Evaluation of a Dry Coating Technology as a Substitute for Roller Compaction for Dry Agglomeration Applications in the Pharmaceutical Industry

Characterization of surface properties of dry-coated anhydrous borax powders

“…Ordered mixing occurs because of physico-chemical surface interactions between particles of highly different sizes. This principle explains that fine and cohesive particles, when properly dispersed in the powder blend; tend to stick to the surface of coarse particles, mainly due to van der Waals interactions [18,19]. When the ratio of diameters is high enough, the adhesive forces associated with surface attraction become greater than the repulsive forces applied by the environment on the particles, mainly associated with gravity and inertia.…”

“…When the ratio of diameters is high enough, the adhesive forces associated with surface attraction become greater than the repulsive forces applied by the environment on the particles, mainly associated with gravity and inertia. The resulting powder is then composed of similarly structured units where the fines are coated on the surface of the coarser particles [19]. The dry coating is achieved through mechanical forces (mechanical impact, shearing, etc.…”

“…The coating durability varies considerably depending on powders' properties and mainly the coating process used. Several systems have been developed for dry coating such as Mechanofusion, Hybridizer, and Cyclomix for applying a high level of mechanical forces, or Theta Composer and V-Blender for applying a small level of mechanical forces [14,17,19]. The coating systems where high levels of mechanical forces are applied [16], such as hybridizers and mechanofusion, generate local temperature rise [14] compared to other systems.…”