Evaluation of 99mTc-Dimercaptosuccinic Acid Renal Uptake as an Index of
Individual Kidney Function after Acute Ureteral Obstruction and Desobstruction

Schelfhout, W; Simons, M.; Oosterlinck, W; Sy, W. A. De

doi:10.1159/000474087

Cited by 9 publications

(6 citation statements)

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“…In contrast, in studies in both dogs and rats, dynamic 99mTc-DMSA uptake was found to be a good predictor of outcome (McDougal and Flanigan, 1981 ;Schelfout et al, 1983). The fact that the relationship is curvilinear may explain the findings of Chibber et al (1981), where the 99mTc-DMSA DRF tended to underestimate renal recovery.…”

Section: Discussionmentioning

confidence: 98%

Can Renal Blood Flow, Glomerular Filtration Rate or ^99mTc‐DMSA Uptake Predict Outcome in Experimental Unilateral Renal Obstruction?

Kelleher¹,

Anderson²,

Gordon³

et al. 1993

British Journal of Urology

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Single kidney glomerular filtration rate (SK GFR), single kidney blood flow (SK BF) and differential renal function (DRF), using both technetium labelled diethylene-pentaacetic acid (99mTc-DTPA) and dimercaptosuccinic acid (99mTc-DMSA), were examined as predictors of outcome in a pig model of complete unilateral ureteric obstruction. SK GFR and SK BF were unable to predict outcome following relief of obstruction but there was a high curvilinear correlation between DRF assessed at the end of defined periods of obstruction and after relief of obstruction using 99mTc-DMSA. Functional recovery was near complete using DMSA when the loss in DRF did not exceed 30%, after which there was an exponential decline in expected recovery. There was no difference between DRF using 99mTc-DTPA or 99mTc-DMSA in controls or before or after obstruction but significant differences between assessment by these radionuclides existed in the obstructed kidney at 24 h, 5 days, 10 days and 20 days. 99mTc-DMSA is a sensitive agent in the prediction of outcome following acute complete obstruction in the pig but its assessment of DRF in the obstructed kidney differs markedly from that of 99mTc-DTPA.

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Section: Discussionmentioning

confidence: 98%

Can Renal Blood Flow, Glomerular Filtration Rate or ^99mTc‐DMSA Uptake Predict Outcome in Experimental Unilateral Renal Obstruction?

Kelleher¹,

Anderson²,

Gordon³

et al. 1993

British Journal of Urology

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“…Several agents have been used for this purpose, e.g. 99m Tc‐DTPA) [18,20,22], iodine‐orthoiodohippurate ( 131 I‐OIH) [4,23] and 99m Tc‐DMSA [24,25]. The results of various renal scans are conflicting because the different agents are handled differently by the kidney, and thus measure different aspects of renal function.…”

Section: Methods Of Predicting Recoverabilitymentioning

confidence: 99%

“…to obtain a discrete value of GFR or effective renal plasma flow (ERPF). There is an almost general agreement among urologists that if the relative renographic GFR or ERPF has fallen to <10%, then very little recovery of the kidney function can be expected after de‐obstruction, whereas when >10% kidney function can improve considerably [18,20,22–25]. The better the radionuclide uptake, the better the recuperation after de‐obstruction.…”

Section: Methods Of Predicting Recoverabilitymentioning

confidence: 99%

Recoverability of renal function after relief of chronic partial upper urinary tract obstruction

Shokeir

Provoost²,

Nijman

1999

BJU International

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“…Tc-99m labeled DMSA (2,3-dimercaptosuccinicacid) is avidly taken up by cells of the proximal tubule, with about 35% of the injected activity being localized in the renal cortex by one hour [3]. The renal uptake of Tc-99m DMSA parallels the renal function as determined by GFR and accordingly its uptake is significantly decreased in nephropathy [4,5] which is accepted as a poor prognostic sign [6]. Bernheim et al in 1976 proposed renal scintigraphic scanning as a tool to assess the prognosis of ARF using hippuran and concluded that its uptake was a parameter which authorized the prognosis of a favorable course whereas its absence permitted one to envisage an unfavorable course [7].…”

Section: Introductionmentioning

confidence: 99%

Short Term Prognostic Utility of Tc-99m DMSA Renal Imaging in Sepsis Induced Acute Renal Failure; Provisional Data

Amin¹,

Nasr²,

Younis³

et al. 2013

IJCM

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Background: Sound prognostic data in sepsis induced acute renal failure (SARF) are lacking especially on the short term outcome [STO] in the intensive care unit [ICU]. We addressed the use of Tc-99m DMSA [2,3-dimercaptosuccinicacid] renal cortical imaging as a prognostic tool in SARF. This preliminary data could raise Tc-99m DMSA renal imaging as a prognostic tool in SARF that could allow influential interference to prohibit dramatic outcomes as mortality.

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Evaluation of 99mTc-Dimercaptosuccinic Acid Renal Uptake as an Index of Individual Kidney Function after Acute Ureteral Obstruction and Desobstruction

Cited by 9 publications

References 1 publication

Can Renal Blood Flow, Glomerular Filtration Rate or ^99mTc‐DMSA Uptake Predict Outcome in Experimental Unilateral Renal Obstruction?

Can Renal Blood Flow, Glomerular Filtration Rate or ^99mTc‐DMSA Uptake Predict Outcome in Experimental Unilateral Renal Obstruction?

Recoverability of renal function after relief of chronic partial upper urinary tract obstruction

Short Term Prognostic Utility of Tc-99m DMSA Renal Imaging in Sepsis Induced Acute Renal Failure; Provisional Data

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Evaluation of 99mTc-Dimercaptosuccinic Acid Renal Uptake as an Index of Individual Kidney Function after Acute Ureteral Obstruction and Desobstruction

Cited by 9 publications

References 1 publication

Can Renal Blood Flow, Glomerular Filtration Rate or 99mTc‐DMSA Uptake Predict Outcome in Experimental Unilateral Renal Obstruction?

Can Renal Blood Flow, Glomerular Filtration Rate or 99mTc‐DMSA Uptake Predict Outcome in Experimental Unilateral Renal Obstruction?

Recoverability of renal function after relief of chronic partial upper urinary tract obstruction

Short Term Prognostic Utility of Tc-99m DMSA Renal Imaging in Sepsis Induced Acute Renal Failure; Provisional Data

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Product

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Can Renal Blood Flow, Glomerular Filtration Rate or ^99mTc‐DMSA Uptake Predict Outcome in Experimental Unilateral Renal Obstruction?

Can Renal Blood Flow, Glomerular Filtration Rate or ^99mTc‐DMSA Uptake Predict Outcome in Experimental Unilateral Renal Obstruction?