Evaluation of 90-day subchronic oral toxicity of aqueous extract of &lt;i&gt;Gmelina arborea&lt;/i&gt; Roxb (Verbenaceae) leaves in Wistar rats

Osseni, Razack; Azonbakin, Simon; Diallo, Aboudoulatif; Ganfon, Habib; Adjagba, Marius; Kaossarath, Fagbemi; Sekossounon, Sanni; Awede, Bonaventure; Bleich, André; Raphaël, Darboux; Laleye, Anatóle

doi:10.4314/tjpr.v19i3.23

Cited by 4 publications

(3 citation statements)

References 6 publications

(8 reference statements)

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“…Examples of such toxic signs would be characterized by congestion, leukocyte infiltration, degeneration, necrosis, apoptosis and fibrosis in the organ tissues analyzed histologically [71]. Our results are similar to those obtained by Osseni et al [72] who worked on the sub-acute toxicity of aqueous extracts of G. arborea in rats. However, the significant increase in relative weight of liver in female's rats might be due either to the low presence of flavonoids in the roots extract because these secondary metabolites are considered to be hepatoprotective or, could be due to a high sensitivity of the livers to certain bioactives compounds contained in the extract of G. arborea.…”

Section: Discussionsupporting

confidence: 87%

Phytochemical Analysis and Anthelmintic Activity of Ethanolic Extracts of Gmelina arborea on the Bovine Parasite Onchocerca ochengi

Bertrand

Raymond²,

Mathieu³

et al. 2022

JPRI

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Aims: This study was aimed at analyzing the phytochemical constituents, evaluated the in vitro filaricidal activities of the ethanolic extracts of G. arborea on Onchocerca ochengi and carried out the acute and sub-acute toxicity on rats. Place and Duration of Study: The work took place at the Laboratory of Applied Zoology of the Faculty of Science of the University of Ngaoundere between June 2020 and April 2021. Methodology: Quantitative determination of total phenols, total flavonoids and tannins were performed by using standard titration curve of gallic acid and rutin. The adult male worms of O. ochengi were incubated in Roosevelt Park Memorial Institute (RPMI-1640) medium supplemented with antibiotics containing different concentrations of the plant extracts and ivermectin (positive control). The mortality of worms was evaluated using the MTT/formazan colourimetry test after 24 h and 48 h. Acute and sub-acute toxicity tests of G. arborea were evaluated on rats according to OECD 425 and 407 respectively. Results: The quantitative phyto-constituents screening revealed that total phenols (873.33 ± 3.33 mg GAE/g) were the most quantified compound followed by tannins (229.33 ± 0.33 mg GAE/g) and total flavonoids (116 ± 1.01 mg RE/g) in the roots of the plant. 0.22 ± 0.02 mg/mL, 0.17 ± 0.00 mg/mL, 0.16 ± 0.01 and 0.11 ± 0.01 mg/mL were respectively the LC50 of hydroethanolic extracts of the leaves, barks, roots and ivermectin at 48 h. The acute and sub-acute toxicity test showed no toxicity in rats. Conclusion: Looking at the result, the extracts of this plant may be used in novel drug discovery to fight against onchocerciasis.

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Section: Discussionsupporting

confidence: 87%

Phytochemical Analysis and Anthelmintic Activity of Ethanolic Extracts of Gmelina arborea on the Bovine Parasite Onchocerca ochengi

Bertrand

Raymond²,

Mathieu³

et al. 2022

JPRI

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“…The results revealed that the extract had no impact on the behavioral pattern of the rats. Significant changes (p > 0.05) in the relative weights of the kidneys, lungs, heart and spleen were not observed in G. arborea treated rats compared to the untreated healthy control rats [68] .…”

Section: Cytotoxic Propertiesmentioning

confidence: 76%

Ethnomedicinal Uses, Antidiabetic, Antioxidant and Anti-inflammatory Activity of Gmelina arborea Roxb. and Its Bioactive Compounds: A Review

2022

JJC

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Gmelina arborea Roxb. (Family: Verbenaceae) is a medicinal plant that has been used in the treatment of diabetes mellitus (DM) since ancient times. Decoctions prepared from various parts of G. arborea are used in traditional systems of medicine as a remedy against DM and various other diseases. The present review describes the antidiabetic, antioxidant and anti-inflammatory properties of G. arborea extracts and their bioactive phytoconstituents that are likely to contribute to antidiabetic properties and their therapeutic importance in the management of diabetes. A comprehensive literature search was conducted using PubMed, ScienceDirect, Semantic Scholar and Google Scholar databases. Studies published from 1970 to 2021 were considered in this review. Out of the 157 results, 34 articles were excluded being duplications and 58 articles were excluded being outside the scope of this review. The remaining 65 articles were considered in this review. The in vitro and in vivo assays reveal the therapeutic potential of G. arborea in terms of antidiabetic, antioxidant and anti-inflammatory properties, indicating that the plant is a valuable source for developing non-toxic herbal formulations to manage DM.

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Section: Cytotoxic Propertiesmentioning

confidence: 76%

Synthesis and Antimicrobial Activity of Some Piperid-4-one Derivatives against Bacterial Strains

2022

JJC

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A novel compound 2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methyl piperidin-4-one (II) has been synthesized by a previously well-known reaction between (E)-3-(2-ethoxyphenyl)-1-(2-methyloxiran-2-yl)prop-2-en-1-one (I) and ethanol amine. The compound was used to synthesize (Z)-2-((2S,5S)-2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methylpiperidin-4-ylidene)hydrazine-1-carbothioamide (III) through con-den¬sation with thiosemicarbazide in acidic medium. Structures were confirmed by spectral data (IR,1H-NMR and LC-MS). Potential antimicrobial efficiency of the newly synthesized piperidin-4-one derivatives was studied against a Gram-positive bacterial strain (Staphylococcus aureus) and a Gram-negative bacterial strain (Enterobacter sp.) applying the agar dilution method. The results showed that compound (III) has a higher antimicrobial activity than compound (II).

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Evaluation of 90-day subchronic oral toxicity of aqueous extract of <i>Gmelina arborea</i> Roxb (Verbenaceae) leaves in Wistar rats

Cited by 4 publications

References 6 publications

Phytochemical Analysis and Anthelmintic Activity of Ethanolic Extracts of Gmelina arborea on the Bovine Parasite Onchocerca ochengi

Phytochemical Analysis and Anthelmintic Activity of Ethanolic Extracts of Gmelina arborea on the Bovine Parasite Onchocerca ochengi

Ethnomedicinal Uses, Antidiabetic, Antioxidant and Anti-inflammatory Activity of Gmelina arborea Roxb. and Its Bioactive Compounds: A Review

Synthesis and Antimicrobial Activity of Some Piperid-4-one Derivatives against Bacterial Strains

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