2020
DOI: 10.1002/chem.201905776
|View full text |Cite
|
Sign up to set email alerts
|

Evaluation of a Bispidine‐Based Chelator for Gallium‐68 and of the Porphyrin Conjugate as PET/PDT Theranostic Agent

Abstract: In this study a bispidine ligand has been applied to the complexation of gallium(III) and radiolabelled with gallium‐68 for the first time. Despite its 5‐coordinate nature, the resulting complex is stable in serum for over two hours, demonstrating a ligand system well matched to the imaging window of gallium‐68 positron emission tomography (PET). To show the versatility of the bispidine ligand and its potential use in PET, the bifunctional chelator was conjugated to a porphyrin, producing a PET/PDT‐theranostic… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

0
8
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
6
1

Relationship

3
4

Authors

Journals

citations
Cited by 11 publications
(8 citation statements)
references
References 59 publications
0
8
0
Order By: Relevance
“…This scaffold has been previously investigated for the complexation of 64/67 Cu 2+ [12] and 68 Ga 3+ . [13] At hree dimensional representation of the putative structure of the MnL 1 complex is shown in Scheme 2.…”
Section: Introductionmentioning
confidence: 99%
“…This scaffold has been previously investigated for the complexation of 64/67 Cu 2+ [12] and 68 Ga 3+ . [13] At hree dimensional representation of the putative structure of the MnL 1 complex is shown in Scheme 2.…”
Section: Introductionmentioning
confidence: 99%
“…Besides their wellestablished use in the field of catalysis, these unique structures have also captured the attention of the pharmaceutical community over the years. Recently, bispidines have been studied as ligands for radiopharmaceutical applications [15], but also as diagnostic and therapeutic agents for cancer [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…Finally, L 1 can be readily functionalized for biological targeting via the lysine terminal amine. This scaffold has been previously investigated for the complexation of 64/67 Cu 2+[12] and 68 Ga 3+ . A three dimensional representation of the putative structure of the MnL 1 complex is shown in Scheme .…”
Section: Introductionmentioning
confidence: 99%
“…This scaffold has been previously investigated for the complexation of 64/67 Cu 2+ [12] and 68 Ga 3+ . [13] A three dimensional representation of the putative structure of the MnL1 complex is shown in Scheme 2. We evidence here that despite a moderate thermodynamic stability, MnL1 has a resistance to acid catalyzed dissociation and transmetalation which is unprecedented for a Mn 2+ chelate.…”
Section: Introductionmentioning
confidence: 99%