Evaluation of (4-aminobutyloxy)quinolines as a novel class of antifungal agents

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

“…Fungi, ubiquitously found in the milieu [192], are responsible for the fungal infections/diseases, which can be either superficial or systemic [193,194]. In order to combat these infections, a number of antifungal agents are clinically available [195].…”

Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2

“…Quinolines are heterocyclic molecules composed of fused benzene and pyridine rings. The quinolines and their derivatives have shown a wide range of biological activities, including antiproliferative [8], antiviral [9], antibacterial [10], antifungal [11], anti-inflammatory [12], and antiparasitic [13]. Members of the quinoline family, such as chloroquine and hydroxychloroquine, have shown antiviral activity against several viruses, such as coronaviruses [9], human immunodeficiency virus [14], and respiratory syncytial virus [15].…”

Synergistic Diastereo‐ and Enantioselective Functionalization of Unactivated Alkyl Quinolines with α,β‐Unsaturated Aldehydes

“…[6] When the reaction was performed on 2-ethyl quinoline,t he final product 4p was obtained in modest yield and excellent diastereo-and enantioselectivity.T hese results showed that the reaction is very robust, tolerates any type of substituent in different positions on the quinoline ring, and is not limited to only methyl substituted quinolines,b ut also worked with al onger alkyl chain, generating aq uaternary stereocenter. We were pleased to find that the reaction proceeds with electron-donating groups in the 6-position of the quinoline moiety,m aintaining the excellent selectivities,a lthough lower yields of 4h,i were obtained.…”

“…One concept is based on deprotonation of the alkyl chain by as toichiometric amount of as trong base. [6] Recently,C (sp 3 ) À Hf unctionalization reactions of various 2alkyl quinolines have been reported. [5] Theq uinoline scaffold is particularly important as it can be found in al arge variety of bioactive compounds.…”

“…[5] Theq uinoline scaffold is particularly important as it can be found in al arge variety of bioactive compounds. [6] Recently,C (sp 3 ) À Hf unctionalization reactions of various 2alkyl quinolines have been reported. These studies include the addition of 2-methyl quinolines to enones and methylenemalononitrile,i nw hich the substrate is activated by ytterbium or scandium, respectively.…”