Evaluation of 5-fluorouracil in the treatment of actinic keratosis of the lip

Evaluation of the Effectiveness of Imiquimod and 5-Fluorouracil for the Treatment of Actinic Keratosis: Critical Review and Meta-analysis of Efficacy Studies

“…9,13,15,[23][24][25][26][27][28][29] Seventeen studies were excluded since they did not meet the inclusion criteria for various reasons (Table I). [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] Meta-analysis of 5-Fluorouracil The efficacy rates found for treating actinic keratoses of the face and/or anterior bald scalp with topical fluorouracil are summarized in Table II. 9,13,15,[23][24][25]27 The primary efficacy variable was the complete (100%) clearance rate.…”

“…Abadir 30 5-FU Combination of cryotherapy with 5-FU Robinson and Kligman 43 5-FU Combination of treatments on extremities Bercovitch, 31 Kurwa et al 36 5-FU Treatment of arms and/or hands only Persaud et al 41 Imiquimod Treatment of AKs on body; lesional reduction Bianchi et al, 32 Eklind et al, 34 Persaud and Lebwohl 40 Imiquimod Case reports Epstein, 35 Warnock et al 46 5-FU Treatment of actinic cheilitis only Labanderia et al, 37 Smith et al, 45 Loven et al 38 5-FU Lesional reduction results reported Pearlman, 39 Robins 42 5-FU Pulse dosing therapy Salasche et al, 44 Chen et al 33 Imiquimod Cycle therapy A. K. Gupta et al Imiquimod and 5-FU for AK regimen and was used continuously for no longer than 16 weeks, as per the labeling. In their initial case study, 28 complete clearance of lesions was reported in each of the six patients (100%).…”

Topical Antineoplastic Agents in the Treatment of Mucocutaneous Diseases

“…While clinical improvement was appreciated after 5-FU therapy in another study, the investigators subsequently found that posttreatment histology showed residual dysplasia in all patients [14]. A randomized clinical trial comparing topical 5-FU 5% solution applied 3 times daily for 2 weeks to surgical vermilionectomy, trichloracetic acid peel and carbon dioxide (CO 2 ) laser ablation of the vermilion border found significantly more recurrences in the topically treated groups than in the surgical or laser groups [15].…”

Solar cheilosis: An ominous precursor

“…74 The use of a 1% solution, followed by a posttreatment biopsy specimen for histologic confirmation, revealed persistent residual dysplasia despite clinical resolution of the condition in all patients. 73 Some have suggested using 5-FU ''pulse therapy,'' which consists of larger doses applied at one time and repeated after a brief period of omission of treatment. 75,76 There was no significant difference in the rate of histologic resolution of SC between pulse therapy and the standard applications of 5-FU.…”