the left ventricle in terms of endocardial and epicardial helical angles, however the right ventricle both in the normal and the hypertrophied state lacks the extensive zone of circular myocytes seen in the mid‐portion of the left ventricular walls. Without such beneficial architectural remodelling, the porcine right ventricle seems unsuited structurally to sustain a permanent increase in afterload. Anat Rec, 2009. © 2009 Wiley‐Liss, Inc.

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Section: Biomedical/tissue Engineering Applicationsmentioning

confidence: 99%

Identification of Muir–Torre syndrome among patients with sebaceous tumors and keratoacanthomas

Ponti

Losi

Gregorio³

et al. 2005

Cancer

134

View full text Add to dashboard Cite

show abstract

“…Among therapeutics, adsorbent coatings for blood perfusion, 208-211 hemodialysis membranes, [212][213][214][215][216] blood oxygenators, 214 degradable drug delivery systems, medicated and soft contact lenses should be mentioned. [217][218][219][220][221] Implants include intraocular lenses, 222,223 artificial corneas, [224][225][226][227][228] coating for drainage tubes and stents, [229][230][231][232] vitreous humor replacements, 233 soft tissue substitutes/replacements, 126,234,235 burn dressing, [236][237][238][239][240][241] bone ingrowth sponges, 242 plastic surgery, [243][244][245] scleral buckling implants for retinal surgery. [246][247][248][249] Finally, as pure TE products, temporal artificial skin substitutes, membranes used to prevent postoperation adhesion and to promote healing, 250 HGs produced in vivo by using in situ photopolymerization, 9,10,35,37,202,…”

Section: Biomedical/tissue Engineering Applicationsmentioning

confidence: 99%

Hydrogels for Tissue Engineering and Delivery of Tissue-Inducing Substances

Baroli

2007

Journal of Pharmaceutical Sciences

151

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“…This "water shield" impedes bacterial adherence 24 and is also more resistant of blood clot adherence compared to standard EVD catheters. 25 The hydrogel-coated catheters may also be soaked in antibiotic solution that may adhere to the catheter surface. While such hydrogel-coated EVD are commercially available, there have been no previous studies to assess their clinical effectiveness compared to standard EVD catheters.…”

Section: Anthony M Kaufmann Tara Lye Gary Redekop Angela Brevnermentioning

confidence: 99%

Infection Rates in Standard vs. Hydrogel Coated Ventricular Catheters

Kaufmann

Lye

Redekop

et al. 2004

Can. j. neurol. sci.

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Background:Infection related to external ventricular drain (EVD) use is a common neurosurgical complication. Modified catheters with a hydrophilic surface may impede bacterial adherence and thereby reduce catheter related cerebrospinal fluid (CSF) infection.Methods:A prospective randomized clinical trial compared the occurrence of CSF infection related to use of either standard silastic or hydrogel coated EVD catheters (Bioglide®, Medtronic). Enrolment was available to all adult neurosurgery patients undergoing placement of a first EVD, at three university centers. The catheters were presoaked in a low concentration of bacitracin solution for 5-10 minutes prior to insertion. Bacterial infection was defined by heavy growth in a single CSF sample or light / medium growth in two consecutive samples. A secondary analysis was also conducted for “probable” CSF infection, including patients started on antibiotics after light / medium growth in a single CSF sample. Statistical analyses included Kaplan-Meier survival curve estimates accompanied by Log Rank and Breslow tests.Results:There were 158 randomized patients available to assess for EVD related infection of CSF. The two study groups had similar clinical characteristics including average duration of EVD use (8±4 days). Definite CSF infection occurred in seven and probable infection in another six (8% total). Infection incidence rose steadily from day 2 (1%) to day 11 (11%). There was no difference of daily occurrence of EVD infection between the two catheter types.Conclusion:Infection remains a common hazard in the use of EVD, and we found no reduction of infection using the hydrogel-coated catheters when presoaked in low concentration bacitracin solution.

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Evaluation of a new hydrogel coating for drainage tubes

Cited by 10 publications

References 1 publication

Identification of Muir–Torre syndrome among patients with sebaceous tumors and keratoacanthomas

Identification of Muir–Torre syndrome among patients with sebaceous tumors and keratoacanthomas

Hydrogels for Tissue Engineering and Delivery of Tissue-Inducing Substances

Infection Rates in Standard vs. Hydrogel Coated Ventricular Catheters

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