Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties

Jansen, Olivia; Angenot, Luc; Tits, Monique; Nicolas, Jean‐Pierre; Mol, Patrick De; Nikiema, Jean‐Baptiste; Frédérich, Michel

doi:10.1016/j.jep.2010.04.032

Cited by 74 publications

(50 citation statements)

References 39 publications

(43 reference statements)

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“…Ethyl acetate and dichloromethane crude extracts and hydroxy-γ-isosanshool (purity 90.58 %) were tested in vitro against the Plasmodium falciparum 3D7 strain. In line with WHO guidelines and previous results from our team (Jansen et al [10], Jonville et al [11]), antiplasmodial crude extract activity was classified as follows: IC 50 ≤ 15 µg/mL, promising activity; IC 50 = 15-50 µg/mL, moderate activity; IC 50 > 50 µg/mL, weak activity; and at a level that cannot explain the existence of antiplasmodial activity in the plant: IC 50 > 100 µg/mL, inactivity. The dichloromethane crude extract showed weak activity (77.8 ± 7.3 µg/mL), the ethyl acetate extract showed moderate activity (38.0 ± 11.3 µg/mL), and hydroxy-γ-isosanshool showed moderate activity for a pure compound (11.3 ± 1.5 µg/mL).…”

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confidence: 88%

“…The P. falciparum culture was placed in contact with a set of eight twofold dilutions of each extract in medium (final concentrations ranging from 0.8 to 100 µg/mL and final DMSO concentration ≤ 1 %) on two columns of a 96-well microplate for 48 h, as described by Jansen and al. [10]. Parasite growth was estimated by the determination of plasmodial lactate dehydrogenase activity as previously described [13].…”

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confidence: 99%

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Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria

Ledoux¹,

Maraetefau²,

Jansen³

et al. 2015

Planta Med Lett

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!The aim of this study was to evaluate the antiplasmodial properties of Zanthoxylum heterophyllum, an endemic plant from the Mascarene Islands. In vitro antiplasmodial activity of ethyl acetate and dichloromethane crude extracts obtained from leaf samples collected on Reunion Island was evaluated on the Plasmodium falciparum 3D7 chloroquine-sensitive strain using a colorimetric method. The major active compound was identified by chromatographic and spectroscopic methods. The best antiplasmodial activity was obtained for the ethyl acetate extract (15 µg/ mL < IC 50 < 50 µg/mL). The major compound was identified as a sanshool derivative, an alkylamide compound that has moderate antimalarial activity (IC 50 = 11.3 µg/mL). This is the first report of the presence of a sanshool derivative in Z. heterophyllum. The moderate antiplasmodial activity of hydroxy-γ-isosanshool was demonstrated for the first time. Key wordsZanthoxylum heterophyllum · Rutaceae · malaria · antiplasmodial activitiy · Réunion Island · sanshool Supporting information available online at http://www.thieme-connect.de/products According to the last World Malaria Report [1], there were an estimated 627 000 malaria deaths worldwide in 2012. Malaria is caused by a parasite Plasmodium sp. and transmitted by Anopheles mosquitoes. The problem of parasite resistance towards available medicines such as chloroquine is increasing. Natural products could play an important role in the discovery of new antimalarial drugs. Indeed, the vegetal kingdom is an important source of new pharmacological active compounds, especially for the search of new antimalarial drugs as reviewed by Bero and al. [2]. Zanthoxylum heterophyllum Sm. is an endemic plant from Reunion Island, which belongs to the Rutaceae family [3]. In the traditional pharmacopoeia of the island, Z. heterophyllum, commonly named "poivrier des hauts", is used for the treatment of backaches [4]. As far as we know, pharmacological properties of this plant have not been studied before, except in a paper where methanol leaf and stem extracts showed free radical scavenging properties [5]. Nevertheless, some Zanthoxylum species are known to have antiplasmodial properties, such as Zanthoxylum chalybeum [6] and Zanthoxylum zanthoxyloides [7]. Results and Discussion !The major compound present in the ethyl acetate crude extract was identified as a sanshool derivative. Some sanshool derivates were already described in Zanthoxylum sp., such as Z.anthoxylum piperitum [8] and Z.anthoxylum integrifoliolum [9]. By comparison of our NMR and MS data with literature data, it was identified as hydroxy-γ-isosanshool (l " Fig. 1), described by Chen et al. [9]. Ethyl acetate and dichloromethane crude extracts and hydroxy-γ-isosanshool (purity 90.58 %) were tested in vitro against the Plasmodium falciparum 3D7 strain. In line with WHO guidelines and previous results from our team (Jansen et al. [10], Jonville et al. [11]), antiplasmodial crude extract activity was classified as follows: IC 50 ≤ 15 µg/mL, promising activ...

