Evaluation of a New Design of Antireflux-biodegradable Ureteral Stent in Animal Model

Soria, Federico; Morcillo, Esther; Serrano, Álvaro; Alba, A. Budía; Fernández, Inmaculada; Aparicio, Tomás Fernández; Sánchez-Margallo, Francisco M.

doi:10.1016/j.urology.2018.02.004

Cited by 40 publications

(30 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this setting, experimental data would help to test the function (particularly, resistance to retrograde pressure) and durability of the antireflux valve, potentially providing insights into further modifications. Animal models have been utilized to evaluate not only feasibility of drug‐eluting biliary SEMSs 72,73 and biodegradable biliary stents, 74,75 but also antireflux properties of ureteral stents 76–78 . However, there has been a lack of data on ARMSs from animal and phantom studies due to the limited access to those experimental systems.…”

Section: In Vitro Models For Preclinical Evaluation Of Antireflux Valvesmentioning

confidence: 99%

Antireflux metal stent for biliary obstruction: Any benefits?

Hamada

Nakai

Isayama

et al. 2020

Digestive Endoscopy

View full text Add to dashboard Cite

Endoscopic retrograde cholangiopancreatography with stent placement has been utilized as standard palliative management of distal malignant biliary obstruction (MBO). Compared to plastic stents, metal stents can provide longer‐term relief of symptoms. When a large‐bore metal stent is placed across the ampulla, patients are predisposed to the risk of cholangitis or stent dysfunction due to reflux of duodenal contents. To mitigate the risk of adverse events associated with the duodenobiliary reflux, efforts have been directed to development of antireflux metal stents (ARMSs). The antireflux property has been introduced through adding of an antireflux valve to the duodenal stent end. Evidence from clinical studies indicates that ARMSs may not only reduce the risk of ascending cholangitis during follow‐up but also prolong stent patency time. However, the results of clinical studies testing ARMSs are inconsistent owing to heterogeneous designs of antireflux valves and stent bodies. Metal stents are increasingly indicated for benign biliary strictures and MBO in the setting of neoadjuvant chemotherapy, and therefore, research is warranted to evaluate ARMSs for those indications. Given that endoscopic ultrasound (EUS)‐guided transmural biliary drainage has gained popularity, the optimal timing of placing an ARMS in relation to EUS‐guided and percutaneous drainage should be investigated. Development and evaluation of ARMSs require an integrative approach utilizing phantom and animal models, measurements of stent mechanical properties, and in vivo functional study after stent placement. In this review article, we summarize updated evidence on ARMSs for MBO and discuss issues that should be addressed in future studies.

show abstract

Section: In Vitro Models For Preclinical Evaluation Of Antireflux Valvesmentioning

confidence: 99%

Antireflux metal stent for biliary obstruction: Any benefits?

Hamada

Nakai

Isayama

et al. 2020

Digestive Endoscopy

View full text Add to dashboard Cite

show abstract

“…Other methods are biodegradable stents, stents with magnetic tip and stent with strings. [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] Novel biodegradable ureteral stents were manufactured using Uriprene to improve urine drainage, provide good biocompatibility and avoid traditional removal. 37 The issues with these stents included axial rigidity leading to difficult placement, non-uniform degradation and the biodegrading time of 10 weeks which was longer than typical indwelling stents.…”

Section: Variations In Stent Removalmentioning

confidence: 99%

“…However, studies by Barros et al and Soria et al have demonstrated degradation in a predictable and controlled fashion with no obstructive fragments. 37,39 Certain stents have strings attached to help removal and some have baskets to improve the passageway for small stones and stop bigger stones' migration through the ureter. 4,38 There are other stents made from biodegradable/bioabsorbable metal mesh and some have polymeric flap valves to reduce reflux.…”

Section: Variations In Stent Removalmentioning

confidence: 99%

See 1 more Smart Citation

<p>Strategies to Improve Patient Outcomes and QOL: Current Complications of the Design and Placements of Ureteric Stents</p>

Ramachandra

Mosayyebi²,

Carugo³

et al. 2020

RRU

View full text Add to dashboard Cite

Ureteric stents have played a vital role in relieving urinary obstruction in many urological conditions. Although they are extremely successful, stents have been associated with complications and reduced patients' health-related quality of life (HRQoL). There are many factors that may affect the quality and longevity of stents. In this review, we have highlighted the journey and innovation of ureteric stents through the modern day. A literature review was conducted to identify relevant articles over the last 20 years. There is a plethora of evidence with various indications for the use of ureteral stents and how they affect QoL. There is still ongoing research to develop the ideal stent with reduced encrustation, one that resists infection and is also comfortable for the patients. Stents made from metal alloys, polymers and biodegradable materials have unique properties in their own right but also have certain deficiencies. These have been discussed along with an overview of newly developed stents. Certain pharmacological adjuncts have also been highlighted that may be useful to improve patient's tolerance to stents. In summary, this paper describes the features of the different types of stents and the problems that are frequently encountered, including effect on patients' HRQoL and financial burden to healthcare providers.

show abstract

“…The use of stents often leads to adverse symptoms and the need of a second procedure to remove them. In an animal study[ 5 ] on pigs, biodegradable antireflux stents were used. These stents did not cause secondary vesicoureteral reflux and trigone irritation.…”

mentioning

confidence: 99%

Round up

Kumar

2018

Indian J Urol

View full text Add to dashboard Cite

Evaluation of a New Design of Antireflux-biodegradable Ureteral Stent in Animal Model

Cited by 40 publications

References 24 publications

Antireflux metal stent for biliary obstruction: Any benefits?

Antireflux metal stent for biliary obstruction: Any benefits?

<p>Strategies to Improve Patient Outcomes and QOL: Current Complications of the Design and Placements of Ureteric Stents</p>

Round up

Contact Info

Product

Resources

About