Evaluation of a Candida antigen detection test (Cand-TecTM) in the diagnosis of deep candidiasis in neutropenic patients

Evaluation of different commercial ELISA methods for the serodiagnosis of systemic candidosis - Bewertung kommerzieller ELISA-Methoden zur Serodiagnose der systemischen Candidose

“…Results given by antigen detection with the Platelia Ò ELISA for a limited number of sera showed a higher sensitivity than the Candtec Ò test. The sensitivity of the latter was also largely lower than described in our previous study [14] but this discrepancy was not explained. Other authors showed sensitivities and specificities of 40% and 98% and 53% and 94% for mannanemia or antibody detection, respectively [6].…”

Nonvalue of antigen detection immunoassays for diagnosis of candidemia

“…Similar results were obtained for both groups; by using a titer of 1:4, the sensitivity and specificity for candidemia were 64 and 72%, respectively. Several other studies either excluded patients with only candidemia (27) or presented the data without a separate analysis for patients with candidemia (20,25,31). Despite those encouraging results, other investigators have had less favorable experience with the assay.…”

Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants

“…CAND‐TEC was chosen for the serologic diagnosis because only a small sample volume is required and the test results are promptly available. CAND‐TEC has superior sensitivity and a better negative predictive value but poor specificity, and thus it is thought to be useful when determining a treatment strategy …”

“…CAND-TEC has superior sensitivity and a better negative predictive value but poor specificity, and thus it is thought to be useful when determining a treatment strategy. 22,23 To date, there have been no studies on MCFG as a prophylactic antifungal drug in ELBW premature infants. However, in a previous study, FLCZ and MCFG were prophylactically administered to immunocompromised bone-marrow transplant patients, showing that MCFG had better prophylactic effects than FLCZ.…”