Evaluation of a Collagen/Hydroxylapatite Implant for Orbital Reconstructive Surgery

Calcium orthophosphate-based biocomposites and hybrid biomaterials

“…Biomimetically, one can achieve an oriented growth of CDHA crystals onto dissolved collagen fibrils in aqueous solutions via a selforganization mechanism [628]. A number of authors produced calcium orthophosphate/collagen biocomposites by mixing preformed ceramic particles with a collagen suspension [635][636][637]. However, in all blended composites, the crystallite sizes of calcium orthophosphates were not uniform and the crystals were often aggregated and randomly distributed within a fibrous matrix of collagen.…”

Biocomposites and hybrid biomaterials based on calcium orthophosphates

“…747 A number of authors produced calcium orthophosphate/collagen biocomposites by mixing preformed ceramic particles with a collagen suspension. [765][766][767] However, in all blended composites, the crystallite sizes of calcium orthophosphates were not uniform, and the crystals were often aggregated and randomly distributed within a fibrous matrix of collagen. Therefore, no structural similarity to natural bone was obtained, and only a compositional similarity to that of natural bone was achieved.…”

Wear characteristic and biocompatibility of some hydroxyapatite–collagen composite acetabular cups

“…Hydroxyapatite-collagen composites have been prepared by many workers in different forms [8,10,[13][14][15]. In our attempt hydroxyapatite particles were gradually added to deionized water and intensively mixed.…”

“…One of the earliest attempts to develop collagen-calcium phosphate composite was made by Mittlmier and Nizzard [11] who mixed calcium phosphate granules with collagen web. Many other researchers attempted to produce these composites by mixing the preformed calcium phosphate granules in collagen suspension [10][11][12][13][14]. However, very few of these attempts considered the mechanical strength of the composites that suits their realistic uses.…”