Evaluation of a collagen-based biosynthetic material for the repair of abdominal wall defects

Werkmeister, Jerome A.; Edwards, Glenn A.; Casagranda, Franca; White, Jacinta F.; Ramshaw, John A. M.

doi:10.1002/(sici)1097-4636(19980305)39:3<429::aid-jbm12>3.0.co;2-5

Cited by 29 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, it has been shown to perform extremely well as a patch for abdominal wall repair (70). In this study, the material showed excellent durability and healing in rabbits, with clear vascularisation and cell coverage, while no calcification nor abdominal adhesions were observed ( Figure 4A).…”

Section: Fig 2 Immunostaining Of Electroblots Of Dog (D)mentioning

confidence: 63%

See 1 more Smart Citation

Applications of Collagen in Medical Devices

Ramshaw

Vaughan

Werkmeister

2001

Biomed. Eng. Appl. Basis Commun.

Self Cite

View full text Add to dashboard Cite

Collagen is the most abundant natural protein found in living systems. While there is a whole family of different collagen types, each differing in sequence, the properties that make this protein so attractive as the building blocks for medical devices, are reflected largely by the unique fibrillar structure of the molecule, as well as defined functional regions that interact with the surrounding cells and other matrix components. As a commercial medical product, collagen can be part of the natural tissue used in the device, or it can be fabricated as a reconstituted product from animal or recombinant sources. Both types of uses have distinct properties that convey advantages and disadvantages to the end product. This review examines the chemistry and biology of collagen and describes some well-documented examples of collagen-based medical devices produced in one or other of these formats.

show abstract

Section: Fig 2 Immunostaining Of Electroblots Of Dog (D)mentioning

confidence: 63%

“…These data contrast with data for polypropylene mesh, the most commonly used material for this indication, which, in the same animal model system, showed uneven healing and poor vascularisation. There was limited cell coverage, consistent with frequent adhesions (70).…”

Section: Fig 2 Immunostaining Of Electroblots Of Dog (D)mentioning

confidence: 68%

Applications of Collagen in Medical Devices

Ramshaw

Vaughan

Werkmeister

2001

Biomed. Eng. Appl. Basis Commun.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Alternatively, various patches can be made, for example, as vascular repair patches. A further application of a patch is for abdominal repair . Examination in a rabbit model of two samples, one with an open collagen pore structure and one with a closed structure with few pores in the collagen component showed interesting results.…”

Section: Biosynthetic Materialsmentioning

confidence: 99%

Biomedical applications of collagens

Ramshaw

2015

J Biomed Mater Res

Self Cite

View full text Add to dashboard Cite

Collagen-based biomedical materials have developed into important, clinically effective materials used in a range of devices that have gained wide acceptance. These devices come with collagen in various formats, including those based on stabilized natural tissues, those that are based on extracted and purified collagens, and designed composite, biosynthetic materials. Further knowledge on the structure and function of collagens has led to on-going developments and improvements. Among these developments has been the production of recombinant collagen materials that are well defined and are disease free. Most recently, a group of bacterial, non-animal collagens has emerged that may provide an excellent, novel source of collagen for use in biomaterials and other applications. These newer collagens are discussed in detail. They can be modified to direct their function, and they can be fabricated into various formats, including films and sponges, while solutions can also be adapted for use in surface coating technologies.

show abstract

“…However, only a few of them are biocompatible. Natural biodegradable polymers like bovine serum albumin (BSA), human serum albumin (HSA), collagen, gelatin, and hemoglobin have been studied for drug delivery [9,61,62]. Biodegradable polymeric systems can be designed in various shapes such as membranes, pellets, sponges, micro-or nanospheres, depending on the purpose of application.…”

Section: New Materials Based On Blends Of Collagen With Synthetic Polmentioning

confidence: 99%

“…In scientific literature, new words had been designed for the blends of natural polymers with synthetic ones. Materials based on such blends have been called bioartificial or biosynthetic polymeric materials [5][6][7][8][9]. In many scientific articles, one can find that this new vocabulary has been commonly used.…”

mentioning

confidence: 99%

Natural Polymers as Components of Blends for Biomedical Applications

Sionkowska¹

2013

Polymeric Biomaterials

View full text Add to dashboard Cite

INTRODUCTIONThe biomedical sector requests more and more complex structures in attempts to fulfill the requirements of a multitude of different applications. For this reason, polymer scientists exploit existing compounds and also design new compounds with properties that can be considered as new materials for biomedical applications [1,2]. The applications of polymers are essential in surgery, for prosthetic systems, and in pharmacology, for drug formulation and controlled drug delivery. Polymeric biomaterials are usually used under complex, demanding conditions, and must fulfill stringent requirements relating to their chemical, biological, and physicomechanical properties. Therefore, there is an urgent need for new polymeric biomaterials that can satisfy the demanding performance requirements and standards required for these applications [3]. The development of innovative polymeric biomaterials can be an engine of innovation for new medical treatments and therapies. The existing knowledge clearly shows that the careful optimization of the chemical structure of polymers used in medical implants can result in better clinical outcomes for the implant recipients. Biodegradable polymers play a significant role in the preparation of polymeric materials for biomedical applications. They are preferred candidates for developing therapeutic devices such as temporary prostheses, three-dimensional porous structures as scaffolds for tissue engineering, and as controlled/sustained release drug delivery vehicles [4].At the end of the twentieth century, a new trend in the development of polymeric materials was observed [5]. Many scientific laboratories started to work with polymer blends as potential new materials for medicine (biomaterials), the food industry (biodegradable and photodegradable food packaging materials), and for the electronic industry (conducting polymers). Especially, new materials for biomedical applications based on the blends of two polymers were studied. Cell-based transplantation, CONTENTS

show abstract

Evaluation of a collagen-based biosynthetic material for the repair of abdominal wall defects

Cited by 29 publications

References 18 publications

Applications of Collagen in Medical Devices

Applications of Collagen in Medical Devices

Biomedical applications of collagens

Natural Polymers as Components of Blends for Biomedical Applications

Contact Info

Product

Resources

About