Evaluation of 7th Edition of AJCC Staging System for Nasopharyngeal Carcinoma

Ren, Yanling; Qiu, Hai Bo; Yuan, Yujie; Ye, Jinning; Tian, Yunhong; Wen, Bo; Zhang, Weijun; Li, Qun

doi:10.7150/jca.19197

Cited by 20 publications

(14 citation statements)

References 23 publications

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“…20 Fourth, imaging examination in the IMRT era is superior to that of the past, an improvement which facilitates better treatment. We also observed that T and N stage and age were independent predictors for OS in the multivariate Cox proportional hazards model analysis, which was consistent with previous studies [21][22][23] and which demonstrated the rationality of the staging system based on imaging guidance in the IMRT age. The present study showed that LRFS was correlated with T stage, and the LRFS of T1-2 cases was significantly higher than that of T3-4 cases in the multivariate analysis (HR=4.51, 95% CI: 1.33-15.1, P=0.017).…”

Section: Discussionsupporting

confidence: 91%

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Long-Term Survival After Nasopharyngeal Carcinoma Treatment in a Local Prefecture-Level Hospital in Southern China

Zhang

Feng

et al. 2020

CMAR

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Purpose: NPC is a malignant and invasive tumor with the incidence rate of 19/100,000per year in Zhongshan City, a prefecture city in southern China. Long-term survival analysis on intensity-modulated radiotherapy (IMRT)-based treatment in local prefecture-level hospitals have not been investigated. We aimed to evaluate the 5-year clinical outcomes and prognostic factors of NPC treated with IMRT in Zhongshan City People's Hospital (ZSPH), a prefecture-level hospital in South China. Patients and Methods: The number of 149 newly diagnosed non-metastatic NPC cases treated with IMRT were included from Zhongshan City People's Hospital between January 2010 and December 2011. The survival outcomes, treatment toxicities and prognostic factors were analyzed by Kaplan-Meier method and Cox proportional hazards model. Results: With a median follow-up period of 65 months for the cohort, the 5-year local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS) and distant metastasis-free survival (DMFS) and overall survival (OS) were 86.80%, 94.80%, 86.10% and 80.50%, respectively. The 5-year OS rates were 100%, 95.2%, 87% and 67.2% for stage I, II, II and IVa-b, respectively (P=0.004). The 5-year LRFS rates were 97.2%, 96.0%, 90.4% and 72.0% for T1, T2, T3 and T4, respectively (P=0.001); the 5-year DMFS rates were 100% for T1, 96.8% for T2, 81.9% for T3 and 74.6% for T4 (P=0.022). A multivariate analysis revealed tumor stage as an independent prognostic factor for LRFS, DMFS and OS. No patients died from acute toxicities. Late toxicities were observed for 130 (87.2%) patients, and most late toxicities were graded I/II. Conclusion: NPC treatment effect in a prefecture-level hospital in South China was comparable to international results and toxicities were tolerable. Tumour stage was an independent prognostic factor for survival outcome. More NPC survival data from local and remote places are needed.

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Section: Discussionsupporting

confidence: 91%

“…That finding was consistent with the latest research. 21,22,30 In general, acute and chronic toxicities were tolerable. Acute injuries grade 3 and above accounted for less than 30% of all toxicities, and those injuries improved after symptomatic treatment.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Survival After Nasopharyngeal Carcinoma Treatment in a Local Prefecture-Level Hospital in Southern China

Zhang

Feng

et al. 2020

CMAR

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“…The clinicopathological information of these patients is listed in Table I . The clinical stage was defined based on the International Union Against Cancer ( 24 ). All patients provided written informed consent for the use of clinical materials, and the current study was approved by the Institutional Ethics Committee at Jiangsu Taizhou People's Hospital.…”

