Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non‐palpable breast lesions

Klein, Rebecca L.; Mook, Julie A.; Euhus, David M.; Rao, Roshni; Wynn, Ralph; Eastman, Amy B.; Leitch, A. Marilyn

doi:10.1002/jso.22146

Cited by 55 publications

(44 citation statements)

References 15 publications

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“…Consequently, if the marker is not deployed exactly within the biopsy cavity, the self-expanding nature of the markers could result in extrusion along the biopsy tract. In fact, in a retrospective review by Klein et al, 18 breast surgeons who were attempting to perform excisional biopsies using intraoperative ultrasound alone (without a separate pre-operative localization procedure) reported extrusion of the HydroMARK® in 14 of 31 cases when the biopsy tract was traversed during surgery.…”

Section: Discussionmentioning

confidence: 99%

A prospective comparative study to evaluate the displacement of four commercially available breast biopsy markers

Pinkney

Mychajlowycz

Shah

2016

BJR

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Section: Discussionmentioning

confidence: 99%

A prospective comparative study to evaluate the displacement of four commercially available breast biopsy markers

Pinkney

Mychajlowycz

Shah

2016

BJR

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“…Ultrasound-guided lumpectomy directed at the hematoma (HUG)[3] or a breast marker[4] avoids preoperative localization, but requires surgeon training and a clearly visible hematoma or marker. Radio-guided occult lesion localization (ROLL) involves injecting 99 technetium into the lesion the day before, or morning of, surgery.…”

Section: Introductionmentioning

confidence: 99%

Radioactive Seed Localization Compared to Wire Localization in Breast-Conserving Surgery: Initial 6-Month Experience

et al. 2013

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Introduction Wire localization (WL) of non-palpable breast cancers on the day of surgery is uncomfortable for patients and impacts OR efficiency. Radioactive seed localization (RSL) before the day of surgery avoids these disadvantages. In this study we compare outcomes of our initial 6-month experience with RSL to those with WL in the preceding 6 months. Methods Lumpectomies for invasive or intraductal cancers localized with a single 125iodine seed (January-June 2012) were compared to those using 1 wire (July-December 2011). Surgeons and radiologists did not change. Positive and close margins were defined as tumor on ink and tumor ≤1mm from ink, respectively. Demographic and clinical characteristics and outcomes were compared between RSL and WL patients. Results There were 431 RSL and 256 WL lumpectomies performed. Clinicopathologic characteristics did not differ between groups. Most seeds (90%) were placed before the day of surgery. Positive margins were present in 7.7% of RSL versus 5.5% of WL patients, and 16.9% of RSL versus 19.9% of WL had close margins (p=0.38). The median operative time was longer for lumpectomy and sentinel lymph node biopsy (SLNB) in the RSL group (55 versus 48 minutes, p<0.0001). There was no significant difference in the volume of tissue excised between groups. Conclusions In the first 6 months of RSL, operative scheduling was simplified, while rates of positive and close margins were similar to those seen after many years of experience with WL. Operative time was slightly longer for RSL lumpectomy and SLNB; we anticipate this will decrease with experience.

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“…The markers included the SenoMarkUltraCor MRI (SenoRx, Irvine, California), Gel Mark UltraCor (SenoRx), HydroMARK (Biopsy Sciences, Clearwater, Florida), SecurMark (Hologic, Bedford, Massachusetts), and UltraClip Enhanced Coil (C. R. Bard, Inc, Murray Hill, New Jersey). 3,[6][7][8][9] The final biopsy markers were selected based on which markers were currently in stock at our institution and, after contacting several manufacturers, those companies willing to donate markers for the purposes of the project. The biopsy markers were limited to five given the time necessary to obtain cohorts of five patients with the same biopsy marker who were willing to participate in the clinical study.…”

Section: Methodsmentioning

confidence: 99%

“…Additional potential benefits include cost savings, a lower incidence of operating room scheduling conflicts, and more effective and cosmetically pleasing excisional procedures. [3][4][5] Regardless of whether the biopsy marker will be used for an ultrasound-guided localization procedure or lumpectomy using the IOUS technique, a highly sonographically visible marker is desired. The goal of this study was to compare the sonographic visibility of five commercially available breast biopsy site markers at the time of deployment, 6 weeks after marker placement, and 12 weeks after marker placement.…”

Section: Original Articlementioning

confidence: 99%

Prospective Comparative Study to Evaluate the Sonographic Visibility of Five Commercially Available Breast Biopsy Markers

Pinkney

Shah

2013

Journal of Diagnostic Medical Sonography

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The demand for highly sonographically visible breast biopsy markers is growing as an increasing number of physicians are using sonography for preoperative localization and single-step intraoperative ultrasound-guided excisional procedures. The objective of this study was to directly compare the sonographic visibility of five commercially available breast biopsy site markers. A single-site prospective comparative study was performed with 25 female participants, each assigned to receive one of five biopsy markers. Postdeployment, 6-week, and 12-week follow-up sonographic images were obtained and a survey was e-mailed to members of the Society of Breast Imaging asking them to grade marker visibility on a 1-to 5-point Likert-type scale. At the time of deployment, the SecurMark (Hologic, Bedford, Massachusetts) was rated with the highest sonographic visibility. At both 6 and 12 weeks after deployment, the HydroMARK (Biopsy Sciences, Clearwater, Florida) was found to be the most visible by sonography. The results can be used by physicians who require highly sonographically visible breast biopsy markers for ultrasound-guided interventional procedures. Further research is needed as biopsy marker manufacturers continue to refine their products.

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Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non‐palpable breast lesions

Abstract: While intraoperative sonographic visibility was excellent, a large number of excisions were associated with extrusion of the marker. Modifications are needed to improve acceptability of this marker for intra-operative localization independent of pre-operative wire or seed localization.

Cited by 55 publications

References 15 publications

A prospective comparative study to evaluate the displacement of four commercially available breast biopsy markers

A prospective comparative study to evaluate the displacement of four commercially available breast biopsy markers

Radioactive Seed Localization Compared to Wire Localization in Breast-Conserving Surgery: Initial 6-Month Experience

Prospective Comparative Study to Evaluate the Sonographic Visibility of Five Commercially Available Breast Biopsy Markers

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