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confidence: 88%

mentioning

confidence: 99%

Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria

Ledoux¹,

Maraetefau²,

Jansen³

et al. 2015

Planta Med Lett

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“…The B. dalzielii leaves (Jansen et al 2010) have been extracted via dichloromethane, methanol or decoction (water). The yields were 4.7%, 24.7% and 33.4%, respectively.…”

Section: Yield and Chemical Compositionmentioning

confidence: 99%

Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves

Kohoude

Gbaguidi

Agbani

et al. 2016

Pharmaceutical Biology

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Context: Boswellia dalzielii Hutch. (Burseraceae) is an aromatic plant. The leaves are used for beverage flavouring.Objective: This study investigates the chemical composition and biological activities of various extracts. Materials and methods: The essential oil was prepared via hydrodistillation. Identification and quantification were realized via GC-MS and GC-FID. Consecutive extractions (cyclohexane, dichloromethane, ethyl acetate and methanol) were carried out and various chemical groups (phenolics, flavonoids, tannins, antocyanins and sugar) were quantified. The volatile compounds of organic extracts were identified before and after derivatization. Antioxidant, antihyperuricemia, anti-Alzheimer, anti-inflammatory and anticancer activities were evaluated. Results: In the essential oil, 50 compounds were identified, including 3-carene (27.72%) and a-pinene (15.18%). 2,5-Dihydroxy acetophenone and b-D-xylopyranose were identified in the methanol extract. Higher phenolic (315.97 g GAE/kg dry mass) and flavonoid (37.19 g QE/kg dry mass) contents were observed in the methanol extract. The methanol extract has presented remarkable IC 50 ¼ 6.10 mg/L for antiDPPH, 35.10 mg/L for antixanthine oxidase and 28.01 mg/L for anti-5-lipoxygenase. For acetylcholinesterase inhibition, the best IC 50 (76.20 and 67.10 mg/L) were observed, respectively, with an ethyl acetate extract and the essential oil. At 50 mg/L, the dichloromethane extract inhibited OVCAR-3 cell lines by 65.10%, while cyclohexane extract inhibited IGROV-1 cell lines by 92.60%. Discussion and conclusion: Biological activities were fully correlated with the chemical groups of the extracts. The ethyl acetate and methanol extracts could be considered as potential alternatives for use in dietary supplements for the prevention or treatment of diseases because of these extracts natural antioxidant, antihyperuricemic and anti-inflammatory activities.ARTICLE HISTORY

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“…A study carried out to evaluate the antiplasmodial activity of F. thonningii against Plasmodium falciparum the protozoan parasite that causes malaria reported no significant antiplasmodial activity (Jansen et al, 2010). F. thonningii possibly just possesses good insect repellent properties and hence reduces the contact of the vector with humans, minimising incidence of malaria transmission (Jansen et al, 2010;Innocent, 2008). Amongst the compounds isolated in F. thonningii essential oils is the C-15 compound; 6, 10, 14 trimethyl-2-pentadecanone an aliphatic methyl ketone which has been reported to possess insect repellent properties.…”

Section: Antiprotozoal Propertiesmentioning

confidence: 99%

Phytochemistry, pharmacology and ethnomedicinal uses of Ficus thonningii (Blume moraceae): A review

Dangarembizi¹,

Erlwanger²,

Moyo³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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The common wild fig, Ficus thonningii, is extensively used in African ethnomedicine for treating a number of disease conditions which include diarrhoea, urinary tract infections, diabetes mellitus, gonorrhoea, respiratory infections, and mental illnesses. This review aims to present a logical analysis of the nutritional, phytochemical and pharmacological properties of F. thonningii in relation to its therapeutic applications. A bibliographic analysis of the uses, phytochemical constituents and phytophamacological properties of Ficus thonningii was carried out using published papers, medicinal plant databases and various ethnobotanical and ethnopharmacological books. Ficus thonningii contains various bioactive compounds which include alkaloids, terpenoids, flavonoids, tannins and active proteins, all of which contribute to its curative properties. In vitro and in vivo pharmacological studies revealed that F. thonningii possesses antimicrobial, antidiarrhoeal, antihelmintic, antioxidant, anti-inflammatory and analgesic properties. Acute and sub-chronic toxicity studies have shown that Ficus thonningii is non-toxic if administered orally in low doses. Scientific research has validated the ethnomedicinal claims that Ficus thonningii is useful in disease management. However, there is need to continue identifying, isolating and quantifying the active principles and possibly determine the mechanisms underlying its curative properties.

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Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties

Cited by 74 publications

References 39 publications

Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria

Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria

Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves

Phytochemistry, pharmacology and ethnomedicinal uses of Ficus thonningii (Blume moraceae): A review

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