Evaluation of 48 Cases of Orbital Exenteration

Rathbun, J. Earl; Beard, Crowell; Quickert, Marvin H.

doi:10.1016/0002-9394(71)91613-8

Cited by 73 publications

(47 citation statements)

References 4 publications

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“…6,[13][14] In our study local recurrence rate was 18.7% and recurrences were observed within a median of 2.3 years. We suggest that the first three years are the most important period for follow-up of local recurrences.…”

Section: Discussionsupporting

confidence: 52%

Orbital Exenterations: Our experience at Ankara Oncology Research And Training Hospital.

Duman¹

2013

UHOD

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The aim of this study is to review our 5 year experience with orbital exenterations and to evaluate the demographic and clinical features of patients, indications and outcomes. Between January 2008 and December 2012, 16 patients who underwent orbital exenteration were included in the study. Most of the lesions originated from eyelid (n= 14) and remaining 2 lesions originated from orbit. Histopathological examination of the lesions were consistent with basal cell carcinoma (n= 7), squamous cell carcinoma (n=5), sebaceous carcinoma (n= 2), choroidal melanoma (n= 1) and adenoid cystic carcinoma (n= 1). Secondary orbital tumours are the major indication for orbital exenteration. Aggressive removal of primary tumours can reduce the frequency of this disfiguring procedure.Keywords: Orbital exenteration, Orbital tumour, Squamous cell carcinoma, Basal cell carcinoma, Eyelid sebaceous carcinoma ÖZET Orbital Ekzenterasyonlar: Ankara Onkoloji Araflt›rma ve E¤itim Hastanesindeki DeneyimlerimizBu çal›flman›n amac› orbital ekzenterasyonlarla ilgili befl y›ll›k deneyimlerimlerimizi gözden geçirmek, hastalar›n demografik ve klinik özelliklerini, endikasyonlar›n› ve sonuçlar›n› de¤erlendirmektir. Ocak 2008 ile Aral›k 2012 aras›nda, orbital ekzenterasyon yap›lan 16 hasta çal›flmaya al›nd›. Lezyonlar›n ço¤u göz kapa¤›ndan kaynaklanmakta, geriye kalan 2 lezyon ise orbitadan (% 12.5) kaynaklanmakta idi. Lezyonlar›n histopatolojik incelemesi bazal hücreli karsinom (n= 7), skuamöz hücreli karsinom (n= 5), sebase karsinom (n= 25), koroidal melanom (n= 1) ve adenoid kistik karsinom (n= 1) ile uyumlu idi. Ekzenterasyonlar›n en önemli endikasyonu sekonder orbita tümörleri idi. Primer tümörlerin agresif tedavisi kötü görünüme sebep olan bu prosedür s›kl›¤›n› azaltabilir.Anahtar Kelimeler: Orbital ekzenterasyon, Orbital tümör, Yass› hücreli karsinom, Bazal hücreli karsinom, Göz kapa¤›n›n sebase bez karsinomu ULUSLARARASı HEMATOLOJI-ONKOLOJI DERGISI ARTICLE

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Section: Discussionsupporting

confidence: 52%

Orbital Exenterations: Our experience at Ankara Oncology Research And Training Hospital.

Duman¹

2013

UHOD

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“…1,4,6,7 The remainder originate almost exclusively in the conjunctiva, orbit, or globe. Tumours arising in the paranasal sinuses and nose may also require exenteration to achieve local control, but these tumours usually do not present to an ophthalmologist.…”

Section: Indicationsmentioning

confidence: 99%

Orbital exenteration for invasive skin tumours

Tyers

2006

Eye

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Orbital exenteration aims at local control of disease invading the orbit that is potentially fatal or relentlessly progressive. Of all exenterations presenting to ophthalmologists, 40-50% are required for tumours in the eyelid or periocular skin. 99% of these are basal cell carcinomas and 4-6% each are squamous cell carcinomas or sebaceous gland carcinomas. Orbital invasion results in progressive fixation of the tumour to bone and reduced ocular motility. Perineural invasion of branches of the trigeminal nerve leads to numbness or pain, and that the facial nerve, to weakness. Biopsy identifies the cell type and the presence of perineural invasion. CT and MRI scanning help in the assessment of tumour spread within the orbit. Management should be in collaboration with an oncologist. Exenteration may be totalthe removal of all orbital contents-or lidsparing if the tumour is placed posteriorly. The socket may be allowed to heal by granulation or lined with a split skin graft or local flap. Complications may be seen following 20-25% of exenterations and include fistulae, tissue necrosis, exposed bone, and infection. Incomplete clearance of tumours occurs in about 38% of total exenterations and 17% of subtotal. The overall 5-year survival is 55-65%, but significantly worse if there was perineural spread. Facial prostheses may be mounted on glasses or secured with tissue glue or osseointegrated implants. Excellent cosmetic results can be achieved but many patients prefer to wear a patch.

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“…Levin & Dutton, em 1991, descreveram uma série de 99 pacientes submetidos à exenteração, mostrando também o CEC e o CBC como principais etiologias (2) . No entanto, outros trabalhos mostraram o carcinoma basocelular como a causa mais freqüente de exenteração orbital (1,3) seguido do carcinoma espinocelular em um estudo (1) ou do melanoma maligno e dos tumores de glândula lacrimal em outro (3) . No período pós-operatório, três pacientes sofreram necrose de enxerto, um apresentou fístula de seio etmoidal para a órbita e outro apresentou diminuição de fórnice inferior.…”

Section: Discussionunclassified

“…As principais indicações para realização de exenteração são as neoplasias malignas primárias de pálpebra e as de conjuntiva, com invasão orbital (principalmente o carcinoma basocelular e o espinocelular) (1)(2)(3) . Em geral, estas lesões são facilmente diagnosticadas e podem ser curadas se tratadas adequadamente no início da doença (4) .…”

Section: Introductionunclassified