Evaluation of a fluorescence feedback system for guidance of laser angioplasty

Abstract

By discriminating atherosclerotic from normal tissue and by confirming catheter-tissue contact and saline hemodilution, fluorescence feedback should minimize irradiation of normal tissue and/or blood and enhance the safety and efficacy of laser angioplasty.

Correlation between near‐infrared Raman spectroscopy and the histopathological analysis of atherosclerosis in human coronary arteries

“…Initially the research was focused on autofluorescence emission for disease characterization [6][7][8] and for using it as a guidance for laser angioplasty system [9,10]. But due to the poor biochemical information carried out by fluorescence spectrum, the use of near-infrared Raman spectroscopy (NIRS) for tissue classification has been gaining evidence [11][12][13].…”

Single-laser approach for fluorescence guidance of excimer laser angioplasty at 308 nm: Evaluation in vitro and during coronary angioplasty

“…Most data on arterial fluorescence have been accumulated using a low-power He-Cd laser (325 nm) for fluorescence excitation [5][6][7][8][9][10]. A doublelaser system consisting of a dye laser operating at 480 nm for ablation and a diagnostic He-Cd laser was used in humans with obstructive peripheral artery disease [11][12][13][14].…”

Comparison between laser-induced photoemissions and phototransmission of hard tissues using fibre-coupled Nd:YAG and Er3+-doped fibre lasers

“…8 The upper trace shows the first micropulses of an Er fibre laser macropulse detected by the InAs photodiode. The lower trace records the photoemission signal from a laserirradiated tooth enamel sample detected by the silicon photodiode [7] Discussion and conclusion Irradiation of tissues with UV [18] and visible [19,20] wavelengths has been extensively used to excite fluorescence emission in biological tissue for diagnostic purposes, but such fluorescence signals cannot be obtained at longer near-IR excitation wavelengths. However, the presence of a characteristic broad emission spectrum background following irradiation of hard tissue can be attributed to bremsstrahlung emission, together with discrete emission lines resulting from the presence of neutral and ionic species, from the bulk tissue and ejected plume.…”