Evaluation of a cationic calix[4]arene: Solubilization and self-aggregation ability

A New Approach for Quantitative Determination of γ-Cyclodextrin in Aqueous Solutions: Application in Aggregate Determinations and Solubility in Hydrocortisone/γ-Cyclodextrin Inclusion Complex

“…In case of opalescence solution, it can still be applied where a reversible aggregation process is taking place . Various techniques have been used for cac determinations such as light scattering measurements, nuclear magnetic resonance, vibrational spectroscopy studies, capillary electrophoresis, density and sound velocity measurements, fluorescence spectroscopy, viscosity measurements, osmolality measurements, and surface tension measurements …”

Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents

“…The aminocalix [4]arene was notably better in facilitating the solubilization of lidocaine, paracetamol, ketoprofen and hydrophobic steroids, with 17β-estradiol being the most affected. However, observations suggested that aggregation of the aminocalix[n]arene may be influential and the formation of stoichiometric complexes should not be assumed [67,68].…”

Calixarene-Based Receptors for Molecular Recognition

“…The pH-sensitive amphoteric calix [8]arenes exhibit not only a good hydrophobic drug loading capacity but also pH-triggered drug releasing behavior. Ukhatskaya et al 60 were interested in the evaluation of the solubilizing properties and estimation of the self-aggregation ability of positively charged 5,11,17,23 tetrakis(trimethylammoniomethyl)-25,26,27,28-tetrapropoxy-calix [4]arene tetrachloride (aminocalix) (13), including comparisons with a series of pharmaceutically relevant cyclodextrins. Phase-solubility measurements of some selected drugs (Dexamethasone, hydrocor-tisone, 17 β -estradiol, lidocaine, paracetamol, ketorolac, and ketorpofen) ( Figure 9) with aminocalix and various cyclodextrins (CDs) ( Figure 10) were carried out and aminocalix 13 showed a solubilizing ability that was comparable to the cyclodextrins.…”