Section: Methodsmentioning

confidence: 99%

MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52

Zhao

Chu

2018

Exp Ther Med

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MicroRNAs (miRs) have been demonstrated to be important regulators of malignant behavior in nasopharyngeal carcinoma (NPC) tumorigenesis. The present study aimed to investigate the biological roles and underlying mechanisms of miR-379 in NPC. The study initially observed that miR-379 was significantly downregulated in NPC clinical tissues and cell lines using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Next, gain-of-function assays were performed on human the NPC cell lines, C666-1 and 5-8F, including MTT, colony formation and transwell migration assays. The results indicated that ectopic expression of miR-379 suppressed the NPC cell proliferation, colony formation, migration and invasion in vitro. In addition, tumor protein D52 (TPD52) was identified as a direct target of miR-379 by a dual-luciferase reporter assay, while overexpression of miR-379 markedly reduced TPD52 expression at the mRNA and protein levels, as determined by RT-qPCR and western blot analysis, respectively. Furthermore, silencing of TPD52 significantly inhibited the C666-1 cell proliferation, migration and invasion. These findings suggest that miR-379 negatively regulates the growth and migration of NPC cells by downregulating TPD52 expression, while modulation of miR-379 expression may be a therapeutic strategy for NPC.

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“…Currently, the prognosis of patients with NPC is primarily based on the Tumor-Node-Metastasis (TNM) staging system. However, extreme variation in clinical outcomes has been reported among patients with the same TNM stage who received similar treatment regimens 4. This phenomenon suggests that the present staging system alone is far from a perfect predictive tool for prognosis and treatment efficacy.…”

Section: Introductionmentioning

confidence: 98%

Pretreatment Aspartate Aminotransferase-to-Alanine Aminotransferase (De Ritis) Ratio Predicts the Prognosis of Nonmetastatic Nasopharyngeal Carcinoma

Zhou¹,

Li²,

Wang³

et al. 2019

OTT

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These authors contributed equally to this work Background: The pretreatment aspartate aminotransferase-to-alanine aminotransferase (De Ritis) ratio is reportedly valuable in prognosis prediction of various malignancies. However, its value in the prognosis of nasopharyngeal carcinoma (NPC) has not yet been reported. This study aimed to evaluate the effect of the De Ritis ratio on the survival outcomes of patients with nonmetastatic NPC. Methods: We retrospectively reviewed the medical data of 1023 patients with nonmetastatic NPC admitted between 2009 and 2013 at a single center. The Fine and Gray competing risk regression model was used to analyze the associations between the De Ritis ratio and the survival outcomes of cancer-specific survival (CSS) and progression-free survival (PFS) by using the subdistribution hazard ratio (SHR) and 95% confidence interval (CI) as size effects. The Cox proportional hazard model was used to evaluate the correlation between the De Ritis ratio and overall survival (OS) by using hazard ratio (HR) and 95% CI as size effects. Results: Patients were divided into two groups in accordance with the pretreatment De Ritis ratio by using an optimal cutoff value of 1.65. Compared with the patients with low De Ritis ratio (< 1.65), those with elevated De Ritis ratio (≥ 1.65) had poorer prognosis with regard to CSS, PFS, and OS. Notably, multivariate analyses showed that high De Ritis ratio was independently associated with poor CSS (SHR = 1.64, 95% CI: 1.25-2.16), PFS (SHR = 1.69, 95% CI: 1.30-2.19), and OS (HR = 1.81, 95% CI: 1.39-2.40). Conclusion: Pretreatment De Ritis ratio can be an independent prognostic predictor for patients with nonmetastatic NPC.

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Evaluation of 7th Edition of AJCC Staging System for Nasopharyngeal Carcinoma

Cited by 20 publications

References 23 publications

<p>Long-Term Survival After Nasopharyngeal Carcinoma Treatment in a Local Prefecture-Level Hospital in Southern China</p>

<p>Long-Term Survival After Nasopharyngeal Carcinoma Treatment in a Local Prefecture-Level Hospital in Southern China</p>

MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52

<p>Pretreatment Aspartate Aminotransferase-to-Alanine Aminotransferase (De Ritis) Ratio Predicts the Prognosis of Nonmetastatic Nasopharyngeal Carcinoma</p>

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