“…747 A number of authors produced calcium orthophosphate/collagen biocomposites by mixing preformed ceramic particles with a collagen suspension. [765][766][767] However, in all blended composites, the crystallite sizes of calcium orthophosphates were not uniform, and the crystals were often aggregated and randomly distributed within a fibrous matrix of collagen. Therefore, no structural similarity to natural bone was obtained, and only a compositional similarity to that of natural bone was achieved.…”